Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C

Autor: Aline B. Maddux, Cameron C. Young, Suden Kucukak, Laura D. Zambrano, Margaret M. Newhams, Caitlin K. Rollins, Natasha B. Halasa, Shira J. Gertz, Elizabeth H. Mack, Stephanie Schwartz, Michele Kong, Laura L. Loftis, Katherine Irby, Courtney M. Rowan, Keiko M. Tarquinio, Matt S. Zinter, Hillary Crandall, Natalie Z. Cvijanovich, Jennifer E. Schuster, Julie C. Fitzgerald, Mary A. Staat, Charlotte V. Hobbs, Ryan A. Nofziger, Steven Shein, Heidi Flori, Melissa L. Cullimore, Brandon M. Chatani, Emily R. Levy, Katri V. Typpo, Janet R. Hume, Angela P. Campbell, Adrienne G. Randolph, the Overcoming COVID-19 Investigators, Meghan Murdock, Heather Kelley, Candice Colston, Mary Glas Gaspers, Ronald C. Sanders, Emily Port, Rachel Mansour, Sara Shankman, Kaitlin Jones, Caitlin Rollins, Tanya Novak, Janet Chou, Mary Beth Son, Julia Clarke, Brooke Sens, Eve Listerud, Sabrina Chen, Kasey Stewart, Heidi R. Flori, Mary K. Dahmer, Supriya Behl, Noelle M. Drapeau, Lora Martin, Lacy Malloch, Maygan Martin, Kayla Patterson, Cameron Sanders, Kengo Inagaki, Sarah McGraw, Anita Dhanrajani, Abigail Kietzman, Shannon Hill, Russell J. McCulloh, Stephanie P. Schwartz, Tracie C. Walker, Mary Allen Staat, Rajashri Rasal, Ryan Burnett, Jenny Bush, Meena Golcha, Laura Stewart, Krow Ampofo, Manish M. Patel, Leora R. Feldstein, Mark W. Tenforde, Ashley M. Jackson, Angela Campbell

Publikováno v: Frontiers in Pediatrics, Vol 11 (2023)

ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. O

Externí odkaz: https://doaj.org/article/1e2f7cbc16d047dbab50b8aeff084f5e

Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C

Autor: Juanjie Tang, Tanya Novak, Julian Hecker, Gabrielle Grubbs, Fatema Tuz Zahra, Lorenza Bellusci, Sara Pourhashemi, Janet Chou, Kristin Moffitt, Natasha B. Halasa, Stephanie P. Schwartz, Tracie C. Walker, Keiko M. Tarquinio, Matt S. Zinter, Mary A. Staat, Shira J. Gertz, Natalie Z. Cvijanovich, Jennifer E. Schuster, Laura L. Loftis, Bria M. Coates, Elizabeth H. Mack, Katherine Irby, Julie C. Fitzgerald, Courtney M. Rowan, Michele Kong, Heidi R. Flori, Aline B. Maddux, Steven L. Shein, Hillary Crandall, Janet R. Hume, Charlotte V. Hobbs, Adriana H. Tremoulet, Chisato Shimizu, Jane C. Burns, Sabrina R. Chen, Hye Kyung Moon, Christoph Lange, Adrienne G. Randolph, Surender Khurana

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

The antibody response to the SARS-CoV-2 Omicron variant is not well studied in children. Here, the authors provide an age-stratified analysis of SARS-CoV-2 neutralizing capacity of sera from children with acute or convalescent COVID-19 as well as chi

Externí odkaz: https://doaj.org/article/e95d32cb646c4ee9abe90f1a0721b0aa

Lower respiratory tract infections in children requiring mechanical ventilation: a multicentre prospective surveillance study incorporating airway metagenomics

Autor: Alexandra Tsitsiklis, PhD, Christina M Osborne, MD, Jack Kamm, PhD, Kayla Williamson, MS, Katrina Kalantar, PhD, Gytis Dudas, PhD, Saharai Caldera, BA, Amy Lyden, BA, Michelle Tan, BS, Norma Neff, PhD, Victoria Soesanto, BS, J Kirk Harris, PhD, Lilliam Ambroggio, PhD, Aline B Maddux, MD, Todd C Carpenter, MD, Ron W Reeder, PhD, Chris Locandro, MS, Eric A F Simões, ProfMD, Matthew K Leroue, MD, Mark W Hall, ProfMD, Athena F Zuppa, ProfMD, Joseph Carcillo, ProfMD, Kathleen L Meert, ProfMD, Anil Sapru, ProfMD, Murray M Pollack, ProfMD, Patrick S McQuillen, ProfMD, Daniel A Notterman, ProfMD, J Michael Dean, ProfMD, Matt S Zinter, MD, Brandie D Wagner, PhD, Joseph L DeRisi, ProfPhD, Peter M Mourani, ProfMD, Charles R Langelier, MDPhD

Publikováno v: The Lancet Microbe, Vol 3, Iss 4, Pp e284-e293 (2022)

Summary: Background: Lower respiratory tract infections (LRTI) are a leading cause of critical illness and mortality in mechanically ventilated children; however, the pathogenic microbes frequently remain unknown. We combined traditional diagnostics

Externí odkaz: https://doaj.org/article/bf9afb105f554ba7841ff015408ec805

Unplanned Admissions, Emergency Department Visits, and Epilepsy After Critical Neurological Illness Requiring Prolonged Mechanical Ventilation in Children

Autor: Matthew B. Spear, Kristen Miller, Craig Press, Christopher Ruzas, Jaime LaVelle, Peter M. Mourani, Tellen D. Bennett, Aline B. Maddux

Publikováno v: The Neurohospitalist. 13(1)

Background and Purpose Long-term outcomes after pediatric neurocritical illness are poorly characterized. This study aims to characterize the frequency and risk factors for post-discharge unplanned health resource use in a pediatric neurocritical car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b1185359c0f86cbb68e8d4bfd21169
https://pubmed.ncbi.nlm.nih.gov/36531841

Outcomes of Critically Ill Children With Acute Lymphoblastic Leukemia and Cytokine Release Syndrome Due to Chimeric Antigen Receptor T Cell Therapy: US, Multicenter PICU, Cohort Database Study

Autor: Grace E, Logan, Kristen, Miller, M Eric, Kohler, Michele, Loi, Aline B, Maddux

Publikováno v: Pediatric Critical Care Medicine. 23:e595-e600

Cytokine release syndrome (CRS) is a potentially lethal toxicity associated with chimeric antigen receptor T cell therapy for pediatric acute lymphoblastic leukemia (ALL). Outcomes after critical illness due to severe CRS are poorly described. Our ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dfd58ed1a1fc50f380cae4e08228b5
https://doi.org/10.1097/pcc.0000000000003079