Zobrazeno 1 - 10
of 17
pro vyhledávání: '"A. Akhiad Bercovich"'
Autor:
N. Zioni, A. Akhiad Bercovich, N. Chapal-Ilani, Tal Bacharach, N. Rappoport, A. Solomon, R. Avraham, E. Kopitman, Z. Porat, M. Sacma, G. Hartmut, M. Scheller, C. Muller-Tidow, D. Lipka, E. Shlush, M. Minden, N. Kaushansky, Liran I. Shlush
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Both fatty bone marrow (FBM) and somatic mutations in hematopoietic stem cells (HSCs), also termed clonal hematopoiesis (CH) accumulate with human aging. However it remains unclear whether FBM can modify the evolution of CH. To address this
Externí odkaz:
https://doaj.org/article/9630880f8f224249bf53ebc74fbd8b46
Autor:
Tzah Feldman, Akhiad Bercovich, Yoni Moskovitz, Noa Chapal-Ilani, Amanda Mitchell, Jessie J. F. Medeiros, Tamir Biezuner, Nathali Kaushansky, Mark D. Minden, Vikas Gupta, Michael Milyavsky, Zvi Livneh, Amos Tanay, Liran I. Shlush
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The mutational mechanisms that produce insertions and deletions that lead to clonal hematopoiesis are poorly understood. Here the authors show evidence that frequent deletions that are relevant to myeloid malignancies could be produced by PARP1-depen
Externí odkaz:
https://doaj.org/article/5cd49203803b4c6e921be0f40f64c457
Autor:
Yael Baran, Akhiad Bercovich, Arnau Sebe-Pedros, Yaniv Lubling, Amir Giladi, Elad Chomsky, Zohar Meir, Michael Hoichman, Aviezer Lifshitz, Amos Tanay
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract scRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique cell that can never be resampled, and robust analysis must separate the sampling effect from biological variance. We describe a methodology for partiti
Externí odkaz:
https://doaj.org/article/9753d7773ac942dbb045658e3b7d0981
We describe MCProj - an algorithm for analyzing query scRNA-seq data by projections over reference single cell atlases. We represent the reference as a manifold consisting of annotated metacell gene expression distributions. We then infer query metac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b283723bbf067f3b81f09e8d382aea
https://doi.org/10.1101/2022.12.01.518678
https://doi.org/10.1101/2022.12.01.518678
Autor:
Amos Tanay, Zvi Livneh, Vikas Gupta, Mark D. Minden, Jessie J. F. Medeiros, Nathali Kaushansky, Liran I. Shlush, Tzah Feldman, Amanda Mitchell, Michael Milyavsky, Yoni Moskovitz, Tamir Biezuner, Noa Chapal-Ilani, Akhiad Bercovich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
The mutational mechanisms underlying recurrent deletions in clonal hematopoiesis are not entirely clear. In the current study we inspect the genomic regions around recurrent deletions in myeloid malignancies, and identify microhomology-based signatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584d2822f7612580ca0d4036323b9ce2
https://doaj.org/article/5cd49203803b4c6e921be0f40f64c457
https://doaj.org/article/5cd49203803b4c6e921be0f40f64c457
Autor:
Sander I. van Kasteren, Luuk Reinalda, Eyal David, Hanjie Li, Linda Y. Y. Chen, Anne van der Leun, Amos Tanay, Ido Amit, Mireille Toebes, Ton N. Schumacher, Akhiad Bercovich, Yaniv Lubling, Mirjam E. Hoekstra, Colinda L.G.J. Scheele, Jacco van Rheenen, Daniela S. Thommen, Michel J. van de Graaff
Publikováno v:
Nature Chemical Biology
Nature Chemical Biology, 17, 1139-1147
Nature Chemical Biology, 17, 1139-1147
The functional activity and differentiation potential of cells are determined by their interactions with surrounding cells. Approaches that allow unbiased characterization of cell states while at the same time providing spatial information are of maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f05bfda6555a45061a841f6c33d6ae7
https://hdl.handle.net/1887/3242834
https://hdl.handle.net/1887/3242834
Publikováno v:
Genome Biology
Scaling scRNA-seq to profile millions of cells is crucial for constructing high-resolution maps of transcriptional manifolds. Current analysis strategies, in particular dimensionality reduction and two-phase clustering, offer only limited scaling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ce47021b674cb22fbe9935c03e7976
https://pubmed.ncbi.nlm.nih.gov/35440087
https://pubmed.ncbi.nlm.nih.gov/35440087
Autor:
Anne van der Leun, Mirjam Hoekstra, Luuk Reinalda, Colinda Scheele, Mireille Toebes, Michel van de Graaff, Hanjie Li, Akhiad Bercovich, Yaniv Lubling, Eyal David, Daniela Thommen, Amos Tanay, Jacco van Rheenen, Ido Amit, Sander van Kasteren, Ton Schumacher
The functional activity and differentiation potential of cells is determined by their interaction with surrounding cells. Approaches that allow the unbiased characterization of cell states while at the same time providing spatial information are of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90934c0ff5ec70f6a1d2d54c6f3daffb
https://doi.org/10.1101/2020.10.02.291096
https://doi.org/10.1101/2020.10.02.291096
Autor:
Liran I. Shlush, Vikas Gupta, Nathali Kaushansky, Tzah Feldman, Amos Tanay, Noa Chapal-Ilani, Jessie J. F. Medeiros, Mark D. Minden, Yoni Moskovitz, Amanda Mitchell, Akhiad Bercovich, Tamir Biezuner
The mechanisms underlying myeloid malignancies deletions are not well understood, nor is it clear why specific genomic hotspots are predisposed to particular deletions. In the current study we inspected the genomic regions around recurrent deletions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cefb8239786268911ddda0058526edf
Autor:
Amir Giladi, Akhiad Bercovich, Michael Hoichman, Aviezer Lifshitz, Elad Chomsky, Yaniv Lubling, Zohar Meir, Amos Tanay, Arnau Sebé-Pedrós, Yael Baran
Publikováno v:
Genome Biology
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
scRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique cell that can never be resampled, and robust analysis must separate the sampling effect from biological variance. We describe a methodology for partitioning scR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772942b3c9301128e27c53769ac599f1
http://europepmc.org/articles/PMC6790056
http://europepmc.org/articles/PMC6790056