Activation function 2 (AF2) of estrogen receptor-α is required for the atheroprotective action of estradiol but not to accelerate endothelial healing

Autor: Billon-Galés, Audrey, Krust, Andrée, Fontaine, Coralie, Abot, Anne, Flouriot, Gilles, Toutain, Céline, Berges, Hortense, Gadeau, Alain-Pierre, Lenfant, Françoise, Gourdy, Pierre, Chambon, Pierre, Arnal, Jean-François

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2011 Aug 01. 108(32), 13311-13316.

Externí odkaz: https://www.jstor.org/stable/27979187

Tamoxifen Elicits Atheroprotection through Estrogen Receptor α AF-1 But Does Not Accelerate Reendothelialization

Autor: Alexia Vinel, Anne Abot, Audrey Billon-Galés, Gilles Flouriot, Jean-François Arnal, Pierre Gourdy, Etienne Grunenwald, Coralie Fontaine, Hortense Bergès, Marie-Cécile Valéra

Publikováno v: American Journal of Pathology
American Journal of Pathology, American Society for Investigative Pathology, 2013, 183 (1), pp.304-12. ⟨10.1016/j.ajpath.2013.03.010⟩
American Journal of Pathology, 2013, 183 (1), pp.304-12. ⟨10.1016/j.ajpath.2013.03.010⟩

International audience; Based on both experimental and clinical data, tamoxifen has been proposed to have cardiovascular benefits, although the mechanism(s) contributing to that protective effect are still poorly understood. In vitro experiments demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7784a0cfc3185ca828f445dd17a19fbb
https://doi.org/10.1016/j.ajpath.2013.03.010

Activation function 2 (AF2) of estrogen receptor-{alpha} is required for the atheroprotective action of estradiol but not to accelerate endothelial healing

Autor: Andrée Krust, Pierre Chambon, Gilles Flouriot, Pierre Gourdy, Jean-François Arnal, Alain-Pierre Gadeau, Audrey Billon-Galés, Hortense Berges, Coralie Fontaine, Françoise Lenfant, Céline E. Toutain, Anne Abot

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (32), pp.13311-6. ⟨10.1073/pnas.1105632108⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (32), pp.13311-6. ⟨10.1073/pnas.1105632108⟩

17β-Estradiol (E2) regulates estrogen receptor-α (ERα) target gene transcription through the two independent activation functions (AFs), AF1 and AF2, located in the N-terminal and ligand binding domain of ERα, respectively. We previously reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33eaf92e7e3f3cab0472b6e3010ff6a1
https://www.hal.inserm.fr/inserm-00615519

Endothelial estrogen receptor {alpha} plays an essential role in the coronary and myocardial protective effects of estradiol in ischemia/reperfusion

Autor: Françoise Lenfant, Ji Gao, Isabelle Remy-Jouet, Isabelle Fourquaux, Jean-Paul Henry, Christian Thuillez, Julie Favre, Audrey Billon-Galés, Vincent Richard, Jean-François Arnal

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, 2010, 30 (12), pp.2562-7. ⟨10.1161/ATVBAHA.110.213637⟩
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2010, 30 (12), pp.2562-7. ⟨10.1161/ATVBAHA.110.213637⟩

Objective— To assess the coronary endothelial protective effects of 17β-estradiol (E2) and the role of estrogen receptor (ER) α in ischemia/reperfusion (I/R). Methods and Results— E2 exerts protective effects in cardiac I/R. However, the implic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b65cd1528d1715ee743c75ea358d590
https://www.hal.inserm.fr/inserm-00550876

Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice

Autor: Laurent Delpy, Coralie Fontaine, Jean-Charles Guéry, Audrey Billon-Galés, Bertrand Calippe, Victorine Douin-Echinard, Pierre Gourdy, Hortense Berges, Jean-François Arnal, Françoise Lenfant, Henrik Laurell

Publikováno v: Circulation
Circulation, American Heart Association, 2009, 120 (25), pp.2567-76. ⟨10.1161/CIRCULATIONAHA.109.898445⟩

Background— The prevention of early atheroma by estrogens has been clearly demonstrated in all animal models and appears to be mediated through a direct action on the arterial wall rather than through an effect on the lipoprotein profile. The goal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add20b06ec9963a0923a5e86c418944a
https://hal.archives-ouvertes.fr/hal-00458859