Zobrazeno 1 - 10
of 10
pro vyhledávání: '"A. B. LIBERACKI"'
Publikováno v:
Toxicological Sciences. 53:400-410
Human sperm count studies, historic dietary iodination, and an animal model where neonatal goitrogen administration causes unprecedented testis enlargement, together suggest an hypothesis relevant to the postulated fall in human sperm counts. We pres
Autor:
A. B. Liberacki, J. Hellwig
Publikováno v:
Fundamental and Applied Toxicology. 40:158-162
Pregnant Wistar rats (40/group) were administered monoethanolamine (MEA) as an aqueous solution by gavage at dose levels of 0, 40, 120, and 450 mg/kg/day on days 6 through 15 of gestation. On day 20 of gestation, 25 dams/group were euthanized and the
Publikováno v:
Toxicological Sciences. 31:117-123
Publikováno v:
Fundamental and Applied Toxicology. 29:119-130
Chlorpyrifos (O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphorothioate), an organophosphate insecticide, was evaluated for its potential to produce developmental and reproductive toxicity in rats following oral exposure. Pregnant Fischer 344 rats w
Publikováno v:
Teratology. 53:38-46
The effects of ethylene glycol (EG) and its metabolite, glycolic acid (GA), were compared by culturing day 10.5 rat conceptuses for 46 h in media containing 0.5, 2.5, 12.5, 25 or 50 mM EG or GA. EG up to 50 mM was essentially without effect, whereas
Autor:
Richard A. Gies, Kristine G. Studniski, Karl K. Weitz, Edward W. Carney, Belen Tornesi, Richard A. Corley, Daniel A. Markham, John C. Blessing, Teressa M. Luders, A. B. Liberacki
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 119(1)
High-dose bolus exposure of rats to ethylene glycol (EG) causes developmental toxicity mediated by a metabolite, glycolic acid (GA), whose levels increase disproportionately when its metabolism is saturated. However, low-level exposures that do not s
Autor:
Belen Tornesi, Edward W. Carney, Lynn H. Pottenger, A. B. Liberacki, M. D. Dryzga, Steven C. Hansen, William J. Breslin, Keith A. Johnson
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 71(2)
Commercial grade propylene glycol monomethyl ether (PGME), which is composed of > 99.5% alpha-isomer and < 0.5% beta-isomer, has been shown in several studies to have a low potential for developmental toxicity. Nonetheless, questions have been raised
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 50(2)
This study evaluated propylene glycol monomethyl ether (PGME) in a rat 2-generation reproduction study, which included non-traditional study end points, such as sperm count and motility, developmental landmarks, estrous cyclicity, and weanling organ
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 31(1)
Pregnant Sprague-Dawley rats and New Zealand White rabbits were exposed dermally to 0, 10, 25, and 75 mg/kg/day of monoethanolamine (MEA) for approximately 6 hr/day on Days 6 through 15 (rats) or 6 through 18 (rabbits) of gestation. A fifth dose grou
Publikováno v:
Teratology. 53(1)
The effects of ethylene glycol (EG) and its metabolite, glycolic acid (GA), were compared by culturing day 10.5 rat conceptuses for 46 h in media containing 0.5, 2.5, 12.5, 25 or 50 mM EG or GA. EG up to 50 mM was essentially without effect, whereaso