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Akademický článek

Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients

Autor: L. Griffin, L. Ho, R. J. Akhurst, S. T. Arron, J. M. E. Boggs, P. Conlon, P. O’Kelly, A. E. Toland, E. H. Epstein, A. Balmain, B. C. Bastian, F. J. Moloney, G. M. Murphy, M. E. Laing

Publikováno v: Skin Health and Disease, Vol 2, Iss 2, Pp n/a-n/a (2022)

Abstract Background Renal transplant recipients (RTRs) are at increased risk of keratinocyte cancer (KC), especially cutaneous squamous cell carcinoma (cSCC). Previous studies identified a genetic variant of the Methylenetetrahydrofolate Reductase (M

Externí odkaz: https://doaj.org/article/96bb0e3338d646bf83ec68ce94af6bf5

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Akademický článek

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Background Checkpoint blockade immunotherapy has improved metastatic cancer patient survival, but response rates remain low. There is an unmet need to identify mechanisms and tools to circumvent resistance. In human patients, responses to ch

Externí odkaz: https://doaj.org/article/4fe6933efb37461d998179c6fde2d077

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Akademický článek

A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross miceResearch in context

Autor: Hui Yang, Xinzhi Wang, Adrián Blanco-Gómez, Li He, Natalia García-Sancha, Roberto Corchado-Cobos, Manuel Jesús Pérez-Baena, Alejandro Jiménez-Navas, Pin Wang, Jamie L. Inman, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Hang Chang, Jesus Perez-Losada, Jian-Hua Mao

Publikováno v: EBioMedicine, Vol 106, Iss , Pp 105260- (2024)

Summary: Background: Deeper insights into ERBB2-driven cancers are essential to develop new treatment approaches for ERBB2+ breast cancers (BCs). We employed the Collaborative Cross (CC) mouse model to unearth genetic factors underpinning Erbb2-drive

Externí odkaz: https://doaj.org/article/6fe0af1cc003460fbba638da01b6d216

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Akademický článek

Comparing the Physiological Responses to the 6-Minute Walk Test, Timed Up and Go Test, and Treadmill Cardiopulmonary Exercise Test

Autor: Eduardo S. Alves, R. Nicole Bellet, Pramod Sharma, Bryce N. Balmain, Craig Aitken, Thomas Doering, Leilani Orola, Anita Green, Tatiana Paim, Fergus O’Connor, Norman R. Morris

Publikováno v: Rehabilitation Research and Practice, Vol 2024 (2024)

Conclusion: Not surprisingly, the treadmill CPX results is the greatest physiological response in our group. Despite being of short duration, the TUGT results in an increased physiological response.

Externí odkaz: https://doaj.org/article/e51b0b9fde1f4fa8bc3ea0779fe74d5a

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