Zobrazeno 1 - 10
of 115
pro vyhledávání: '"A. Aziz Aboobaker"'
Autor:
Marta Iglesias, Daniel A. Felix, Óscar Gutiérrez-Gutiérrez, Maria del Mar De Miguel-Bonet, Sounak Sahu, Beatriz Fernández-Varas, Rosario Perona, A. Aziz Aboobaker, Ignacio Flores, Cristina González-Estévez
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 405-418 (2019)
Summary: Reduction of caloric intake delays and prevents age-associated diseases and extends the life span in many organisms. It may be that these benefits are due to positive effects of caloric restriction on stem cell function. We use the planarian
Externí odkaz:
https://doaj.org/article/12104bd543f34db3a68faa6d3c7cc333
Autor:
Yuliana Mihaylova, Prasad Abnave, Damian Kao, Samantha Hughes, Alvina Lai, Farah Jaber-Hijazi, Nobuyoshi Kosaka, A. Aziz Aboobaker
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The Mll3/4 histone methyltransferases can act as tumour suppressors in humans. Here, the authors identify three orthologs of mammalian MLL3/4 in the planarian Schmidtea mediterranea and show that knockdown causes outgrowths in regenerating animals, s
Externí odkaz:
https://doaj.org/article/d6b21974aa2f41b0889a0c888a7d36c3
Autor:
Katherine S. Bridge, Kunal M. Shah, Yigen Li, Daniel E. Foxler, Sybil C.K. Wong, Duncan C. Miller, Kathryn M. Davidson, John G. Foster, Ruth Rose, Michael R. Hodgkinson, Paulo S. Ribeiro, A. Aziz Aboobaker, Kenta Yashiro, Xiaozhong Wang, Paul R. Graves, Michael J. Plevin, Dimitris Lagos, Tyson V. Sharp
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 173-187 (2017)
As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assemb
Externí odkaz:
https://doaj.org/article/dd86764956e7461fbbd192078a7216b7
Autor:
Alvina G. Lai, A. Aziz Aboobaker
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-26 (2017)
Abstract Background Growing global demands for crustacean food crop species have driven large investments in aquaculture research worldwide. However, large-scale production is susceptible to pathogen-mediated destruction particularly in developing ec
Externí odkaz:
https://doaj.org/article/6dffba37b32f4847ab639308b169b933
Autor:
Alvina G. Lai, Natalia Pouchkina-Stantcheva, Alessia Di Donfrancesco, Gerda Kildisiute, Sounak Sahu, A. Aziz Aboobaker
Publikováno v:
BMC Evolutionary Biology, Vol 17, Iss 1, Pp 1-21 (2017)
Abstract Background Most animals employ telomerase, which consists of a catalytic subunit known as the telomerase reverse transcriptase (TERT) and an RNA template, to maintain telomere ends. Given the importance of TERT and telomere biology in core m
Externí odkaz:
https://doaj.org/article/03ab141171624bb3bb6f4cfaa7f6369e
Publikováno v:
PeerJ, Vol 2, p e382 (2014)
The immune system of the horse has not been well studied, despite the fact that the horse displays several features such as sensitivity to bacterial lipopolysaccharide that make them in many ways a more suitable model of some human disorders than the
Externí odkaz:
https://doaj.org/article/0e63485c745e447c9d80534dd7eaea8f
Publikováno v:
PLoS ONE, Vol 8, Iss 11 (2013)
Externí odkaz:
https://doaj.org/article/9f34134c22ff427da5538c6c3e6d28a4
Most multicellular organisms reproduce sexually despite the costs associated with sexuality1. This has been explained as the result of selection favouring the ability to recombine the genome. The lack of recombination in asexual species constrains th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40dcf49a499a9cdd02b355c8c181df1
https://doi.org/10.1101/2023.03.20.533553
https://doi.org/10.1101/2023.03.20.533553
Planarians have become an established model system to study regeneration and stem cells, but the regulatory elements in the genome remain almost entirely undescribed. Here, by integrating epigenetic and expression data we use multiple sources of evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec400d3be6bd493a485577646a0f66cc
https://ora.ox.ac.uk/objects/uuid:678c5f48-ff45-457c-93df-a8a54e2d9089
https://ora.ox.ac.uk/objects/uuid:678c5f48-ff45-457c-93df-a8a54e2d9089
The impacts of resource availability on senescence –the loss of vitality with age– are formalised under the Calorie Restriction (CR) theory, which predicts that the onset of senescence is delayed and life expectancy prolonged due to the ultimate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15861d264a6404a970cc3c9552932dac
https://doi.org/10.1101/2023.01.12.523873
https://doi.org/10.1101/2023.01.12.523873