Zobrazeno 1 - 10
of 58
pro vyhledávání: '"A. Aladinskaya"'
Autor:
Yan A. Ivanenkov, Alex Zhavoronkov, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Andrey A. Ayginin, Victor G. Kartsev, Dmitry A. Skvortsov, Alexey V. Chemeris, Alexey Kh. Baimiev, Alina A. Sofronova, Alexander S. Malyshev, Gleb I. Filkov, Dmitry S. Bezrukov, Bogdan A. Zagribelnyy, Evgeny O. Putin, Maria M. Puchinina, Olga A. Dontsova
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Many pharmaceutical companies are avoiding the development of novel antibacterials due to a range of rational reasons and the high risk of failure. However, there is an urgent need for novel antibiotics especially against resistant bacterial strains.
Externí odkaz:
https://doaj.org/article/8c16a1d4d0ea467faf6fd76819573bdc
Autor:
Vladimir A. Aladinskiy, Rostislav A Petrov, Yan A. Ivanenkov, Mark S. Veselov, Andrey A Ayginin, Alexey Kh Baimiev, Maria M Puchinina, Marina A Maximova, Anastasia V. Aladinskaya, Dmitry A. Skvortsov, Kseniya Yu Shvetc, Yulia V. Vakhitova, Alina A. Sofronova, Ilya A. Osterman, Andrey Kh Baimiev, Zulfiya R Zileeva, Katerina S Komarova, Dmitry S. Bezrukov, L. F. Zainullina, Victor A Terentiev, Bogdan A Zagribelnyy, Petr V. Sergiev, Alexey E. Machulkin, Renat S. Yamidanov, Olga A. Dontsova
Publikováno v:
Current Drug Discovery Technologies. 17:716-724
Background: The key issue in the development of novel antimicrobials is a rapid expansion of new bacterial strains resistant to current antibiotics. Indeed, World Health Organization has reported that bacteria commonly causing infections in hospitals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a9cc3c7142a75575f2c9fc022e9cc1
https://doi.org/10.2174/1570163816666190603095521
https://doi.org/10.2174/1570163816666190603095521
Autor:
Rostislav A Petrov, Dmitry A. Skvortsov, Yulia V. Vakhitova, L. F. Zainullina, Andrey A Ayginin, Yan A. Ivanenkov, Marina A Maximova, Mark S. Veselov, Alina A. Sofronova, Petr V. Sergiev, G. I. Filkov, Alexey E. Machulkin, Katerina S Komarova, Anastasia V. Aladinskaya, Renat S. Yamidanov, Victor A Terentiev, Olga A. Dontsova, Alexander S. Malyshev, Alexey Kh Baimiev, Maria M Puchinina, Ilya A. Osterman, Dmitry S. Bezrukov, A. V. Chemeris, Zulfiya R Zileeva, Vladimir A. Aladinskiy
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 22:346-354
Aim and Objective:Antibiotic resistance is a serious constraint to the development of new effective antibacterials. Therefore, the discovery of the new antibacterials remains one of the main challenges in modern medicinal chemistry. This study was un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336c3c036716b074c805801cbd19401f
https://doi.org/10.2174/1386207322666190412165316
https://doi.org/10.2174/1386207322666190412165316
Autor:
Andrey Baymiev, Rostislav A Petrov, Svetlana Iu Iarovenko, Vladimir A. Aladinskiy, Renat S. Yamidanov, Alexey E. Machulkin, Yan A. Ivanenkov, Mark S. Veselov, Katerina S Komarova, Olga A. Dontsova, Alexander S. Malyshev, Anastasia V. Aladinskaya, Victor A Terentiev, Andrey A Ayginin, Alina A. Sofronova, Petr V. Sergiev, Dmitry A. Skvortsov, Sergey V. Sadovnikov, Dmitrii A. Lukianov, Ilya A. Osterman, Dmitry S. Bezrukov, R.T. Matniyazov
Publikováno v:
The Journal of Antibiotics. 72:827-833
The present report describes our efforts to identify new structural classes of compounds having promising antibacterial activity using previously published double-reporter system pDualrep2. This semi-automated high-throughput screening (HTS) platform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a36fba2b0d31d2a9e5211cc1d0ef53e
https://doi.org/10.1038/s41429-019-0211-y
https://doi.org/10.1038/s41429-019-0211-y
Autor:
Nikolay V. Zyk, Irina V. Saltykova, Anastasiya V Aladinskaya, Alexander Erofeev, Olga O. Krasnovskaya, Radik R. Shafikov, Elena K. Beloglazkina, Anastasiia S Garanina, Oleg Yu. Saveliev, Maxim A. Abakumov, Vladimir I. Polshakov, Ekaterina A. Nimenko, Yan A. Ivanenkov, Aleksei E. Machulkin, Olga A. Dontsova, Emil U Yamansarov, Alexander G. Majouga, Elena S. Khazanova, Anastasia A. Uspenskaya, Anton P. Ber, Galina B. Smirnova, Vadim S. Pokrovsky, Nikolay U. Zyk, Dmitry A. Skvortsov, Petr V. Gorelkin, Stanislav A. Petrov, A. V. Finko, Rauf T Akhmirov
Publikováno v:
Journal of medicinal chemistry. 64(8)
Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is a suitable target for specific delivery of antitumor drugs and diagnostic agents due to its overexpression in prostate cancer cells. In the current wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2bdb39740f4dc14b677c9a847824bf
https://pubmed.ncbi.nlm.nih.gov/33822606
https://pubmed.ncbi.nlm.nih.gov/33822606
Autor:
Alexander N. Orekhov, Gleb A. Korobov, Yuri V. Bobryshev, Igor A. Sobenin, Nikita G. Nikiforov, Natalia V. Elizova, Anastasia V. Aladinskaya
Publikováno v:
Current Pharmaceutical Design. 24:2883-2889
Atherosclerosis is regarded as a chronic inflammatory disease associated with changes in the innate immune system functioning and cytokine disturbances. Local inflammation in the arterial wall is an important component in the development and growth o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02d7f922f3e5d8c8f3b85dccdebe1fa6
https://doi.org/10.2174/1381612824666180911120726
https://doi.org/10.2174/1381612824666180911120726
Autor:
Alex Zhavoronkov, Alexander Aliper, Yan A. Ivanenkov, Arip Asadulaev, Anastasia V. Aladinskaya, Quentin Vanhaelen, Evgeny Putin
Publikováno v:
Molecular Pharmaceutics. 15:4386-4397
In this article, we propose the deep neural network Adversarial Threshold Neural Computer (ATNC). The ATNC model is intended for the de novo design of novel small-molecule organic structures. The model is based on generative adversarial network archi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03233f2232b5383bdc6789cec6b18844
https://doi.org/10.1021/acs.molpharmaceut.7b01137
https://doi.org/10.1021/acs.molpharmaceut.7b01137
Autor:
Yan A. Ivanenkov, Alex Zhavoronkov, Mark S. Veselov, Rim Shayakhmetov, Anastasiya V Aladinskaya, Daniil Polykovskiy, Victor A Terentiev, Vladimir A. Aladinskiy, Bogdan A Zagribelnyy, Tao Guo, Artem Zholus, Yury Volkov, Alexander Zhebrak, Lennart H Lee, Li Xing, Lidiya I Minaeva, Richard Soll, Alán Aspuru-Guzik, Alexander Aliper, David Madge, Maksim Kuznetsov, Arip Asadulaev
Publikováno v:
Nature Biotechnology. 37:1038-1040
We have developed a deep generative model, generative tensorial reinforcement learning (GENTRL), for de novo small-molecule design. GENTRL optimizes synthetic feasibility, novelty, and biological activity. We used GENTRL to discover potent inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57935a11c69db73ee57db030f1e4ba3b
https://doi.org/10.1038/s41587-019-0224-x
https://doi.org/10.1038/s41587-019-0224-x
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Autor:
Machulkin, Alexey E., Skvortsov, Dmitry A., Ivanenkov, Yan A., Ber, Anton P., Kavalchuk, Mikhail V., Aladinskaya, Anastasia V., Uspenskaya, Anastasia A., Shafikov, Radik R., Plotnikova, Ekaterina A., Yakubovskaya, Raisa I., Nimenko, Ekaterina A., Zyk, Nikolay U., Beloglazkina, Elena K., Zyk, Nikolay V., Koteliansky, Victor E, Majouga, Alexander G.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 August 2019 29(16):2229-2235