Výsledky vyhledávání - "A. Brent Fruin"

Colonic Metaplasia in the Ileal Pouch Is Associated With Inflammation and Is Not the Result of Long-Term Adaptation

Autor: Michael J. O'Brien, Ola El-Zammer, Arthur F. Stucchi, A. Brent Fruin, James M. Becker

Publikováno v: Journal of Gastrointestinal Surgery. 7:246-254

Ileal pouch-anal anastomosis (IPAA) is the preferred surgical therapy for chronic ulcerative colitis (CUC) and familial adenomatous polyposis (FAP). Previous studies have demonstrated morphologic changes in pouch mucosa such as villous atrophy and cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80e58233f4ef0df900904bd11733db4
https://doi.org/10.1016/s1091-255x(02)00191-9

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Neurokinin-1 Receptor and Substance P Messenger RNA Levels Increase during Intraabdominal Adhesion Formation

Autor: Karen L. Reed, Michael Nicolaou, A. Brent Fruin, James M. Becker, Arthur F. Stucchi, Kelly K. Bishop-Bartolomei, Adam C. Gower, Susan E. Leeman

Publikováno v: Journal of Surgical Research. 108:165-172

Background. Intraabdominal peritoneal adhesions are a significant cause of postoperative morbidity and remain one of the major long-term complications associated with abdominal surgery. Adhesion formation at the molecular level involves a complex int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e69e08cc06dc4aed9f559892887822b
https://doi.org/10.1006/jsre.2002.6533

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Is profound peripheral insulin resistance in patients with pancreatic cancer caused by a tumor-associated factor?

Autor: Per Jacobsson, Jörgen Larsson, A. Brent Fruin, Johan Permert, Thomas E. Adrian, Lennart Jorfelt

Publikováno v: The American Journal of Surgery. 165:61-67

Diabetes in patients with pancreatic cancer occurs in 70% to 80% of the patients and is characterized by high plasma levels of insulin. In type II diabetes that is not associated with pancreatic cancer, peripheral insulin resistance and impaired musc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a535f1fc7714ef663f9e56e5c5ece6
https://doi.org/10.1016/s0002-9610(05)80405-2

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Adhesion Formation

Autor: A. Brent Fruin, Arthur F. Stucchi, Ali M. Ghellai, James M. Becker

Publikováno v: The Sages Manual ISBN: 9780387236865

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a010b98a253c46f8156c6ed25753e9b6
https://doi.org/10.1007/0-387-29050-8_58

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A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity

Autor: Adam C. Gower, A. Brent Fruin, Susan E. Leeman, James M. Becker, Arthur F. Stucchi, Karen L. Reed

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 101(24)

Fibrous adhesions remain a major sequela of abdominal surgery. The proinflammatory peptide substance P (SP), known to participate in inflammatory events, may play a key role in adhesion formation. This hypothesis was tested by using an antagonist, CJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa624d2ef4c19a3da8dd67facbc9b01a
https://pubmed.ncbi.nlm.nih.gov/15187234

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NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats

Autor: Michael J. O'Brien, Chris Andry, A. Brent Fruin, Karen L. Reed, Kelly D. Gonzales, James M. Becker, Arthur F. Stucchi, Adam C. Gower

Publikováno v: Digestive diseases and sciences. 50(12)

Nuclear factor kappa B (NF-kappa B) plays a key role in initiating inflammation associated with colitis. A systematic study was conducted in the rat DSS colitis model to determine the temporal relationship between NF-kappa B activation and expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c37f1c86c9945d474b900ee7a0526b
https://pubmed.ncbi.nlm.nih.gov/16416193

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A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus

Autor: James P. McClung, Khaled O. Shebani, Charalabos Pothoulakis, Michael J. O'Brien, Chi-Chung Wang, Susan E. Leeman, A. Brent Fruin, James M. Becker, Karen L. Reed, Arthur F. Stucchi, Chris Andry, Adam C. Gower

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology. 285(6)

Ileal pouch-anal anastomosis (IPAA) is an excellent surgical option for patients with chronic ulcerative colitis (CUC) requiring colectomy; however, persistent episodes of ileal pouch inflammation, or pouchitis, may result in debilitating postoperati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463a2758e7263a91b017832ffdefcad7
https://pubmed.ncbi.nlm.nih.gov/12893626

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Pouchitis in a rat model of ileal J pouch-anal anastomosis

Autor: James P. McClung, Wayne W. LaMorte, Khaled O. Shebani, Denise W. Gee, Eve R. Beer, Arthur F. Stucchi, James M. Becker, Brent Fruin

Publikováno v: Inflammatory bowel diseases. 8(1)

Endorectal ileal pouch-anal anastomosis (IPAA) has become the operation of choice for patients with chronic ulcerative colitis. Although this procedure improves the quality of life, pouchitis remains a significant postoperative complication. Because

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e585c9c83518750af084b974c1c20d
https://pubmed.ncbi.nlm.nih.gov/11837935

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