Zobrazeno 1 - 10
of 343
pro vyhledávání: '"A. B. Rickinson"'
Autor:
Neil M. Steven, Alan B. Rickinson, Anthony T. C. Chan, Edwin P. Hui, Steve Wilson, Andrew Hartley, Lesley McGuigan, Ceri Edwards, Claudia Roberts, Jen Matthews, Manjit Tanday, David A. Price, Kristin Ladell, James Turner, Lip Wai Lee, Kevin Harrington, Hui Jia, Graham S. Taylor
Additional detail of materials and methods used. Figure 1. Flow chart detailing dose escalation schema. Figure 2. MVA-EBNA1/LMP2 Vaccination does not alter broad subsets of immune cells. Figure 3. EBNA1 antibody response before and after MVA-EL vacci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac23961963214984f8aa7aeec4fdeb5e
https://doi.org/10.1158/1078-0432.22459926.v1
https://doi.org/10.1158/1078-0432.22459926.v1
Autor:
Neil M. Steven, Alan B. Rickinson, Anthony T. C. Chan, Edwin P. Hui, Steve Wilson, Andrew Hartley, Lesley McGuigan, Ceri Edwards, Claudia Roberts, Jen Matthews, Manjit Tanday, David A. Price, Kristin Ladell, James Turner, Lip Wai Lee, Kevin Harrington, Hui Jia, Graham S. Taylor
Purpose: Epstein–Barr virus (EBV) is associated with several cancers in which the tumor cells express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost immunity to these tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303abaf52c2dfc85fef0a8480919683b
https://doi.org/10.1158/1078-0432.c.6524349
https://doi.org/10.1158/1078-0432.c.6524349
Autor:
Anthony T.C. Chan, Neil M. Steven, Alan B. Rickinson, Deborah D. Stocken, Ceri Edwards, Benjamin F. Johnson, Steven Wilson, Wai-Lap Wong, Rosalie Ho, Stephen L. Chan, Brigette B.Y. Ma, Hui Jia, Graham S. Taylor, Edwin P. Hui
PDF file - 269K, Additional detail of methodology, adverse events, epitope peptides and epitope-specific T cell responses. Also includes all results obtained using ELIspot assays with overlapping peptides and analysis of regulatory T cells in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d257043b2e9d9c45c55735f9ff7faeb
https://doi.org/10.1158/0008-5472.22399679.v1
https://doi.org/10.1158/0008-5472.22399679.v1
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007110 (2018)
Human herpesviruses are antigenically rich agents that induce strong CD8+T cell responses in primary infection yet persist for life, continually challenging T cell memory through recurrent lytic replication and potentially influencing the spectrum of
Externí odkaz:
https://doaj.org/article/bd1cf1b4ea61478e9b3ba8c3151e0e7a
Autor:
Heng Giap Woon, Asolina Braun, Jane Li, Corey Smith, Jarem Edwards, Frederic Sierro, Carl G Feng, Rajiv Khanna, Michael Elliot, Andrew Bell, Andrew D Hislop, Stuart G Tangye, Alan B Rickinson, Thomas Gebhardt, Warwick J Britton, Umaimainthan Palendira
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005799 (2016)
Disruption of T cell memory during severe immune suppression results in reactivation of chronic viral infections, such as Epstein Barr virus (EBV) and Cytomegalovirus (CMV). How different subsets of memory T cells contribute to the protective immunit
Externí odkaz:
https://doaj.org/article/552bcd3b75c8474db486435ca84dbb1b
Autor:
Jill M Brooks, Heather M Long, Rose J Tierney, Claire Shannon-Lowe, Alison M Leese, Martin Fitzpatrick, Graham S Taylor, Alan B Rickinson
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005549 (2016)
Epstein-Barr virus, a B-lymphotropic herpesvirus, is the cause of infectious mononucleosis, has strong aetiologic links with several malignancies and has been implicated in certain autoimmune diseases. Efforts to develop a prophylactic vaccine to pre
Externí odkaz:
https://doaj.org/article/1dfc125317dd48d1bfb10be0d65fcd47
Autor:
Shamanthi Jayasooriya, Thushan I de Silva, Jainaba Njie-jobe, Chilel Sanyang, Alison M Leese, Andrew I Bell, Karen A McAulay, Peng Yanchun, Heather M Long, Tao Dong, Hilton C Whittle, Alan B Rickinson, Sarah L Rowland-Jones, Andrew D Hislop, Katie L Flanagan
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004746 (2015)
Epstein-Barr virus (EBV) infection often occurs in early childhood and is asymptomatic. However, if delayed until adolescence, primary infection may manifest as acute infectious mononucleosis (AIM), a febrile illness characterised by global CD8+ T-ce
Externí odkaz:
https://doaj.org/article/9f7656ff746e49acba6b99d0dc0a6fc4
Autor:
Alan B. Rickinson, M.A. Epstein
Epstein–Barr virus is a human herpesvirus with a linear double-stranded DNA genome that is carried asymptomatically by most people. Symptomless primary infection is usual in childhood, establishing a lifelong carrier state where the virus persists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe94ceeba8acaa73ab8ee8109e33e8dd
https://doi.org/10.1093/med/9780198746690.003.0078
https://doi.org/10.1093/med/9780198746690.003.0078
Autor:
Emily Heath, Noelia Begue-Pastor, Sridhar Chaganti, Debbie Croom-Carter, Claire Shannon-Lowe, Dieter Kube, Regina Feederle, Henri-Jacques Delecluse, Alan B Rickinson, Andrew I Bell
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002697 (2012)
Epstein-Barr virus (EBV), a lymphomagenic human herpesvirus, colonises the host through polyclonal B cell-growth-transforming infections yet establishes persistence only in IgD⁺ CD27⁺ non-switched memory (NSM) and IgD⁻ CD27⁺ switched memory (
Externí odkaz:
https://doaj.org/article/ed4f30f2a0934f5cad9fcf65c29bad6a
Autor:
Umaimainthan Palendira, Carol Low, Anna Chan, Andrew D Hislop, Edwin Ho, Tri Giang Phan, Elissa Deenick, Matthew C Cook, D Sean Riminton, Sharon Choo, Richard Loh, Frank Alvaro, Claire Booth, H Bobby Gaspar, Alessandro Moretta, Rajiv Khanna, Alan B Rickinson, Stuart G Tangye
Publikováno v:
PLoS Biology, Vol 9, Iss 11, p e1001187 (2011)
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP. SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors. A defining feature of XLP is exquisite
Externí odkaz:
https://doaj.org/article/2f8dac67c92b469bb76a09f459caef5b