Zobrazeno 1 - 10
of 3 893
pro vyhledávání: '"A. Almer"'
Autor:
Koziarski, Michał, Rekesh, Andrei, Shevchuk, Dmytro, van der Sloot, Almer, Gaiński, Piotr, Bengio, Yoshua, Liu, Cheng-Hao, Tyers, Mike, Batey, Robert A.
Generative models hold great promise for small molecule discovery, significantly increasing the size of search space compared to traditional in silico screening libraries. However, most existing machine learning methods for small molecule generation
Externí odkaz:
http://arxiv.org/abs/2406.08506
Autor:
Korablyov, Maksym, Liu, Cheng-Hao, Jain, Moksh, van der Sloot, Almer M., Jolicoeur, Eric, Ruediger, Edward, Nica, Andrei Cristian, Bengio, Emmanuel, Lapchevskyi, Kostiantyn, St-Cyr, Daniel, Schuetz, Doris Alexandra, Butoi, Victor Ion, Rector-Brooks, Jarrid, Blackburn, Simon, Feng, Leo, Nekoei, Hadi, Gottipati, SaiKrishna, Vijayan, Priyesh, Gupta, Prateek, Rampášek, Ladislav, Avancha, Sasikanth, Bacon, Pierre-Luc, Hamilton, William L., Paige, Brooks, Misra, Sanchit, Jastrzebski, Stanislaw Kamil, Kaul, Bharat, Precup, Doina, Hernández-Lobato, José Miguel, Segler, Marwin, Bronstein, Michael, Marinier, Anne, Tyers, Mike, Bengio, Yoshua
Despite substantial progress in machine learning for scientific discovery in recent years, truly de novo design of small molecules which exhibit a property of interest remains a significant challenge. We introduce LambdaZero, a generative active lear
Externí odkaz:
http://arxiv.org/abs/2405.01616
Autor:
Koziarski, Michał, Abukalam, Mohammed, Shah, Vedant, Vaillancourt, Louis, Schuetz, Doris Alexandra, Jain, Moksh, van der Sloot, Almer, Bourgey, Mathieu, Marinier, Anne, Bengio, Yoshua
DNA-encoded libraries (DELs) are a powerful approach for rapidly screening large numbers of diverse compounds. One of the key challenges in using DELs is library design, which involves choosing the building blocks that will be combinatorially combine
Externí odkaz:
http://arxiv.org/abs/2404.10094
Publikováno v:
Jurnal Medik Veteriner, Vol 7, Iss 2, Pp 382-387 (2024)
Fish productivity has long been the subject of studies using traditional Chinese medicine (TCM). To validate TCM's effectiveness on weight gain rate (WGR) and specific growth rate (SGR), a meta-analysis study was conducted. Of the 58 studies collecte
Externí odkaz:
https://doaj.org/article/fc7a58f4f1fe4aadb6fa22229b6c85db
Autor:
Dossou, Bonaventure F. P., Liu, Dianbo, Ji, Xu, Jain, Moksh, van der Sloot, Almer M., Palou, Roger, Tyers, Michael, Bengio, Yoshua
As antibiotic-resistant bacterial strains are rapidly spreading worldwide, infections caused by these strains are emerging as a global crisis causing the death of millions of people every year. Antimicrobial Peptides (AMPs) are one of the candidates
Externí odkaz:
http://arxiv.org/abs/2209.13518
Autor:
Ines A. Cadena, Gatha Adhikari, Alyssa Almer, Molly Jenne, Ndubuisi Obasi, Nicolas F. Soria Zurita, Willie E. Rochefort, Jenna L. Mueller, Kaitlin C. Fogg
Publikováno v:
Frontiers in Biomaterials Science, Vol 3 (2024)
Introduction: Cervical cancer, the second leading cause of cancer-related death for women worldwide, remains a preventable yet persistent disease that disproportionately affects women in low and middle-income countries (LMICs). While existing therapi
Externí odkaz:
https://doaj.org/article/3d8be3ee7b4646df8b5b58f08955fa26
Autor:
Bertin, Paul, Rector-Brooks, Jarrid, Sharma, Deepak, Gaudelet, Thomas, Anighoro, Andrew, Gross, Torsten, Martinez-Pena, Francisco, Tang, Eileen L., S, Suraj M, Regep, Cristian, Hayter, Jeremy, Korablyov, Maksym, Valiante, Nicholas, van der Sloot, Almer, Tyers, Mike, Roberts, Charles, Bronstein, Michael M., Lairson, Luke L., Taylor-King, Jake P., Bengio, Yoshua
For large libraries of small molecules, exhaustive combinatorial chemical screens become infeasible to perform when considering a range of disease models, assay conditions, and dose ranges. Deep learning models have achieved state of the art results
Externí odkaz:
http://arxiv.org/abs/2202.04202
Autor:
Tehlivets, Oksana, Almer, Gunter, Brunner, Markus S., Lechleitner, Margarete, Sommer, Gerhard, Kolb, Dagmar, Leitinger, Gerd, Diwoky, Clemens, Wolinski, Heimo, Habisch, Hansjörg, Opriessnig, Peter, Bogoni, Francesca, Pernitsch, Dominique, Kavertseva, Maria, Bourgeois, Benjamin, Kukilo, Jelena, Tehlivets, Yuriy G., Schwarz, Andreas N., Züllig, Thomas, Bubalo, Vladimir, Schauer, Silvia, Groselj-Strele, Andrea, Hoefler, Gerald, Rechberger, Gerald N., Herrmann, Markus, Eller, Kathrin, Rosenkranz, Alexander R., Madl, Tobias, Frank, Saša, Holzapfel, Gerhard A., Kratky, Dagmar, Mangge, Harald, Hörl, Gerd
Publikováno v:
In Biomedicine & Pharmacotherapy September 2024 178
Autor:
Figueroa Bengoa, Alejandro, Thomas, Jonova, Hunter, James, Kenesei, Peter, Miller, Brandon D., Almer, Jonathan, Okuniewski, Maria A.
Publikováno v:
In Journal of Nuclear Materials 15 August 2024 597
Autor:
Jan Söderman, Sven Almer
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 5, Pp 618-633 (2024)
Background and Aims: Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic inflammatory bowel diseases (IBDs) with an incompletely understood etiology and pathogenesis. Identification of suitable drug targets and assessment of disease severi
Externí odkaz:
https://doaj.org/article/9b9ce1964b604824acf7e6882c6a1e84