Zobrazeno 1 - 10
of 21
pro vyhledávání: '"A. B. Bruskin"'
Publikováno v:
Ведомости Научного центра экспертизы средств медицинского применения, Vol 12, Iss 3, Pp 244-262 (2022)
The main quality attributes of radiopharmaceuticals that ensure their effectiveness and safety and are unique to their specifications are activity, radionuclide identity, radionuclide purity, and radiochemical purity. The aim of this study was to ana
Externí odkaz:
https://doaj.org/article/a4f3031f1c134419ae60f457ce88ba24
Autor:
O. E. Klementyeva, A. B. Bruskin, K. A. Lunyova, V. B. Bubenshchikov, K. E. Ternovskaya, A. S. Lunev, G. E. Kodina
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 9, Iss 4, Pp 66-71 (2020)
Introduction. Skin cancers came first in Russia in numbers of oncological diseases. Melanoma, making up only a small part of these cases, leads to the most serious consequences. The nuclear medicine methods application is necessary at the stages of c
Externí odkaz:
https://doaj.org/article/5f1fdf0ea27146ad9e7fc4618bff78b5
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 9, Iss 3, Pp 166-171 (2020)
Introduction. The early detection of tumor growth remains one of the most important tasks of diagnostic nuclear medicine. The vascular growth being created malignant neoplasms is a good target for the purpose. The molecular participants in the proces
Externí odkaz:
https://doaj.org/article/c7a209bd797d409cb0e5ffc68c0d14b5
Autor:
V. S. Kuz'min, Svyatoslav A. Shevelev, Alexander Kh. Shakhnes, Victor V. Semenov, Alexander B. Bruskin
Publikováno v:
Chemistry of Heterocyclic Compounds. 53:728-732
N,N'-Dinitromethyl derivatives of 5,5'-dinitrobi(1,2,4-triazole) and 5,5'-dinitrobi(1,2,3-triazole) were used in a sequence of nitration, fluorination, and difluoroamination reactions, providing the respective 2,2'-bis(trinitromethyl)-, 2,2'-bis(dini
Publikováno v:
Radiochemistry. 58:506-512
Conditions allowing preparation of 68Ga complexes with RGD peptide derivatives with no less than 95% radiochemical purity were determined. The complexes are stable in blood plasma for the time sufficient for performing a diagnostic investigation.
Publikováno v:
Russian Chemical Bulletin. 65:363-383
The literature data on the application and synthetic methods of compounds for imaging and therapy of malignant foci characterized by the increased angiogenesis are summarized.
Preparation of highly purified 68Ga solutions via ion exchange in hydrochloric acid–ethanol mixtures
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 305:147-160
The ion-exchange behavior of 68Ga in mixed HCl–ethanol media on cation and anion exchangers was studied. The mass distribution coefficients of 68Ga on Dowex 50 W × 8 and Dowex 1 × 8 ion-exchange resins at HCl concentrations in the range 0.1–3.0
Publikováno v:
Radiochemistry. 56:57-65
Ion-exchange behavior of 68Ga in the mixed HCl-acetone medium on cation and anion exchangers was studied. The equilibrium gravimetric distribution coefficients of 68Ga on Dowex AG 50W×8 strongly acidic cation exchanger in the H+ form and on Dowex AG
Publikováno v:
Radiochemistry. 53:341-353
Today the main radionuclide used for preparing radiopharmaceuticals throughout the world is 99m Tc, thanks to its optimal nuclear-physical characteristics and ready availability. Several approaches are used for tethering this radionuclide to biomolec
Autor:
A. B. Bruskin, Victor V. Semenov, M. I. Kanishchev, Svyatoslav A. Shevelev, A. T. Baryshnikov
Publikováno v:
Russian Chemical Bulletin. 58:2077-2096
A general synthetic procedure for the synthesis of N-dinitromethyl derivatives of nitrogen-containing heterocycles has been developed. The procedure includes the destructive nitration of heterocyclic N-acetonyl derivatives of tetrazoles, 1,2,4- and 1