Zobrazeno 1 - 10
of 1 505
pro vyhledávání: '"A. B. Higgins"'
Autor:
Jiameng Sun, Yiming Zhang, Joshua A. Adams, Cassandra B. Higgins, Shannon C. Kelly, Hao Zhang, Kevin Y. Cho, Ulysses G. Johnson, Benjamin M. Swarts, Shun-Ichi Wada, Gary J. Patti, Leah P. Shriver, Brian N. Finck, Erik D. Herzog, Brian J. DeBosch
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114865- (2024)
Summary: Organisms integrate circadian and metabolic signals to optimize substrate selection to survive starvation, yet precisely how this occurs is unclear. Here, we show that hepatocyte Period 1 (Per1) is selectively induced during fasting, and mic
Externí odkaz:
https://doaj.org/article/f3f84b6930c6468d8267aafa1547506a
Autor:
Yiming Zhang, Jiameng Sun, Henry D. Wasserman, Joshua A. Adams, Cassandra B. Higgins, Shannon C. Kelly, Louise Lantier, Brian J. DeBosch
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 5, Pp 801-820 (2024)
Background & Aims: Restoring hepatic and peripheral insulin sensitivity is critical to prevent or reverse metabolic syndrome and type 2 diabetes. Glucose homeostasis comprises in part the complex regulation of hepatic glucose production and insulin-m
Externí odkaz:
https://doaj.org/article/c22f4337f0d34c74a26c716f33616718
Autor:
Timothy B. Higgins, Aneesh C. Subramanian, Andre Graubner, Lukas Kapp‐Schwoerer, Peter A. G. Watson, Sarah Sparrow, Karthik Kashinath, Sol Kim, Luca Delle Monache, Will Chapman
Publikováno v:
Journal of Advances in Modeling Earth Systems, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract There is currently large uncertainty over the impacts of climate change on precipitation trends over the US west coast. Atmospheric rivers (ARs) are a significant source of US west coast precipitation and trends in ARs can provide insight in
Externí odkaz:
https://doaj.org/article/4b94c1fd094b4bcea6effe0fa9dcc650
Autor:
S. Lee Ware, Christina R. Studts, Feitong Lei, Heather Bush, Eric B. Higgins, Jamie L. Studts, Ana Bastos de Carvalho
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Diabetic retinopathy (DR) is a leading cause of blindness worldwide, despite easy detection and effective treatment. Annual screening rates in the USA remain low, especially for the disadvantaged, which telemedicine-based DR scree
Externí odkaz:
https://doaj.org/article/c6e83d55520d46db9ad11e5899b1eeea
Autor:
Cassandra B. Higgins, Allyson L. Mayer, Yiming Zhang, Michael Franczyk, Samuel Ballentine, Jun Yoshino, Brian J. DeBosch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
NAD + metabolism is potential target to treat metabolic disorders, in part due to the effects of the NAD + dependent enzyme Sirt1. Here the authors report that hepatic nicotinamide phosphoribosyltransferase, a rate-limiting step in the NAD + salvage
Externí odkaz:
https://doaj.org/article/a90017de3aab45c5bda37c839a089c2e
Autor:
Ana Bastos de Carvalho, S. Lee Ware, Tamara Belcher, Franceska Mehmeti, Eric B. Higgins, Rob Sprang, Cody Williams, Jamie L. Studts, Christina R. Studts
Publikováno v:
Implementation Science Communications, Vol 2, Iss 1, Pp 1-13 (2021)
Abstract Background Recommended annual diabetic retinopathy (DR) screening for people with diabetes has low rates in the USA, especially in underserved populations. Telemedicine DR screening (TDRS) in primary care clinics could expand access and incr
Externí odkaz:
https://doaj.org/article/f4ad91aba5134b06b4c3269bc880add3
Autor:
Xiaohui Feng, Mian Li, Haili Liu, Paul B. Higgins, Yan Tang, Yun Cao, Jing Shen, Shuyan Jin, Sheng Ge
Publikováno v:
NFS Journal, Vol 19, Iss , Pp 1-8 (2020)
Background: Elevated circulating post–meal triglyceride concentrations or postprandial triglyceride (ppTG) is an independent contributor to risk for coronary heart disease. Reliable ppTG reduction can be achieved by lowering the fat content of inge
Externí odkaz:
https://doaj.org/article/cf7ebedab2ba4ae4899f39e20d093447
Autor:
Yiming Zhang, Cassandra B. Higgins, Hannah M. Fortune, Phillip Chen, Alicyn I. Stothard, Allyson L. Mayer, Benjamin M. Swarts, Brian J. DeBosch
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Fasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the re
Externí odkaz:
https://doaj.org/article/954749bafaf0425d8c21a4c09fdcf947
Autor:
Helena Earl, Louise Hiller, Anne-Laure Vallier, Shrushma Loi, Karen McAdam, Luke Hughes-Davies, Daniel Rea, Donna Howe, Kerry Raynes, Helen B Higgins, Maggie Wilcox, Chris Plummer, Betania Mahler-Araujo, Elena Provenzano, Anita Chhabra, Sophie Gasson, Claire Balmer, Jean E Abraham, Carlos Caldas, Peter Hall, Bethany Shinkins, Christopher McCabe, Claire Hulme, David Miles, Andrew M Wardley, David A Cameron, Janet A Dunn
Publikováno v:
Health Technology Assessment, Vol 24, Iss 40 (2020)
Background: The addition of adjuvant trastuzumab to chemotherapy has significantly improved outcomes for people with human epidermal growth factor receptor 2 (HER2)-positive, early, potentially curable breast cancer. Twelve months’ trastuzumab, tes
Externí odkaz:
https://doaj.org/article/66820d8dae1b478ea55fa5063313fffe
Autor:
Ana Bastos de Carvalho, S Lee Ware, Feitong Lei, Heather M Bush, Robert Sprang, Eric B Higgins
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241767 (2020)
ContextDiabetic retinopathy (DR) is the leading cause of incident blindness among working-age adults in the United States. Federally designated safety-net clinics (FDSC) often serve as point-of-contact for patients least likely to receive recommended
Externí odkaz:
https://doaj.org/article/90d2661bc3874f20a0ba4ac198f1e276