Zobrazeno 1 - 10
of 178
pro vyhledávání: '"A. B. Hjelmeland"'
Autor:
Jennifer L. Fisher, Elizabeth J. Wilk, Vishal H. Oza, Sam E. Gary, Timothy C. Howton, Victoria L. Flanary, Amanda D. Clark, Anita B. Hjelmeland, Brittany N. Lasseigne
Publikováno v:
FEBS Open Bio, Vol 14, Iss 5, Pp 803-830 (2024)
Drug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease‐associated gene signature to identi
Externí odkaz:
https://doaj.org/article/f40949cccc344b50a5660d71408edfbd
Autor:
Cyntanna C. Hawkins, Amber B. Jones, Emily R. Gordon, Yuvika Harsh, Julia K. Ziebro, Christopher D. Willey, Corinne Griguer, David K. Crossman, Sara J. Cooper, Sasanka Ramanadham, Ninh Doan, Anita B. Hjelmeland
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Sphingolipid metabolism is dysregulated in many cancers, allowing cells to evade apoptosis through increased sphingosine-1-phosphate (S1P) and decreased ceramides. Ceramidases hydrolyze ceramides to sphingosine, which is phosphorylated by sp
Externí odkaz:
https://doaj.org/article/968cfb928d054a14a0cfa5059517fa60
Autor:
Sajina GC, Kaysaw Tuy, Lucas Rickenbacker, Robert Jones, Asmi Chakraborty, C. Ryan Miller, Elizabeth A. Beierle, Vidya Sagar Hanumanthu, Anh N. Tran, James A. Mobley, Susan L. Bellis, Anita B. Hjelmeland
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
One of the least-investigated areas of brain pathology research is glycosylation, which is a critical regulator of cell surface protein structure and function. β-Galactoside α2,6-sialyltransferase (ST6GAL1) is the primary enzyme that α2,6 sialylat
Externí odkaz:
https://doaj.org/article/cf92d181c1a04f8787c7b10cecb716a3
Autor:
Amber B. Jones, Taylor L. Schanel, Mikayla R. Rigsby, Corinne E. Griguer, Braden C. McFarland, Joshua C. Anderson, Christopher D. Willey, Anita B. Hjelmeland
Publikováno v:
Cells, Vol 12, Iss 17, p 2171 (2023)
Treatment for the deadly brain tumor glioblastoma (GBM) has been improved through the non-invasive addition of alternating electric fields, called tumor treating fields (TTFields). Improving both progression-free and overall survival, TTFields are cu
Externí odkaz:
https://doaj.org/article/19c6825befad40668d16c836d7cbcc8d
Autor:
Christian T. Stackhouse, Joshua C. Anderson, Zongliang Yue, Thanh Nguyen, Nicholas J. Eustace, Catherine P. Langford, Jelai Wang, James R. Rowland IV, Chuan Xing, Fady M. Mikhail, Xiangqin Cui, Hasan Alrefai, Ryan E. Bash, Kevin J. Lee, Eddy S. Yang, Anita B. Hjelmeland, C. Ryan Miller, Jake Y. Chen, G. Yancey Gillespie, Christopher D. Willey
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Key molecular regulators of acquired radiation resistance in recurrent glioblastoma (GBM) are largely unknown, with a dearth of accurate preclinical models. To address this, we generated 8 GBM patient-derived xenograft (PDX) models of acquired radiat
Externí odkaz:
https://doaj.org/article/f06e9a8597724e01bcfa17bb759ec86f
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The Golgi-sialyltransferase ST6Gal1 (βgalactosidase α2,6 sialyltransferase 1), adds the negatively charged sugar, sialic acid, to the terminal galactose of N-glycosylated proteins. Upregulation of ST6Gal1 is observed in many malignancies, and a lar
Externí odkaz:
https://doaj.org/article/1b2ddec1d8914695a72f871864b8169e
Autor:
Catherine J Libby, Sajina Gc, Gloria A. Benavides, Jennifer L. Fisher, Sarah E. Williford, Sixue Zhang, Anh Nhat Tran, Emily R. Gordon, Amber B. Jones, Kaysaw Tuy, William Flavahan, Juan Gordillo, Ashlee Long, Sara J. Cooper, Brittany N. Lasseigne, Corinne E. Augelli-Szafran, Victor Darley-Usmar, Anita B. Hjelmeland
Publikováno v:
Cell Adhesion & Migration, Vol 15, Iss 1, Pp 101-115 (2021)
The multifaceted roles of metabolism in invasion have been investigated across many cancers. The brain tumor glioblastoma (GBM) is a highly invasive and metabolically plastic tumor with an inevitable recurrence. The neuronal glucose transporter 3 (GL
Externí odkaz:
https://doaj.org/article/8ae81f05eb1749278b5439e70c0972a8
Autor:
Yichen Guo, Yinan Jiang, J. Bart Rose, Ganji Purnachandra Nagaraju, Renata Jaskula-Sztul, Anita B. Hjelmeland, Adam W. Beck, Herbert Chen, Bin Ren
Publikováno v:
Cells, Vol 11, Iss 23, p 3885 (2022)
Pancreatic neuroendocrine tumors (pNETs) are extremely diverse and highly vascularized neoplasms that arise from endocrine cells in the pancreas. The pNETs harbor a subpopulation of stem cell-like malignant cells, known as cancer stem cells (CSCs), w
Externí odkaz:
https://doaj.org/article/ff6f6e403cb140bfb558440ffe4a02a2
Publikováno v:
Redox Biology, Vol 44, Iss , Pp 101953- (2021)
Controlling reactive oxygen species (ROS) at sustainable levels can drive multiple facets of tumor biology, including within the cancer stem cell (CSC) population. Tight regulation of ROS is one key component in CSCs that drives disease recurrence, c
Externí odkaz:
https://doaj.org/article/a2e4b062b5a746059e639a3ae34e831a
Autor:
Kaitlyn A. Dorsett, Robert B. Jones, Katherine E. Ankenbauer, Anita B. Hjelmeland, Susan L. Bellis
Publikováno v:
Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Background The ST6Gal-I glycosyltransferase, which adds α2–6-linked sialic acids to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian cancer. Prior studies have shown that ST6Gal-I-mediated sialylati
Externí odkaz:
https://doaj.org/article/b818a3a798914e8fa50cea2b13d78301