Zobrazeno 1 - 10
of 6 400
pro vyhledávání: '"A. Aguzzi"'
Autor:
A. Matamoros-Angles, A. Hervera, J. Soriano, E. Martí, P. Carulla, F. Llorens, M. Nuvolone, A. Aguzzi, I. Ferrer, A. Gruart, J. M. Delgado-García, J. A. Del Río
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-25 (2022)
Abstract Background Cellular prion protein (PrPC) is a cell surface GPI-anchored protein, usually known for its role in the pathogenesis of human and animal prionopathies. However, increasing knowledge about the participation of PrPC in prion pathoge
Externí odkaz:
https://doaj.org/article/3fb7c618f11c42a0a6a16834ddcd6437
In recent advancements in machine learning, federated learning allows a network of distributed clients to collaboratively develop a global model without needing to share their local data. This technique aims to safeguard privacy, countering the vulne
Externí odkaz:
http://arxiv.org/abs/2407.12410
Autor:
Casadei, Roberto, Aguzzi, Gianluca, Audrito, Giorgio, Damiani, Ferruccio, Pianini, Danilo, Scarso, Giordano, Torta, Gianluca, Viroli, Mirko
Today's distributed and pervasive computing addresses large-scale cyber-physical ecosystems, characterised by dense and large networks of devices capable of computation, communication and interaction with the environment and people. While most resear
Externí odkaz:
http://arxiv.org/abs/2406.04780
Swarm behaviour engineering is an area of research that seeks to investigate methods and techniques for coordinating computation and action within groups of simple agents to achieve complex global goals like pattern formation, collective movement, cl
Externí odkaz:
http://arxiv.org/abs/2401.10969
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2
Autor:
Kathi Ging, Lukas Frick, Johannes Schlachetzki, Andrea Armani, Yanping Zhu, Pierre-André Gilormini, Ashutosh Dhingra, Desirée Böck, Ana Marques, Matthew Deen, Xi Chen, Tetiana Serdiuk, Chiara Trevisan, Stefano Sellitto, Claudio Pisano, Christopher K. Glass, Peter Heutink, Jiang-An Yin, David J. Vocadlo, Adriano Aguzzi
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-18 (2024)
Abstract Mutations in GBA1 encoding the lysosomal enzyme β-glucocerebrosidase (GCase) are among the most prevalent genetic susceptibility factors for Parkinson’s disease (PD), with 10–30% of carriers developing the disease. To identify genetic m
Externí odkaz:
https://doaj.org/article/4c0ae1d7d594437b8f6bf9199fd5b7f6
Autor:
Julia Sala-Jarque, Vanessa Gil, Pol Andrés-Benito, Inés Martínez-Soria, Pol Picón-Pagès, Félix Hernández, Jesús Ávila, José Luis Lanciego, Mario Nuvolone, Adriano Aguzzi, Rosalina Gavín, Isidro Ferrer, José Antonio del Río
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The cellular prion protein (PrPC) plays many roles in the developing and adult brain. In addition, PrPC binds to several amyloids in oligomeric and prefibrillar forms and may act as a putative receptor of abnormal misfolded protein species.
Externí odkaz:
https://doaj.org/article/2f78e00735454e27858d150cc64c59b9
Autor:
Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niklas Bargenda, Niels J Rupp, Manfredi C Carta, Karl J Frontzek, Veronika Lysenko, Regina R Reimann, Petra Schwarz, Mario Nuvolone, Gunilla T Westermark, K Peter R Nilsson, Magdalini Polymenidou, Alexandre PA Theocharides, Simone Hornemann, Paola Picotti, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2024-2042 (2024)
Abstract Extracellularly released molecular inflammasome assemblies -ASC specks- cross-seed Aβ amyloid in Alzheimer’s disease. Here we show that ASC governs the extent of inflammation-induced amyloid A (AA) amyloidosis, a systemic disease caused b
Externí odkaz:
https://doaj.org/article/361701b3ccf5457e8ccf997a37e06f01
Publikováno v:
International Journal of Sociology and Social Policy, 2024, Vol. 44, Issue 5/6, pp. 499-515.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/IJSSP-11-2023-0303
Autor:
Jacopo Aguzzi, Laurenz Thomsen, Sascha Flögel, Nathan J. Robinson, Giacomo Picardi, Damianos Chatzievangelou, Nixon Bahamon, Sergio Stefanni, Jordi Grinyó, Emanuela Fanelli, Cinzia Corinaldesi, Joaquin Del Rio Fernandez, Marcello Calisti, Furu Mienis, Elias Chatzidouros, Corrado Costa, Simona Violino, Michael Tangherlini, Roberto Danovaro
Publikováno v:
Engineering, Vol 34, Iss , Pp 195-211 (2024)
The United Nations (UN)’s call for a decade of “ecosystem restoration” was prompted by the need to address the extensive impact of anthropogenic activities on natural ecosystems. Marine ecosystem restoration is increasingly necessary due to inc
Externí odkaz:
https://doaj.org/article/c24b4b44dff842a194ea87c9a7afa78c
Autor:
Nikita Vladimirov, Fabian F. Voigt, Thomas Naert, Gabriela R. Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther Stoeckli, Laura Baudis, Soeren S. Lienkamp, Fritjof Helmchen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract In 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging larger samples at higher speed and resolution has increased, r
Externí odkaz:
https://doaj.org/article/4cf7c9c96dd44b30a9b9e21fc559f8fd