Zobrazeno 1 - 10
of 18
pro vyhledávání: '"A. Ayanna Wade"'
Autor:
Jessica L. Haigh, Anna Adhikari, Nycole A. Copping, Tyler Stradleigh, A. Ayanna Wade, Rinaldo Catta-Preta, Linda Su-Feher, Iva Zdilar, Sarah Morse, Timothy A. Fenton, Anh Nguyen, Diana Quintero, Samrawit Agezew, Michael Sramek, Ellie J. Kreun, Jasmine Carter, Andrea Gompers, Jason T. Lambert, Cesar P. Canales, Len A. Pennacchio, Axel Visel, Diane E. Dickel, Jill L. Silverman, Alex S. Nord
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
Abstract Background Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the NaV1.1 sodium channel alpha su
Externí odkaz:
https://doaj.org/article/78fe0a2d5b104a109781adedaf6df4e5
Autor:
A. Ayanna Wade, Jelle van den Ameele, Seth W. Cheetham, Rebecca Yakob, Andrea H. Brand, Alex S. Nord
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103234- (2021)
Summary: Genetic studies of autism have revealed causal roles for chromatin remodeling gene mutations. Chromodomain helicase DNA binding protein 8 (CHD8) encodes a chromatin remodeler with significant de novo mutation rates in sporadic autism. Howeve
Externí odkaz:
https://doaj.org/article/4d31afdb8ce6460180b433cbe96604ab
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2019)
The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeli
Externí odkaz:
https://doaj.org/article/4b3524849b56475b971b7cf918ee7b55
Autor:
Jasmine L Carter, Axel Visel, Jason T Lambert, Andrea Gompers, Anh P Nguyen, Jill L. Silverman, Diana Quintero, Ellie J Kreun, Iva Zdilar, Nycole A. Copping, Cesar P Canales, Rinaldo Catta-Preta, Linda Su-Feher, Alexander Nord, Diane E. Dickel, Michael Sramek, Len A. Pennacchio, Anna Adhikari, Timothy A. Fenton, Tyler W. Stradleigh, A. Ayanna Wade, Sarah J Morse, Jessica L Haigh, Samrawit Agezew
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
Genome medicine, vol 13, iss 1
Genome Medicine
Genome medicine, vol 13, iss 1
Genome Medicine
BackgroundGenes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements.SCN1A,which encodes the NaV1.1 sodium channel alpha subunit, is on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcc81e446bcbf2264e54f3895f6d0ac
https://doaj.org/article/78fe0a2d5b104a109781adedaf6df4e5
https://doaj.org/article/78fe0a2d5b104a109781adedaf6df4e5
Autor:
Andrea H. Brand, Seth W. Cheetham, Jelle van den Ameele, A. Ayanna Wade, Rebecca Yakob, Alexander Nord
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103234-(2021)
iScience, Vol 24, Iss 11, Pp 103234-(2021)
Summary Genetic studies of autism have revealed causal roles for chromatin remodeling gene mutations. Chromodomain helicase DNA binding protein 8 (CHD8) encodes a chromatin remodeler with significant de novo mutation rates in sporadic autism. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58771e9dc36cdfdfad9c5856db6a3b83
http://europepmc.org/articles/PMC8551073
http://europepmc.org/articles/PMC8551073
Autor:
Alexandria Ayanna Wade, Lily R. Qiu, Jason P. Lerch, Adrienne Kinman, Zsuzsa Lindenmaier, Stela P. Petkova, Amie Creighton, Anna Adhikari, Alexander Nord, Jill L. Silverman, Jacob Ellegood, Lauryl M. J. Nutter, Darren J. Fernandes
Publikováno v:
Molecular autism, vol 12, iss 1
Molecular Autism, Vol 12, Iss 1, Pp 1-24 (2021)
Molecular Autism
Molecular Autism, Vol 12, Iss 1, Pp 1-24 (2021)
Molecular Autism
Background One of the causal mechanisms underlying neurodevelopmental disorders (NDDs) is chromatin modification and the genes that regulate chromatin. AT-rich interactive domain 1B (ARID1B), a chromatin modifier, has been linked to autism spectrum d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8bba7b6b8606225e246796b0c93561
https://escholarship.org/uc/item/68x6d2wx
https://escholarship.org/uc/item/68x6d2wx
Autor:
Rebecca Yakob, Seth W. Cheetham, A. Ayanna Wade, Jelle van den Ameele, Andrea H. Brand, Alexander Nord
Genetic studies of autism spectrum disorder (ASD) have revealed a causal role for mutations in chromatin remodeling genes. Chromodomain helicase DNA binding protein 8 (CHD8) encodes a chromatin remodeler with one of the highest de novo mutation rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e000c310d7aae43a0499a8739c54489
https://doi.org/10.1101/2021.01.12.426468
https://doi.org/10.1101/2021.01.12.426468
Autor:
Haigh, Jessica L., Adhikari, Anna, Nycole A. Copping, Stradleigh, Tyler, A. Ayanna Wade, Catta-Preta, Rinaldo, Su-Feher, Linda, Zdilar, Iva, Morse, Sarah, Fenton, Timothy A., Nguyen, Anh, Quintero, Diana, Samrawit Agezew, Sramek, Michael, Kreun, Ellie J., Carter, Jasmine, Gompers, Andrea, Lambert, Jason T., Canales, Cesar P., Pennacchio, Len A., Visel, Axel, Dickel, Diane E., Silverman, Jill L., Nord, Alex S.
Additional file 1: Supplementary Figures. Figure S1. Tissue and brain regional differences in chromatin conformation. Figure S2. Western blots of NaV1.1 (250 kDa) and β-actin (45 kDa) proteins in P29–32 brain lysates, membrane and cytoplasmic frac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb4bb9890f06c47289be5dc078bb1f4
Autor:
Haigh, Jessica L., Adhikari, Anna, Nycole A. Copping, Stradleigh, Tyler, A. Ayanna Wade, Catta-Preta, Rinaldo, Su-Feher, Linda, Zdilar, Iva, Morse, Sarah, Fenton, Timothy A., Nguyen, Anh, Quintero, Diana, Samrawit Agezew, Sramek, Michael, Kreun, Ellie J., Carter, Jasmine, Gompers, Andrea, Lambert, Jason T., Canales, Cesar P., Pennacchio, Len A., Visel, Axel, Dickel, Diane E., Silverman, Jill L., Nord, Alex S.
Additional file 3:. Table S2. Summary of measures of general health and development in wildtype, heterozygous and homozygous 1b deletion mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24070c44c780e2f9e9903b268f3d918b
Autor:
Haigh, Jessica L., Adhikari, Anna, Nycole A. Copping, Stradleigh, Tyler, A. Ayanna Wade, Catta-Preta, Rinaldo, Su-Feher, Linda, Zdilar, Iva, Morse, Sarah, Fenton, Timothy A., Nguyen, Anh, Quintero, Diana, Samrawit Agezew, Sramek, Michael, Kreun, Ellie J., Carter, Jasmine, Gompers, Andrea, Lambert, Jason T., Canales, Cesar P., Pennacchio, Len A., Visel, Axel, Dickel, Diane E., Silverman, Jill L., Nord, Alex S.
Additional file 4:. Table S3. Summary of the battery of behavioral tests.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6283703a01cec00b946f77c0393436ca