Zobrazeno 1 - 10
of 25
pro vyhledávání: '"A. B. Shanafelt"'
Autor:
Candice Y. Li, Holly A. Bina, Eric D. Berglund, Armen B. Shanafelt, David H. Wasserman, M. Dodson Michael, Alexei Kharitonenkov, Sara E. Lynes
Publikováno v:
Endocrinology. 150:4084-4093
Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator shown to improve glycemic control. However, the molecular and functional mechanisms underlying FGF21-mediated improvements in glycemic control are not completely understood. We examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa62adf01cab722820d90b460e3e2a9
https://doi.org/10.1210/en.2009-0221
https://doi.org/10.1210/en.2009-0221
Publikováno v:
BioDrugs. 22:37-44
Fibroblast growth factor (FGF)-21 is a unique member of the FGF family, with several molecular characteristics that differ from classical FGFs and exhibiting a pharmacologic profile that includes a variety of metabolic responses in vitro and when tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d16e1dbd6ec733ce16c0b2b92819d2c
https://doi.org/10.2165/00063030-200822010-00004
https://doi.org/10.2165/00063030-200822010-00004
Autor:
Armen B. Shanafelt, John Michael Beals
Publikováno v:
Drug Discovery Today: Technologies. 3:87-94
Therapeutic proteins have made a major impact on medicine, with significant expansion in the past two decades. The medicinal attributes of these agents, particularly their efficacy and often their safety profile, make protein therapeutics attractive,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d750c7846c1cd0ad2d836e1de8a0622
https://doi.org/10.1016/j.ddtec.2006.03.001
https://doi.org/10.1016/j.ddtec.2006.03.001
Autor:
George Georgiou, Raymond A. Hui, Barrett R. Harvey, Brent L. Iverson, Armen B. Shanafelt, Steve Vitone, Irina Baburina
Publikováno v:
Journal of Immunological Methods. 308:43-52
The detection of methamphetamine and other chemically related illicit drugs relies extensively on immunoassays. Here we report the cloning and affinity maturation of an anti-methamphetamine antibody which is being employed in the current commercial a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aec1846c18ca635e245aa9abfac18cd
https://doi.org/10.1016/j.jim.2005.09.017
https://doi.org/10.1016/j.jim.2005.09.017
Autor:
Dagmar Ringe, Gregory A. Petsko, Armen B. Shanafelt, Mark A. Wilson, E. Pozharski, A. Hewagama
Publikováno v:
Journal of Molecular Biology. 337:691-697
The crystal structures of an anti-morphine antibody 9B1 (to 1.6A resolution) and its complex with morphine (to 2.0 A resolution) are reported. The morphine-binding site is described as a shallow depression on the protein surface, an unusual topology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376fdf2a44f379105fdca1a3652437e7
https://doi.org/10.1016/j.jmb.2003.12.084
https://doi.org/10.1016/j.jmb.2003.12.084
Autor:
A. B. Shanafelt
Publikováno v:
Current Pharmaceutical Biotechnology. 4:1-20
Cytokines hold huge potential for the treatment of disease due to their often fundamental roles in development and homeostasis. However, it is this same primary biological function that can both cause disease through dysregulation as well as prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3640a1f0e8a7410fd28a77c05a0a345
https://doi.org/10.2174/1389201033378066
https://doi.org/10.2174/1389201033378066
Autor:
Armen B Shanafelt
Publikováno v:
Expert Opinion on Biological Therapy. 5:149-151
Proteins that are normally present in organisms function to maintain the overall homeostatic balance of the living system. Although an understanding of the biology of these proteins is essential to determining their utility in the treatment of diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589f39b18d685747988549a2a7b01887
https://doi.org/10.1517/14712598.5.2.149
https://doi.org/10.1517/14712598.5.2.149
Autor:
Edward A. Clark, Andrew W. Heath, Charles Hannum, David Campbell, Ray Chang, Nobuyuki Harada, Raul M. Torres, Leopoldo Santos-Argumedo, Maureen Howard, John R. Gordon, Armen B. Shanafelt
Publikováno v:
Cellular Immunology. 152:468-480
A rat anti-mouse CD40 antiserum has been prepared by hyperimmunisation of Lewis rats with a highly purified preparation of the recombinant extracellular domain of murine CD40. This antiserum specifically binds CD40-expressing L cell transfectants, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671849810c1a04d88655fa40e69e0876
https://doi.org/10.1006/cimm.1993.1305
https://doi.org/10.1006/cimm.1993.1305
Autor:
A B Shanafelt, R A Kastelein
Publikováno v:
Journal of Biological Chemistry. 267:25466-25472
The high affinity receptor of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is a heterodimer composed of two members of the cytokine receptor superfamily. GM-CSF binds to the alpha-subunit (GM-R alpha) with low affinity and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::541beba84561a3c3353280778187ca58
https://doi.org/10.1016/s0021-9258(19)74064-2
https://doi.org/10.1016/s0021-9258(19)74064-2
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 10(4)
The increasing prevalence of metabolic diseases is alarming and highlights the need for more effective and safer therapies to treat these diseases. Recent evidence from several animal studies indicates that FGF21 induces numerous beneficial metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92b97aec6f29ba62f5ec813d733fe7a8
https://pubmed.ncbi.nlm.nih.gov/19337957
https://pubmed.ncbi.nlm.nih.gov/19337957