Identifying latent disease factors differently expressed in patient subgroups using group factor analysis

Autor: Ferreira, Fabio S., Ashburner, John, Bouzigues, Arabella, Suksasilp, Chatrin, Russell, Lucy L., Foster, Phoebe H., Ferry-Bolder, Eve, van Swieten, John C., Jiskoot, Lize C., Seelaar, Harro, Sanchez-Valle, Raquel, Laforce, Robert, Graff, Caroline, Galimberti, Daniela, Vandenberghe, Rik, de Mendonca, Alexandre, Tiraboschi, Pietro, Santana, Isabel, Gerhard, Alexander, Levin, Johannes, Sorbi, Sandro, Otto, Markus, Pasquier, Florence, Ducharme, Simon, Butler, Chris R., Ber, Isabelle Le, Finger, Elizabeth, Tartaglia, Maria C., Masellis, Mario, Rowe, James B., Synofzik, Matthis, Moreno, Fermin, Borroni, Barbara, Kaski, Samuel, Rohrer, Jonathan D., Mourao-Miranda, Janaina

In this study, we propose a novel approach to uncover subgroup-specific and subgroup-common latent factors addressing the challenges posed by the heterogeneity of neurological and mental disorders, which hinder disease understanding, treatment develo

Externí odkaz: http://arxiv.org/abs/2410.07890

GP64-pseudotyped lentiviral vectors target liver endothelial cells and correct hemophilia A mice

Autor: Michela Milani, Cesare Canepari, Simone Assanelli, Simone Merlin, Ester Borroni, Francesco Starinieri, Mauro Biffi, Fabio Russo, Anna Fabiano, Desirèe Zambroni, Andrea Annoni, Luigi Naldini, Antonia Follenzi, Alessio Cantore

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1427-1450 (2024)

Abstract Lentiviral vectors (LV) are efficient vehicles for in vivo gene delivery to the liver. LV integration into the chromatin of target cells ensures their transmission upon proliferation, thus allowing potentially life-long gene therapy followin

Externí odkaz: https://doaj.org/article/b045f6dbf8624a8e8e0b19badc7c0b7b

Topical Pharmacological Treatment of Actinic Keratoses: Focus on Tirbanibulin 1% Ointment

Autor: Mario Valenti, Matteo Bianco, Alessandra Narcisi, Antonio Costanzo, Riccardo Borroni, Marco Ardigò

Publikováno v: Dermatology Practical & Conceptual, Vol 14, Iss S1 (2024)

Actinic keratosis (AK) is a frequent precancerous skin lesion that mostly affects chronically sun-exposed areas. Chronic sun damage leads to various mutations in onco-suppressor and oncogenic genes which cause an uncontrolled proliferation of atypica

Externí odkaz: https://doaj.org/article/00020d588e1b4882866fdb1d960dc710

Inflammatory plasma profile in genetic symptomatic and presymptomatic Frontotemporal Dementia − A GENFI study

Autor: Fenoglio, Chiara, Serpente, Maria, Arcaro, Marina, Carandini, Tiziana, Sacchi, Luca, Pintus, Manuela, Rotondo, Emanuela, Borracci, Vittoria, Ghezzi, Laura, Bouzigues, Arabella, Russell, Lucy L., Foster, Phoebe H., Ferry-Bolder, Eve, van Swieten, John C., Jiskoot, Lize C., Seelaar, Harro, Sánchez Valle, Raquel, Laforce, Robert, Graff, Caroline, Vandenberghe, Rik, de Mendonça, Alexandre, Tiraboschi, Pietro, Santana, Isabel, Gerhard, Alexander, Levin, Johannes, Sorbi, Sandro, Otto, Markus, Pasquier, Florence, Ducharme, Simon, Butler, Chris R., Ber, Isabelle Le, Finger, Elizabeth, Carmela Tartaglia, Maria, Masellis, Mario, Rowe, James B., Synofzik, Matthis, Moreno, Fermin, Borroni, Barbara, Rohrer, Jonathan D., Arighi, Andrea, Galimberti, Daniela

Publikováno v: In Brain Behavior and Immunity November 2024 122:231-240

A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors

Autor: Imogen J. Swift, Rosa Rademakers, NiCole Finch, Matt Baker, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Giacomina Rossi, Matthis Synofzik, Carlo Wilke, David Mengel, Caroline Graff, Leonel T. Takada, Raquel Sánchez-Valle, Anna Antonell, Daniela Galimberti, Chiara Fenoglio, Maria Serpente, Marina Arcaro, Stefanie Schreiber, Stefan Vielhaber, Philipp Arndt, Isabel Santana, Maria Rosario Almeida, Fermín Moreno, Myriam Barandiaran, Alazne Gabilondo, Johannes Stubert, Estrella Gómez-Tortosa, Pablo Agüero, M. José Sainz, Tomohito Gohda, Maki Murakoshi, Nozomu Kamei, Sarah Kittel-Schneider, Andreas Reif, Johannes Weigl, Jinlong Jian, Chuanju Liu, Ginette Serrero, Thomas Greither, Gerit Theil, Ebba Lohmann, Stefano Gazzina, Silvia Bagnoli, Giovanni Coppola, Amalia Bruni, Mirja Quante, Wieland Kiess, Andreas Hiemisch, Anne Jurkutat, Matthew S. Block, Aaron M. Carlson, Geir Bråthen, Sigrid Botne Sando, Gøril Rolfseng Grøntvedt, Camilla Lauridsen, Amanda Heslegrave, Carolin Heller, Emily Abel, Alba Gómez-Núñez, Roger Puey, Andrea Arighi, Enmanuela Rotondo, Lize C. Jiskoot, Lieke H. H. Meeter, João Durães, Marisa Lima, Miguel Tábuas-Pereira, João Lemos, Bradley Boeve, Ronald C. Petersen, Dennis W. Dickson, Neill R. Graff-Radford, Isabelle LeBer, Leila Sellami, Foudil Lamari, Fabienne Clot, Barbara Borroni, Valentina Cantoni, Jasmine Rivolta, Alberto Lleó, Juan Fortea, Daniel Alcolea, Ignacio Illán-Gala, Lucie Andres-Cerezo, Philip Van Damme, Jordi Clarimon, Petra Steinacker, Emily Feneberg, Markus Otto, Emma L. van der Ende, John C. van Swieten, Harro Seelaar, Henrik Zetterberg, Aitana Sogorb-Esteve, Jonathan D. Rohrer

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)

Abstract Background Pathogenic heterozygous mutations in the progranulin gene (GRN) are a key cause of frontotemporal dementia (FTD), leading to significantly reduced biofluid concentrations of the progranulin protein (PGRN). This has led to a number

Externí odkaz: https://doaj.org/article/1d7c751ac55c494a90e49ef788756561