Zobrazeno 1 - 10
of 664
pro vyhledávání: '"A. B. Kohn"'
Autor:
Paul G. Ayoub, Julia Gensheimer, Lindsay Lathrop, Colin Juett, Jason Quintos, Kevin Tam, Jack Reid, Feiyang Ma, Curtis Tam, Grace E. McAuley, Devin Brown, Xiaomeng Wu, Ruixue Zhang, Kathryn Bradford, Roger P. Hollis, Gay M. Crooks, Donald B. Kohn
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101323- (2024)
X-linked lymphoproliferative disease (XLP1) results from SH2D1A gene mutations affecting the SLAM-associated protein (SAP). A regulated lentiviral vector (LV), XLP-SMART LV, designed to express SAP at therapeutic levels in T, NK, and NKT cells, is cr
Externí odkaz:
https://doaj.org/article/af4d633eb4eb4c8ea8d67abff5e5fe26
Autor:
Michael D. Keller, Patrick J. Hanley, Yueh-Yun Chi, Paibel Aguayo-Hiraldo, Christopher C. Dvorak, Michael R. Verneris, Donald B. Kohn, Sung-Yun Pai, Blachy J. Dávila Saldaña, Benjamin Hanisch, Troy C. Quigg, Roberta H. Adams, Ann Dahlberg, Shanmuganathan Chandrakasan, Hasibul Hasan, Jemily Malvar, Mariah A. Jensen-Wachspress, Christopher A. Lazarski, Gelina Sani, John M. Idso, Haili Lang, Pamela Chansky, Chase D. McCann, Jay Tanna, Allistair A. Abraham, Jennifer L. Webb, Abeer Shibli, Amy K. Keating, Prakash Satwani, Pawel Muranski, Erin Hall, Michael J. Eckrich, Evan Shereck, Holly Miller, Ewelina Mamcarz, Rajni Agarwal, Satiro N. De Oliveira, Mark T. Vander Lugt, Christen L. Ebens, Victor M. Aquino, Jeffrey J. Bednarski, Julia Chu, Suhag Parikh, Jennifer Whangbo, Michail Lionakis, Elias T. Zambidis, Elizabeth Gourdine, Catherine M. Bollard, Michael A. Pulsipher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter stud
Externí odkaz:
https://doaj.org/article/fcdca2f7424c452f994b7e545a14509b
Autor:
S. Pischke, E. V. Knoop, M. Mader, L. Kling, A. Wolski, A. Wagner, K. Mueller, T. Horvatits, J. Stiller, K. Wisnewski, B. Kohn, J. Schulze zur Wiesch, M. H. Groschup, M. Eiden
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Hepatitis E virus (HEV) genotype 3 infections in Germany are mainly transmitted zoonotically through the consumption of swine meat. Furthermore, there is evidence that pets might come into contact with HEV, but the relevance of companion ani
Externí odkaz:
https://doaj.org/article/6964d4da43c4414c8eaf7d4f73de10ec
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 28-39 (2023)
Integrating vectors are associated with alterations in cellular function related to disruption of normal gene function. This has been associated with clonal expansion of cells and, in some instances, cancer. These events have been associated with rep
Externí odkaz:
https://doaj.org/article/42f5707d16174ef1bfd32620b4e99f73
Autor:
Noah Dillon, Ben Cocanougher, Chhavi Sood, Xin Yuan, Andrea B Kohn, Leonid L Moroz, Sarah E Siegrist, Marta Zlatic, Chris Q. Doe
Publikováno v:
Neural Development, Vol 17, Iss 1, Pp 1-18 (2022)
Abstract The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features of the Drosophila larval CNS across several key developmental timepoints. We identify multi
Externí odkaz:
https://doaj.org/article/e780c550fa4c4dd183447840043947f4
Autor:
Marc Corrales, Benjamin T. Cocanougher, Andrea B. Kohn, Jason D. Wittenbach, Xi S. Long, Andrew Lemire, Albert Cardona, Robert H. Singer, Leonid L. Moroz, Marta Zlatic
Publikováno v:
Neural Development, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Molecular profiles of neurons influence neural development and function but bridging the gap between genes, circuits, and behavior has been very difficult. Here we used single cell RNAseq to generate a complete gene expression atlas of the D
Externí odkaz:
https://doaj.org/article/8da66f866b114055b6916e18666e7aca
Autor:
S. Pischke, E. V. Knoop, M. Mader, L. Kling, A. Wolski, A. Wagner, K. Mueller, T. Horvatits, J. Stiller, K. Wisnewski, B. Kohn, J. Schulze zur Wiesch, M. H. Groschup, M. Eiden
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/1608250fd1bf470283eb310f0751f47f
Autor:
Záfia R Gonçalves, Alana B. Kohn, Saulo D. Silva, Barbara A. Louback, Lívia C.M. Velasco, Erika Cesar O. Naliato, Mauro Geller
Publikováno v:
DST, Vol 24, Iss 1 (2023)
Introduction: the human immunodeficiency virus (HIV) epidemic began in the 1980’s. As there were no therapeutic options at that time, diagnosed patients evolved rapidly to death. With the implementation of anti-retroviral therapy in 1996, HIV infec
Externí odkaz:
https://doaj.org/article/a549ce41109b44b5a384ad25df9ef9dd
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 582-592 (2021)
Lentiviral vectors (LVs) are robust delivery vehicles for gene therapy as they can efficiently integrate transgenes into host cell genomes. However, LVs with lengthy or complex expression cassettes typically are produced at low titers and have reduce
Externí odkaz:
https://doaj.org/article/8d9f5440d6cd42d0a5f0940f9f1a0fa1
Autor:
Mohamed Abou-el-Enein, Aris Angelis, Frederick R. Appelbaum, Nancy C. Andrews, Susan E. Bates, Arlene S. Bierman, Malcolm K. Brenner, Marina Cavazzana, Michael A. Caligiuri, Hans Clevers, Emer Cooke, George Q. Daley, Victor J. Dzau, Lee M. Ellis, Harvey V. Fineberg, Lawrence S.B. Goldstein, Stephen Gottschalk, Margaret A. Hamburg, Donald E. Ingber, Donald B. Kohn, Adrian R. Krainer, Marcela V. Maus, Peter Marks, Christine L. Mummery, Roderic I. Pettigrew, Joni L. Rutter, Sarah A. Teichmann, Andre Terzic, Fyodor D. Urnov, David A. Williams, Jedd D. Wolchok, Mark Lawler, Cameron J. Turtle, Gerhard Bauer, John P.A. Ioannidis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 11-14 (2021)
Externí odkaz:
https://doaj.org/article/c3fa45c6e32349f68ffd7fcab701dc16