Zobrazeno 1 - 10
of 310
pro vyhledávání: '"A. Asipu"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Reactive oxygen species (ROS) serve vital physiological functions, but aberrant ROS production contributes to numerous diseases. Unfortunately, therapeutic progress targeting pathogenic ROS has been hindered by the limited understanding of w
Externí odkaz:
https://doaj.org/article/c4d3825191aa4b0891db0cea030e69b4
Akademický článek
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Publikováno v:
Scientific Reports; 8/8/2024, Vol. 14 Issue 1, p1-16, 16p
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysos
Externí odkaz:
https://doaj.org/article/120e8cecd5d341ada03f2a4a2713021f
Autor:
Christine P Diggle, Isabel Martinez-Garay, Zoltan Molnar, Martin H Brinkworth, Ed White, Ewan Fowler, Ruth Hughes, Bruce E Hayward, Ian M Carr, Christopher M Watson, Laura Crinnion, Aruna Asipu, Ben Woodman, P Louise Coletta, Alexander F Markham, T Neil Dear, David T Bonthron, Michelle Peckham, Ewan E Morrison, Eamonn Sheridan
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174264 (2017)
Tubulin alpha 8 (Tuba8) is the most divergent member of the highly conserved alpha tubulin family, and uniquely lacks two key post-translational modification sites. It is abundantly expressed in testis and muscle, with lower levels in the brain. We p
Externí odkaz:
https://doaj.org/article/018e0d0b0c5f4a439d4efb23ef2dfb63
Autor:
Helen M. Jopling, Adam F. Odell, Caroline Pellet-Many, Antony M. Latham, Paul Frankel, Asipu Sivaprasadarao, John H. Walker, Ian C. Zachary, Sreenivasan Ponnambalam
Publikováno v:
Cells, Vol 3, Iss 2, Pp 363-385 (2014)
Rab GTPases are implicated in endosome-to-plasma membrane recycling, but how such membrane traffic regulators control vascular endothelial growth factor receptor 2 (VEGFR2/KDR) dynamics and function are not well understood. Here, we evaluated two dif
Externí odkaz:
https://doaj.org/article/d502ac05087e41d3906980bd9115feaa
Autor:
Ishimoto, Takuji, Lanaspa, Miguel A., Le, MyPhuong T., Garcia, Gabriela E., Diggle, Christine P., MacLean, Paul S., Jackman, Matthew R., Asipu, Aruna, Roncal-Jimenez, Carlos A., Kosugi, Tomoki, Rivard, Christopher J., Maruyama, Shoichi, Rodriguez-Iturbe, Bernardo, Sánchez-Lozada, Laura G., Bonthron, David T., Sautin, Yuri Y., Johnson, Richard J.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2012 Mar . 109(11), 4320-4325.
Externí odkaz:
https://www.jstor.org/stable/41507140
Autor:
James A. Duce, Asipu Sivaprasadarao, Ellis Patrick, Andrew N. McCorkindale, Boris Guennewig, Andrew Tsatsanis, Robert W. Evans, Greg T. Sutherland, Bruce X. Wong, Ashley I. Bush, Timothy M. Ryan
Publikováno v:
Molecular Psychiatry
Amyloidogenic processing of the amyloid precursor protein (APP) forms the amyloid-β peptide (Aβ) component of pathognomonic extracellular plaques of AD. Additional early cortical changes in AD include neuroinflammation and elevated iron levels. Act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a332cc2f1c5b0b7b84ecee34c03f5d0
Akademický článek
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Autor:
Rucha Karnik, Melanie J Ludlow, Nada Abuarab, Andrew J Smith, Matthew E L Hardy, David J S Elliott, Asipu Sivaprasadarao
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85630 (2013)
The hERG potassium channel is critical for repolarisation of the cardiac action potential. Reduced expression of hERG at the plasma membrane, whether caused by hereditary mutations or drugs, results in long QT syndrome and increases the risk of ventr
Externí odkaz:
https://doaj.org/article/4b098201bb4e49979d0c500ef772d6d1