Zobrazeno 1 - 10
of 22
pro vyhledávání: '"A. B. Vassos"'
Autor:
Christine W. Alvey, Jeffrey R. Koup, Edward J. Randinitis, Allen J. Sedman, Cho-Ming Loi, Artemios B. Vassos
Publikováno v:
The Journal of Clinical Pharmacology. 39:920-926
This study evaluated the steady-state pharmacokinetics and dose proportionality of troglitazone, metabolite 1 (sulfate conjugate), and metabolite 3 (quinone metabolite) following administration of daily oral doses of 200, 400, and 600mg troglitazonef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bc2ceff0076cac82169458abece081
https://doi.org/10.1177/00912709922008533
https://doi.org/10.1177/00912709922008533
Autor:
Jeffrey R. Koup, Robert A. Blum, Cho-Ming Loi, Allen J. Sedman, Joanne I. Brodfuehrer, Artemios B. Vassos, Philip W. Knowlton, Edward J. Randinitis
Publikováno v:
Clinical Drug Investigation. 17:127-136
Objective: The pharmacokinetic profiles of troglitazone and two metabolites were evaluated following a single 400mg oral dose of troglitazone in 20 patients with various degrees of renal function. Methods: Plasma troglitazone and metabolite concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3107bd8f7b6f5ccace585ec5c949ab17
https://doi.org/10.2165/00044011-199917020-00007
https://doi.org/10.2165/00044011-199917020-00007
Publikováno v:
Clinical Pharmacokinetics. 37:91-104
Troglitazone is a new thiazolidinedione oral antidiabetic agent approved for use to improve glycaemic control in patients with type 2 diabetes. It is rapidly absorbed with an absolute bioavailability of between 40 and 50%. Food increases the absorpti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a48deeb8aa2857e5b3cead247929e3
https://doi.org/10.2165/00003088-199937020-00001
https://doi.org/10.2165/00003088-199937020-00001
Publikováno v:
Journal of Antimicrobial Chemotherapy. 38:1023-1029
The single-dose tolerance and pharmacokinetics of clinafloxacin, a new fluoroquinolone antibacterial agent. were evaluated in healthy volunteers. Single oral doses of 25, 50, 100, and 200 mg were well tolerated. Adverse events after placebo and clina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6609ece4930aa6eef595638e86b7017
https://doi.org/10.1093/jac/38.6.1023
https://doi.org/10.1093/jac/38.6.1023
Autor:
Christine Alvey, Neil J. Hounslow, George Rausch, Allen J. Sedman, Edward J. Randinitis, Nicola J. Bron, Jeffery R. Koup, Robert Abel, Artemios B. Vassos
Many fluoroquinolone antibiotics are inhibitors of cytochrome P450 enzyme systems and may produce potentially important drug interactions when administered with other drugs. Studies were conducted to determine the effect of clinafloxacin on the pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f266c2298c8ee437c267e39a0bad45f0
https://europepmc.org/articles/PMC90690/
https://europepmc.org/articles/PMC90690/
Autor:
George Rausch, Nicola J. Bron, Allen J. Sedman, Edward J. Randinitis, Neil J. Hounslow, Jeffery R. Koup, Robert Abel, Artemios B. Vassos
As the primary route for elimination of clinafloxacin is renal clearance (CL R ) of unchanged drug, studies were conducted to determine the pharmacokinetic profile of clinafloxacin following administration to young and elderly subjects, subjects with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8622350735e505d36e18561d5d513bf
https://europepmc.org/articles/PMC90689/
https://europepmc.org/articles/PMC90689/
Publikováno v:
Antimicrobial agents and chemotherapy. 45(9)
Clinafloxacin (CI-960) is a potent broad-spectrum, fluoroquinolone antibiotic that has been studied for parenteral and oral administration in patients with serious infections. The objectives of these studies were to examine the pharmacokinetics and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003bcc7d428dccbd60244073694cbca8
https://pubmed.ncbi.nlm.nih.gov/11502525
https://pubmed.ncbi.nlm.nih.gov/11502525
Autor:
Cho Ming Loi, Ralph H. Stern, Jeffrey R. Koup, Allen J. Sedman, Artemios B. Vassos, Philip W. Knowlton
Publikováno v:
Journal of clinical pharmacology. 39(4)
Fifteen healthy women participated in a study to determine the effect of multiple doses of troglitazone on the pharmacokinetics of Ortho-Novum 1/35 (35 micrograms ethinyl estradiol [EE] and 1 mg norethindrone [NE]). Participants received three cycles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0967a3027e27ef0541c723b70acdc304
https://pubmed.ncbi.nlm.nih.gov/10197300
https://pubmed.ncbi.nlm.nih.gov/10197300
Publikováno v:
Advances in experimental medicine and biology. 431
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4e3d42e5c3f675d8a123bd48869d1ac
https://pubmed.ncbi.nlm.nih.gov/9598026
https://pubmed.ncbi.nlm.nih.gov/9598026
Autor:
Edward J. Randinitis, Cho Ming Loi, Allen J. Sedman, Artemios B. Vassos, Ralph H. Stern, Philip W. Knowlton, Jeffrey R. Koup
Publikováno v:
Journal of clinical pharmacology. 38(2)
Twelve healthy subjects participated in a study to determine the effect of multiple doses of troglitazone on the steady-state pharmacokinetics of digoxin. Subjects received digoxin 0.25 mg orally once daily on days 1 through 20 and 400 mg of troglita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dea6dfeef07cd3bb7f9285e601dd971
https://pubmed.ncbi.nlm.nih.gov/9549650
https://pubmed.ncbi.nlm.nih.gov/9549650