PARP1-dependent DNA-protein crosslink repair

Autor: Zita Fábián, Ellen S. Kakulidis, Ivo A. Hendriks, Ulrike Kühbacher, Nicolai B. Larsen, Marta Oliva-Santiago, Junhui Wang, Xueyuan Leng, A. Barbara Dirac-Svejstrup, Jesper Q. Svejstrup, Michael L. Nielsen, Keith Caldecott, Julien P. Duxin

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also inv

Externí odkaz: https://doaj.org/article/427734112e584ecc9b9b66e9b3111faa

MuCol Milestone Report No. 5: Preliminary Parameters

Autor: Accettura, Carlotta, Adrian, Simon, Agarwal, Rohit, Ahdida, Claudia, Aimé, Chiara, Aksoy, Avni, Alberghi, Gian Luigi, Alden, Siobhan, Alfonso, Luca, Amapane, Nicola, Amorim, David, Andreetto, Paolo, Anulli, Fabio, Appleby, Rob, Apresyan, Artur, Asadi, Pouya, Mahmoud, Mohammed Attia, Auchmann, Bernhard, Back, John, Badea, Anthony, Bae, Kyu Jung, Bahng, E. J., Balconi, Lorenzo, Balli, Fabrice, Bandiera, Laura, Barbagallo, Carmelo, Barlow, Roger, Bartoli, Camilla, Bartosik, Nazar, Barzi, Emanuela, Batsch, Fabian, Bauce, Matteo, Begel, Michael, Berg, J. Scott, Bersani, Andrea, Bertarelli, Alessandro, Bertinelli, Francesco, Bertolin, Alessandro, Bhat, Pushpalatha, Bianchi, Clarissa, Bianco, Michele, Bishop, William, Black, Kevin, Boattini, Fulvio, Bogacz, Alex, Bonesini, Maurizio, Bordini, Bernardo, de Sousa, Patricia Borges, Bottaro, Salvatore, Bottura, Luca, Boyd, Steven, Breschi, Marco, Broggi, Francesco, Brunoldi, Matteo, Buffat, Xavier, Buonincontri, Laura, Burrows, Philip Nicholas, Burt, Graeme Campbell, Buttazzo, Dario, Caiffi, Barbara, Calatroni, Sergio, Calviani, Marco, Calzaferri, Simone, Calzolari, Daniele, Cantone, Claudio, Capdevilla, Rodolfo, Carli, Christian, Carrelli, Carlo, Casaburo, Fausto, Casarsa, Massimo, Castelli, Luca, Catanesi, Maria Gabriella, Cavallucci, Lorenzo, Cavoto, Gianluca, Celiberto, Francesco Giovanni, Celona, Luigi, Cemmi, Alessia, Ceravolo, Sergio, Cerri, Alessandro, Cerutti, Francesco, Cesarini, Gianmario, Cesarotti, Cari, Chancé, Antoine, Charitonidis, Nikolaos, Chiesa, Mauro, Chiggiato, Paolo, Ciccarella, Vittoria Ludovica, Puviani, Pietro Cioli, Colaleo, Anna, Colao, Francesco, Collamati, Francesco, Costa, Marco, Craig, Nathaniel, Curtin, David, Damerau, Heiko, Da Molin, Giacomo, D'Angelo, Laura, Dasu, Sridhara, de Blas, Jorge, De Curtis, Stefania, De Gersem, Herbert, Delahaye, Jean-Pierre, Del Moro, Tommaso, Denisov, Dmitri, Denizli, Haluk, Dermisek, Radovan, Valdor, Paula Desiré, Desponds, Charlotte, Di Luzio, Luca, Di Meco, Elisa, Diociaiuti, Eleonora, Di Petrillo, Karri Folan, Di Sarcina, Ilaria, Dorigo, Tommaso, Dreimanis, Karlis, Pree, Tristan du, Yildiz, Hatice Duran, Edgecock, Thomas, Fabbri, Siara, Fabbrichesi, Marco, Farinon, Stefania, Ferrand, Guillaume, Somoza, Jose Antonio Ferreira, Fieg, Max, Filthaut, Frank, Fox, Patrick, Franceschini, Roberto, Ximenes, Rui Franqueira, Gallinaro, Michele, Garcia-Sciveres, Maurice, Garcia-Tabares, Luis, Gargiulo, Ruben, Garion, Cedric, Garzelli, Maria Vittoria, Gast, Marco, Generoso, Lisa, Gerber, Cecilia E., Giambastiani, Luca, Gianelle, Alessio, Gianfelice-Wendt, Eliana, Gibson, Stephen, Gilardoni, Simone, Giove, Dario Augusto, Giovinco, Valentina, Giraldin, Carlo, Glioti, Alfredo, Gorzawski, Arkadiusz, Greco, Mario, Grojean, Christophe, Grudiev, Alexej, Gschwendtner, Edda, Gueli, Emanuele, Guilhaudin, Nicolas, Han, Chengcheng, Han, Tao, Hauptman, John Michael, Herndon, Matthew, Hillier, Adrian D, Hillman, Micah, Holmes, Tova Ray, Homiller, Samuel, Jana, Sudip, Jindariani, Sergo, Johannesson, Sofia, Johnson, Benjamin, Jones, Owain Rhodri, Jurj, Paul-Bogdan, Kahn, Yonatan, Kamath, Rohan, Kario, Anna, Karpov, Ivan, Kelliher, David, Kilian, Wolfgang, Kitano, Ryuichiro, Kling, Felix, Kolehmainen, Antti, Kong, K. C., Kosse, Jaap, Krintiras, Georgios, Krizka, Karol, Kumar, Nilanjana, Kvikne, Erik, Kyle, Robert, Laface, Emanuele, Lane, Kenneth, Latina, Andrea, Lechner, Anton, Lee, Junghyun, Lee, Lawrence, Lee, Seh Wook, Lefevre, Thibaut, Leonardi, Emanuele, Lerner, Giuseppe, Li, Peiran, Li, Qiang, Li, Tong, Li, Wei, Lindroos, Mats, Lipton, Ronald, Liu, Da, Liu, Miaoyuan, Liu, Zhen, Voti, Roberto Li, Lombardi, Alessandra, Lomte, Shivani, Long, Kenneth, Longo, Luigi, Lorenzo, José, Losito, Roberto, Low, Ian, Lu, Xianguo, Lucchesi, Donatella, Luo, Tianhuan, Lupato, Anna, Ma, Yang, Machida, Shinji, Madlener, Thomas, Magaletti, Lorenzo, Maggi, Marcello, Durand, Helene Mainaud, Maltoni, Fabio, Manczak, Jerzy Mikolaj, Mandurrino, Marco, Marchand, Claude, Mariani, Francesco, Marin, Stefano, Mariotto, Samuele, Martin-Haugh, Stewart, Masullo, Maria Rosaria, Mauro, Giorgio Sebastiano, Mazzolari, Andrea, Mękała, Krzysztof, Mele, Barbara, Meloni, Federico, Meng, Xiangwei, Mentink, Matthias, Métral, Elias, Miceli, Rebecca, Milas, Natalia, Mohammadi, Abdollah, Moll, Dominik, Montella, Alessandro, Morandin, Mauro, Morrone, Marco, Mulder, Tim, Musenich, Riccardo, Nardecchia, Marco, Nardi, Federico, Nenna, Felice, Neuffer, David, Newbold, David, Novelli, Daniel, Olvegård, Maja, Onel, Yasar, Orestano, Domizia, Osborne, John, Otten, Simon, Torres, Yohan Mauricio Oviedo, Paesani, Daniele, Griso, Simone Pagan, Pagani, Davide, Pal, Kincso, Palmer, Mark, Pampaloni, Alessandra, Panci, Paolo, Pani, Priscilla, Papaphilippou, Yannis, Paparella, Rocco, Paradisi, Paride, Passeri, Antonio, Pasternak, Jaroslaw, Pastrone, Nadia, Pellecchia, Antonello, Piccinini, Fulvio, Piekarz, Henryk, Pieloni, Tatiana, Plouin, Juliette, Portone, Alfredo, Potamianos, Karolos, Potdevin, Joséphine, Prestemon, Soren, Puig, Teresa, Qiang, Ji, Quettier, Lionel, Rabemananjara, Tanjona Radonirina, Radicioni, Emilio, Radogna, Raffaella, Rago, Ilaria Carmela, Ratkus, Andris, Resseguie, Elodie, Reuter, Juergen, Ribani, Pier Luigi, Riccardi, Cristina, Ricciardi, Stefania, Robens, Tania, Robert, Youri, Rogers, Chris, Rojo, Juan, Romagnoni, Marco, Ronald, Kevin, Rosser, Benjamin, Rossi, Carlo, Rossi, Lucio, Rozanov, Leo, Ruhdorfer, Maximilian, Ruiz, Richard, Saini, Saurabh, Sala, Filippo, Salierno, Claudia, Salmi, Tiina, Salvini, Paola, Salvioni, Ennio, Sammut, Nicholas, Santini, Carlo, Saputi, Alessandro, Sarra, Ivano, Scarantino, Giuseppe, Schneider-Muntau, Hans, Schulte, Daniel, Scifo, Jessica, Sen, Tanaji, Senatore, Carmine, Senol, Abdulkadir, Sertore, Daniele, Sestini, Lorenzo, Rêgo, Ricardo César Silva, Simone, Federica Maria, Skoufaris, Kyriacos, Sorbello, Gino, Sorbi, Massimo, Sorti, Stefano, Soubirou, Lisa, Spataro, David, Queiroz, Farinaldo S., Stamerra, Anna, Stapnes, Steinar, Stark, Giordon, Statera, Marco, Stechauner, Bernd Michael, Su, Shufang, Su, Wei, Sun, Xiaohu, Sytov, Alexei, Tang, Jian, Tang, Jingyu, Taylor, Rebecca, Kate, Herman Ten, Testoni, Pietro, Thiele, Leonard Sebastian, Garcia, Rogelio Tomas, Topp-Mugglestone, Max, Torims, Toms, Torre, Riccardo, Tortora, Luca, Tortora, Ludovico, Trifinopoulos, Sokratis, Udongwo, Sosoho-Abasi, Vai, Ilaria, Valente, Riccardo Umberto, van Rienen, Ursula, Van Weelderen, Rob, Vanwelde, Marion, Velev, Gueorgui, Venditti, Rosamaria, Vendrasco, Adam, Verna, Adriano, Vernassa, Gianluca, Verweij, Arjan, Verwilligen, Piet, Villamizar, Yoxara, Vittorio, Ludovico, Vitulo, Paolo, Vojskovic, Isabella, Wang, Dayong, Wang, Lian-Tao, Wang, Xing, Wendt, Manfred, Widorski, Markus, Wozniak, Mariusz, Wu, Yongcheng, Wulzer, Andrea, Xie, Keping, Yang, Yifeng, Yap, Yee Chinn, Yonehara, Katsuya, Yoo, Hwi Dong, You, Zhengyun, Zanetti, Marco, Zaza, Angela, Zhang, Liang, Zhu, Ruihu, Zlobin, Alexander, Zuliani, Davide, Zurita, José Francisco

This document is comprised of a collection of updated preliminary parameters for the key parts of the muon collider. The updated preliminary parameters follow on from the October 2023 Tentative Parameters Report. Particular attention has been given t

Externí odkaz: http://arxiv.org/abs/2411.02966

Telescope-to-Fireball Characterization of Earth Impactor 2022 WJ1

Autor: Kareta, Theodore, Vida, Denis, Micheli, Marco, Moskovitz, Nicholas, Wiegert, Paul, Brown, Peter G., McCausland, Phil J. A., Devillpoix, Hadrien A. R., Malečić, Barbara, Prtenjak, Maja Telišman, Śegon, Damir, Shafransky, Benjamin, Farnocchia, Davide

Comparing how an asteroid appears in space to its ablation behavior during atmospheric passage and finally to the properties of associated meteorites represents the ultimate probe of small near-Earth objects. We present observations from the Lowell D

Externí odkaz: http://arxiv.org/abs/2411.14595

A Wearable Gait Monitoring System for 17 Gait Parameters Based on Computer Vision

Autor: Chen, Jiangang, Sun, Yung-Hong, Pickett, Kristen, King, Barbara, Hu, Yu Hen, Jiang, Hongrui

We developed a shoe-mounted gait monitoring system capable of tracking up to 17 gait parameters, including gait length, step time, stride velocity, and others. The system employs a stereo camera mounted on one shoe to track a marker placed on the opp

Externí odkaz: http://arxiv.org/abs/2411.10739

AI and the Future of Work in Africa White Paper

Autor: O'Neill, Jacki, Marivate, Vukosi, Glover, Barbara, Karanu, Winnie, Tadesse, Girmaw Abebe, Gyekye, Akua, Makena, Anne, Rosslyn-Smith, Wesley, Grollnek, Matthew, Wayua, Charity, Baguma, Rehema, Maduke, Angel, Spencer, Sarah, Kandie, Daniel, Maari, Dennis Ndege, Mutangana, Natasha, Axmed, Maxamed, Kamau, Nyambura, Adamu, Muhammad, Swaniker, Frank, Gatuguti, Brian, Donner, Jonathan, Graham, Mark, Mumo, Janet, Mbindyo, Caroline, N'Guessan, Charlette, Githinji, Irene, Makhafola, Lesego, Kruger, Sean, Etyang, Olivia, Onando, Mulang, Sevilla, Joe, Sambuli, Nanjira, Mbaya, Martin, Breloff, Paul, Anapey, Gideon M., Mogaleemang, Tebogo L., Nghonyama, Tiyani, Wanyoike, Muthoni, Mbuli, Bhekani, Nderu, Lawrence, Nyabero, Wambui, Alam, Uzma, Olaleye, Kayode, Njenga, Caroline, Sellen, Abigail, Kairo, David, Chabikwa, Rutendo, Abdulhamid, Najeeb G., Kubasu, Ketry, Okolo, Chinasa T., Akpo, Eugenia, Budu, Joel, Karambal, Issa, Berkoh, Joseph, Wasswa, William, Njagwi, Muchai, Burnet, Rob, Ochanda, Loise, de Bod, Hanlie, Ankrah, Elizabeth, Kinyunyu, Selemani, Kariuki, Mutembei, Kiyimba, Kizito, Eleshin, Farida, Madeje, Lillian Secelela, Muraga, Catherine, Nganga, Ida, Gichoya, Judy, Maina, Tabbz, Maina, Samuel, Mercy, Muchai, Ochieng, Millicent, Nyairo, Stephanie

This white paper is the output of a multidisciplinary workshop in Nairobi (Nov 2023). Led by a cross-organisational team including Microsoft Research, NEPAD, Lelapa AI, and University of Oxford. The workshop brought together diverse thought-leaders f

Externí odkaz: http://arxiv.org/abs/2411.10091