Zobrazeno 1 - 10
of 213
pro vyhledávání: '"A. A. Tykhomyrov"'
Publikováno v:
Biotechnologia Acta, Vol 14, Iss 3, Pp 30-38 (2021)
Current large-scale production of blood-derived pharmacological preparations is aimed at expanding the list of products and deeper extraction of target proteins especially at the pre-purification stage. In particular, this problem becomes critical fo
Externí odkaz:
https://doaj.org/article/cfd48b39de9c4282a4f422b2827f286b
Autor:
E. I. Yusova, T. V. Grinenko, T. O. Goncharenko, L. G. Kapustyanenko, A. A. Sobchenko, A. A. Tykhomyrov
Publikováno v:
Biotechnologia Acta, Vol 13, Iss 5, Pp 62-72 (2020)
Tissue plasminogen activator (tPA) is one of the key protein of plasminogen/plasmin system that converts plasminogen in the active proteinase plasmin. Platelets are able to bind both tPA and plasminogen on their surface, thus providing stimulatory ef
Externí odkaz:
https://doaj.org/article/cc31604b7bcb4d0faf00ec1bd79f11b8
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 3, Pp 46-57 (2020)
The interaction of the fifth kringle of Glu-plasminogen with fibrin triggers activation and initiation of fibrinolysis, yet the site on fibrin that binds kringle 5 remains unknown. The aim of our work was to determine an amino acid sequence in the D-
Externí odkaz:
https://doaj.org/article/879e8ae2101248918bd7d6cb4eae8ba5
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 1, Pp 31-40 (2020)
Platelets store, produce and release a variety of angiogenesis regulators, which can contribute to both normal tissue repair and angiopathy-associated pathologies. Plasminogen has been earlier shown to regulate some platelet functions, but if it is a
Externí odkaz:
https://doaj.org/article/fd349aa18c6e4f93a9e5b409b2a7f720
Publikováno v:
The Ukrainian Biochemical Journal, Vol 91, Iss 5, Pp 34-45 (2019)
Ischemic stroke is considered as one of the most frequent and severe complications of atrial fibrillation. The present study was undertaken to examine whether post-insult treatment with cytidine diphosphate-choline (CDP-choline, or citicoline) affect
Externí odkaz:
https://doaj.org/article/62d6adc33a694f6fb28ff76f41cf0927
Autor:
O. S. Pavlova, A. A. Tykhomyrov, O. A. Mejenskaya, S. P. Stepanenko, L. I. Chehivska, Yu. M. Parkhomenko
Publikováno v:
The Ukrainian Biochemical Journal, Vol 91, Iss 4, Pp 41-49 (2019)
Long-term ethyl alcohol consumption induces a deficiency of essential nutrient thiamine (vitamin B1 ) and profoundly impairs metabolic processes in nervous tissue, resulting in structural and functional alterations in the central nervous system (CNS)
Externí odkaz:
https://doaj.org/article/f0d533ed47464c9db43b00252a07634b
Autor:
O. M. Petrenko, A. A. Tykhomyrov
Publikováno v:
The Ukrainian Biochemical Journal, Vol 91, Iss 1, Pp 100-107 (2019)
Martorell hypertensive ischemic leg ulcers (HYTILU) represent a unique form of lower extremity non-healing ulcers that develop in association with poorly controlled high blood pressure. The present study was performed in order to assess levels of pro
Externí odkaz:
https://doaj.org/article/9d0280c5c53e489488d578045635ccf2
Publikováno v:
The Ukrainian Biochemical Journal, Vol 90, Iss 6, Pp 31-40 (2018)
Reactive oxygen species (ROS) are considered to be important signalling molecules controlling many platelet functions. ROS production has been shown to be augmented by platelet activation, however, plasminogen (Pg) has not been studied in the context
Externí odkaz:
https://doaj.org/article/50aabc5305584f07a9ccda8cd5a466ab
Publikováno v:
The Ukrainian Biochemical Journal, Vol 89, Iss 2, Pp 43-54 (2017)
The purpose of the present study was to examine the plasminogen localization and to detect levels of its fragments (angiostatins) in various regions of rat brain as well as to establish whether rat brain astrocytes could be involved in angiostatin pr
Externí odkaz:
https://doaj.org/article/3f0cfa3844094c2d86baecd4a2f78dd6
Publikováno v:
The Ukrainian Biochemical Journal, Vol 87, Iss 5, Pp 103-112 (2015)
It is known that benign breast tissue exhibit relatively low angiogenic capacity. Activation of angiogenesis in mammary pre-malignant lesions could be associated with disease progression and high risk of transformation into the breast cancer. However
Externí odkaz:
https://doaj.org/article/5699b353f80d4f2eb10407ec62aca9c0