Zobrazeno 1 - 10
of 124
pro vyhledávání: '"A. Brent Carter"'
Autor:
Jennifer L. Larson-Casey, Shanrun Liu, Jennifer M. Pyles, Suzanne E. Lapi, Komal Saleem, Veena B. Antony, Manuel Lora Gonzalez, David K. Crossman, A. Brent Carter
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Emerging data indicate an association between environmental heavy metal exposure and lung disease, including lower respiratory tract infections (LRTIs). Here, we show by single-cell RNA sequencing an increase in Pparg gene expression in lung macropha
Externí odkaz:
https://doaj.org/article/947822a27e1045b1b6d20a914f2e5074
Autor:
Ting Guo, Chun-sun Jiang, Shan-Zhong Yang, Yi Zhu, Chao He, A. Brent Carter, Veena B. Antony, Hong Peng, Yong Zhou
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Pulmonary fibrosis is characterized by stiffening of the extracellular matrix. Fibroblasts migrate in the direction of greater stiffness, a phenomenon termed durotaxis. The mechanically guided fibroblast migration could be a crucial step in the progr
Externí odkaz:
https://doaj.org/article/5a3f5625d2c446e6a2026f0f24b70bbc
Autor:
Linlin Gu, Jennifer L. Larson Casey, Shaida A. Andrabi, Jun Hee Lee, Selene Meza-Perez, Troy D. Randall, A. Brent Carter
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with an increased mortality. Metabolic reprogramming has a critical role in multiple chronic diseases. Lung macrophages expressing the mitochondrial calcium uniporter (MCU) have a critical
Externí odkaz:
https://doaj.org/article/cc69f67a1ef343f9a517eb1deabc04ba
Autor:
Stephanie B. Wall, Rui Li, Brittany Butler, Ashley R. Burg, Hubert M. Tse, Jennifer L. Larson-Casey, A. Brent Carter, Clyde J. Wright, Lynette K. Rogers, Trent E. Tipple
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 632 (2021)
Background: Alveolar macrophages (AMs) are resident inflammatory cells in the lung that serve as early sentinels of infection or injury. We have identified thioredoxin reductase 1 inhibition by gold compounds increases activation of nuclear factor er
Externí odkaz:
https://doaj.org/article/29d7bf6060744e24a2b5c48a3154c5d8
Autor:
Jennifer Larson-Casey, A. Brent Carter
Publikováno v:
Bio-Protocol, Vol 6, Iss 22 (2016)
The production of reactive oxygen species, including H2O2, is a process that can be used in signaling, cell death, or immune response. To quantify oxidative stress in cells, a fluorescence technique has been modified from a previously described metho
Externí odkaz:
https://doaj.org/article/5164e870a6e448368769498f58264b8c
Autor:
Jennifer Larson-Casey, A. Brent Carter
Publikováno v:
Bio-Protocol, Vol 6, Iss 22 (2016)
Because transforming growth factor-β (TGF-β1) induces differentiation of fibroblasts to myofibroblasts, we developed a protocol to evaluate alveolar macrophage-derived TGF-β1 regulation of lung fibroblast differentiation (Larson-Casey et al., 2016
Externí odkaz:
https://doaj.org/article/7d0fa7fa951e4649aa981784377df699
Autor:
Jyotsana Pandey, Jennifer L. Larson-Casey, Mallikarjun H. Patil, Rutwij Joshi, Chun-sun Jiang, Yong Zhou, Chao He, A. Brent Carter
Publikováno v:
Journal of Biological Chemistry. 299:104695
Autor:
Rui-Han Hu, Mustapha El Hamdaoui, Pulin Che, Xueke Zhao, Rafael Grytz, Yiju Cheng, Qiang Ding, Meimei Wang, A. Brent Carter, Jennifer L. Larson-Casey
Publikováno v:
Laboratory Investigation. 101:116-124
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease without effective therapy. Animal models effectively reproducing IPF disease features are needed to study the underlying molecular mechanisms. Tree shrews are genetically, ana
Publikováno v:
J Biol Chem
Heavy metals released into the environment have a significant effect on respiratory health. Lung macrophages are important in mounting an inflammatory response to injury, but they are also involved in repair of injury. Macrophages develop mixed pheno
Autor:
Chao He, A. Brent Carter
Publikováno v:
Am J Respir Cell Mol Biol
Idiopathic pulmonary fibrosis (IPF) is a particularly deadly form of pulmonary fibrosis of unknown cause. In patients with IPF, high serum and lung concentrations of CHI3L1 (chitinase 3 like 1) can be detected and are associated with poor survival. H