Isotropy of cosmic rays beyond $10^{20}$ eV favors their heavy mass composition

Autor: Telescope Array Collaboration, Abbasi, R. U., Abe, Y., Abu-Zayyad, T., Allen, M., Arai, Y., Arimura, R., Barcikowski, E., Belz, J. W., Bergman, D. R., Blake, S. A., Buckland, I., Cheon, B. G., Chikawa, M., Fujii, T., Fujisue, K., Fujita, K., Fujiwara, R., Fukushima, M., Furlich, G., Globus, N., Gonzalez, R., Hanlon, W., Hayashida, N., He, H., Hibi, R., Hibino, K., Higuchi, R., Honda, K., Ikeda, D., Inoue, N., Ishii, T., Ito, H., Ivanov, D., Iwasaki, A., Jeong, H. M., Jeong, S., Jui, C. C. H., Kadota, K., Kakimoto, F., Kalashev, O., Kasahara, K., Kasami, S., Kawakami, S., Kawata, K., Kharuk, I., Kido, E., Kim, H. B., Kim, J. H., Kim, S. W., Kimura, Y., Komae, I., Kuzmin, V., Kuznetsov, M., Kwon, Y. J., Lee, K. H., Lubsandorzhiev, B., Lundquist, J. P., Matsumiya, H., Matsuyama, T., Matthews, J. N., Mayta, R., Mizuno, K., Murakami, M., Myers, I., Nagataki, S., Nakai, K., Nakamura, T., Nishio, E., Nonaka, T., Oda, H., Ogio, S., Onishi, M., Ohoka, H., Okazaki, N., Oku, Y., Okuda, T., Omura, Y., Ono, M., Oshima, A., Oshima, H., Ozawa, S., Park, I. H., Park, K. Y., Potts, M., Pshirkov, M. S., Remington, J., Rodriguez, D. C., Rott, C., Rubtsov, G. I., Ryu, D., Sagawa, H., Saito, R., Sakaki, N., Sako, T., Sakurai, N., Sato, D., Sato, K., Sato, S., Sekino, K., Shah, P. D., Shibata, N., Shibata, T., Shikita, J., Shimodaira, H., Shin, B. K., Shin, H. S., Shinto, D., Smith, J. D., Sokolsky, P., Stokes, B. T., Stroman, T. A., Takagi, Y., Takahashi, K., Takamura, M., Takeda, M., Takeishi, R., Taketa, A., Takita, M., Tameda, Y., Tanaka, K., Tanaka, M., Tanoue, Y., Thomas, S. B., Thomson, G. B., Tinyakov, P., Tkachev, I., Tokuno, H., Tomida, T., Troitsky, S., Tsuda, R., Tsunesada, Y., Udo, S., Urban, F., Warren, D., Wong, T., Yamazaki, K., Yashiro, K., Yoshida, F., Zhezher, Y., Zundel, Z.

We report an estimation of the injected mass composition of ultra-high energy cosmic rays (UHECRs) at energies higher than 10 EeV. The composition is inferred from an energy-dependent sky distribution of UHECR events observed by the Telescope Array s

Externí odkaz: http://arxiv.org/abs/2406.19287

Finding Diverse Strings and Longest Common Subsequences in a Graph

Autor: Shida, Yuto, Punzi, Giulia, Kobayashi, Yasuaki, Uno, Takeaki, Arimura, Hiroki

In this paper, we study for the first time the Diverse Longest Common Subsequences (LCSs) problem under Hamming distance. Given a set of a constant number of input strings, the problem asks to decide if there exists some subset $\mathcal X$ of $K$ lo

Externí odkaz: http://arxiv.org/abs/2405.00131

A novel amphiphilic squalene-based compound with open-chain polyethers reduces malignant melanoma metastasis in-vitro and in-vivo

Autor: Yaman Zhang, Meriem Bejaoui, Tran Ngoc Linh, Takashi Arimura, Hiroko Isoda

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)

Abstract Squalene (SQ) is a well-known antioxidant and anti-inflammatory agent that provides promising anti-aging and UV-protective roles on human skin. However, its strong hydrophobic nature, accompanied by issues such as poor solubility and limited

Externí odkaz: https://doaj.org/article/22692d726e184fdbbc94b0f51b85c737

Minimum Consistent Subset for Trees Revisited

Autor: Arimura, Hiroki, Gima, Tatsuya, Kobayashi, Yasuaki, Nochide, Hiroomi, Otachi, Yota

In a vertex-colored graph $G = (V, E)$, a subset $S \subseteq V$ is said to be consistent if every vertex has a nearest neighbor in $S$ with the same color. The problem of computing a minimum cardinality consistent subset of a graph is known to be NP

Externí odkaz: http://arxiv.org/abs/2305.07259

Safety, pharmacokinetics, and pharmacodynamics of sofnobrutinib, a novel non‐covalent BTK inhibitor, in healthy subjects: First‐in‐human phase I study

Autor: Kyoko Miyamoto, Robert M. Miller, Christine Voors‐Pette, Jart A. F. Oosterhaven, Marieke van denDobbelsteen, Katsuhiro Mihara, Marian Geldof, Yuji Sato, Naomi Matsuda, Shirou Kirita, Masaaki Sawa, Akinori Arimura

Publikováno v: Clinical and Translational Science, Vol 17, Iss 11, Pp n/a-n/a (2024)

Abstract Bruton's tyrosine kinase (BTK) is a potential therapeutic target for allergic and autoimmune diseases. This first‐in‐human phase I study evaluated safety, pharmacokinetic, and pharmacodynamic profiles of sofnobrutinib (formerly AS‐0871

Externí odkaz: https://doaj.org/article/cbb99c7b7d034244b1d76a7bb8338933