Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

Autor: Kassiani Kytidou, Thomas J. M. Beenakker, Lotte B. Westerhof, Cornelis H. Hokke, Geri F. Moolenaar, Nora Goosen, Mina Mirzaian, Maria J. Ferraz, Mark de Geus, Wouter W. Kallemeijn, Herman S. Overkleeft, Rolf G. Boot, Arjen Schots, Dirk Bosch, Johannes M. F. G. Aerts

Publikováno v: Frontiers in Plant Science, Vol 8 (2017)

Deficiency of α-galactosidase A (α-GAL) causes Fabry disease (FD), an X-linked storage disease of the glycosphingolipid globtriaosylcerammide (Gb3) in lysosomes of various cells and elevated plasma globotriaosylsphingosine (Lyso-Gb3) toxic for podo

Externí odkaz: https://doaj.org/article/65d83c0c2ed34ed3bbeb8805c99ee953

Conserved codon adaptation in highly expressed genes is associated with higher regularity in mRNA secondary structures

Autor: Lotte B. Westerhof, George M. Giambaşu, Johannes Helder, Pjotr Prins, Jaap Bakker, Basten L. Snoek, Ruud H. P. Wilbers, Jan E. Kammenga, Martijn Holterman, Mark G. Sterken, E.J. Slootweg, Arjen Schots

The redundancy of the genetic code allows for a regulatory layer to optimize protein synthesis by modulating translation and degradation of mRNAs. Patterns in synonymous codon usage in highly expressed genes have been studied in many species, but sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e3d12b66bb67b3697cf7f5e4a9f7b7a
https://doi.org/10.1101/2020.11.23.393322

The N-glycan on Asn54 affects the atypical N-glycan composition of plant-produced interleukin-22, but does not influence its activity

Autor: Lauri Reuter, Geert Smant, Arjen Schots, Cornelis H. Hokke, Jose L. Lozano-Torres, Lotte B. Westerhof, Alexandra Castilho, Dieu Linh Nguyen, Jaap Bakker, Debbie R. van Raaij, Ruud H. P. Wilbers

Publikováno v: Plant Biotechnology Journal, 14(2), 670-681
Wilbers, R H P, Westerhof, L B, Reuter, L J, Castilho, A, van Raaij, D R, Nguyen, D L, Lozano-Torres, J L, Smant, G, Hokke, C H, Bakker, J & Schots, A 2016, ' The N-glycan on Asn54 affects the atypical N-glycan composition of plant-produced interleukin-22, but does not influence its activity ', Plant Biotechnology Journal, vol. 14, no. 2, pp. 670-681 . https://doi.org/10.1111/pbi.12414
Plant Biotechnology Journal 14 (2016) 2

Human interleukin-22 (IL-22) is a member of the IL-10 cytokine family that has recently been shown to have major therapeutic potential. IL-22 is an unusual cytokine as it does not act directly on immune cells. Instead, IL-22 controls the differentiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5537f68c2587cf304d52cd77ebd5b911
https://doi.org/10.1111/pbi.12414

GM-CSF negatively regulates early IL-10 mediated responses

Autor: Lotte B. Westerhof, Debbie R. van Raaij, Geert Smant, Arjen Schots, Jaap Bakker, Ruud H. P. Wilbers

Inflammatory disorders are becoming more prevalent in the Western world. Treatment of these diseases relies on the intervention in inflammatory responses thereby restoring immune homeostasis. One cytokine that has the potential to restore immune home

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b16f32735c431da5c337a1c2bd0dd5
https://doi.org/10.1101/202317

Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells

Autor: Lotte B. Westerhof, Astrid Voskamp, Simone Haeberlein, Arjen Schots, Louis Boon, Luciën E. P. M. van der Vlugt, Cornelis H. Hokke, Mathilde A. M. Chayé, Ruud H. P. Wilbers, Henrike Veninga, Katja Obieglo, Arifa Ozir-Fazalalikhan, Joke M. M. den Haan, Hermelijn H. Smits, Gabriele Schramm

Publikováno v: PLoS Pathogens, 13(7):e1006539. Public Library of Science
PLoS Pathogens 13 (2017) 7
PLoS Pathogens
Haeberlein, S, Obieglo, K, Ozir-Fazalalikhan, A, Chayé, M A M, Veninga, H, van der Vlugt, L E P M, Voskamp, A, Boon, L, den Haan, J M M, Westerhof, L B, Wilbers, R H P, Schots, A, Schramm, G, Hokke, C H & Smits, H H 2017, ' Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells ', PLoS Pathogens, vol. 13, no. 7, e1006539 . https://doi.org/10.1371/journal.ppat.1006539
PLoS Pathogens, Vol 13, Iss 7, p e1006539 (2017)
PLoS Pathogens, 13(7)

Infection with the helminth Schistosoma (S.) mansoni drives the development of interleukin (IL)-10-producing regulatory B (Breg) cells in mice and man, which have the capacity to reduce experimental allergic airway inflammation and are thus of high t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a772baca302f65d6bb7500e5e3b636
https://doi.org/10.1371/journal.ppat.1006539