Zobrazeno 1 - 10
of 1 377
pro vyhledávání: '"A. A. Kyba"'
Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma
Autor:
Erdong Wei, Ana Mitanoska, Quinn O’Brien, Kendall Porter, MacKenzie Molina, Haseeb Ahsan, Usuk Jung, Lauren Mills, Michael Kyba, Darko Bosnakovski
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-22 (2024)
Abstract Ewing sarcoma (ES) poses a significant therapeutic challenge due to the difficulty in targeting its main oncodriver, EWS::FLI1. We show that pharmacological targeting of the EWS::FLI1 transcriptional complex via inhibition of P300/CBP drives
Externí odkaz:
https://doaj.org/article/3923b7e698e143889b1d963ad608e92e
Autor:
Sgro, Lauren A., Esposito, Thomas M., Blaclard, Guillaume, Gomez, Sebastian, Marchis, Franck, Filippenko, Alexei V., Peluso, Daniel O'Conner, Lawrence, Stephen S., Verveen, Aad, Wagner, Andreas, Nardi, Anouchka, Wiart, Barbara, Mirwald, Benjamin, Christensen, Bill, Eramia, Bob, Parker, Bruce, Guillet, Bruno, Kim, Byungki, Logan, Chelsey A., Kyba, Christopher C. M., Toulmin, Christopher, Vantaggiato, Claudio G., Adhis, Dana, Gary, Dave, Goodey, Dave, Dickinson, David, Koster, David, Martin, Davy, Bonilla, Eliud, Chung, Enner, Miny, Eric, Mortecrette, Fabrice, Saibi, Fadi, Gagnon, Francois O., Simard, François, Vacon, Gary, Simard, Georges, Dreise, Gerrit, Funakoshi, Hiromi, Vacon, Janet, Yaniz, James, Tarnec, Jean-Charles Le, Laugier, Jean-Marie, Siders, Jennifer L. W., Sweitzer, Jim, Dvoracek, Jiri, Archer, John, Deitz, John, Bradley, John K., Fukui, Keiichi, Sibbernsen, Kendra, Borrot, Kevin, Cross, Kevin, Heider, Kevin, Yamaguchi, Koichi, Hirsch, Lea A., Leroux, Liouba, Billiani, Mario, Lorber, Markus, Smallen, Martin J., Shimizu, Masao, Nishimura, Masayoshi, Ryno, Matthew, Cunningham, Michael, Gagnon, Michael, Primm, Michael, Rushton, Michael, Sibbernsen, Michael, Mitchell, Mike, Yoblonsky, Neil, Leroux, Niniane, Clerget, Olivier, Stojanović, Ozren, Unique, Patrice, Huth, Patrick, Ang, Raymund John, Santoni, Regis, Foster, Robert, Poggiali, Roberto, Xu, Ruyi, Kukita, Ryuichi, Šćepanović, Sanja, Saibi, Sophie, Will, Stefan, Latour, Stephan, Haythornthwaite, Stephen, Cadieux, Sylvain, Müller, Thoralf, Chung, Tze Yang, Watanabe, Yoshiya, Arnaud, Yvan
Publikováno v:
Res. Notes AAS 7 141 (2023)
We present highly sampled photometry of the supernova (SN) 2023ixf, a Type II SN in M101, beginning 2 days before its first known detection. To gather these data, we enlisted the global Unistellar Network of citizen scientists. These 252 observations
Externí odkaz:
http://arxiv.org/abs/2307.14347
Autor:
Fikru B. Bedada, Brian R. Thompson, Jennifer L. Mikkila, Sunny S.-K. Chan, Si Ho Choi, Erik A. Toso, Michael Kyba, Joseph M. Metzger
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Human induced pluripotent stem cells and their differentiation into cardiac myocytes (hiPSC-CMs) provides a unique and valuable platform for studies of cardiac muscle structure–function. This includes studies centered on disease etiology,
Externí odkaz:
https://doaj.org/article/62a45a61bcc04174b4a0815bbbae4f4f
Autor:
Christine A. Schneider, Jacqueline M. Leung, Paola Carolina Valenzuela-Leon, Natalya A. Golviznina, Erik A. Toso, Darko Bosnakovski, Michael Kyba, Eric Calvo, Karin E. Peterson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The first step in disease pathogenesis for arboviruses is the establishment of infection following vector transmission. For La Crosse virus (LACV), the leading cause of pediatric arboviral encephalitis in North America, and other orthobunyav
Externí odkaz:
https://doaj.org/article/4a95caf36b46418ca720870f4fc936b0
Publikováno v:
Journal of Quantitative Spectroscopy and Radiative Transfer, 250, 106988 (2020)
Artificial skyglow is a form of light pollution with wide ranging implications on the environment. The extent, intensity and color of skyglow depends on the artificial light sources and weather conditions. Skyglow can be best determined with ground b
Externí odkaz:
http://arxiv.org/abs/2202.08258
Publikováno v:
Український журнал серцево-судинної хірургії, Vol 31, Iss 4, Pp 26-33 (2023)
The aim. To study the long-term results of stenting in patients with coronary artery disease with hemodynamically significant left main coronary artery (LMCA) stenoses. Materials and methods. The study included 67 patients (56 men, 11 women) with
Externí odkaz:
https://doaj.org/article/7a072317944c446a805f438b6fb0e211
Autor:
Isabela T. Pereira, Rubens Gomes-Júnior, Aruana Hansel-Frose, Rhaíza S. V. França, Man Liu, Hossam A. N. Soliman, Sunny S. K. Chan, Samuel C. Dudley, Michael Kyba, Bruno Dallagiovanna
Publikováno v:
Cells, Vol 13, Iss 12, p 1050 (2024)
Successful heart development depends on the careful orchestration of a network of transcription factors and signaling pathways. In recent years, in vitro cardiac differentiation using human pluripotent stem cells (hPSCs) has been used to uncover the
Externí odkaz:
https://doaj.org/article/ada258bcac3d4fd6990afcf91bd074ee
Autor:
Aharmim, B., Ahmed, S. N., Anthony, A. E., Barros, N., Beier, E. W., Bellerive, A., Beltran, B., Bergevin, M., Biller, S. D., Blucher, E., Bonventre, R., Boudjemline, K., Boulay, M. G., Cai, B., Callaghan, E. J., Caravaca, J., Chan, Y. D., Chauhan, D., Chen, M., Cleveland, B. T., Cox, G. A., Dai, X., Deng, H., Descamps, F. B., Detwiler, J. A., Doe, P. J., Doucas, G., Drouin, P. -L., Dunford, M., Elliott, S. R., Evans, H. C., Ewan, G. T., Farine, J., Fergani, H., Fleurot, F., Ford, R. J., Formaggio, J. A., Gagnon, N., Gilje, K., Goon, J. TM., Graham, K., Guillian, E., Habib, S., Hahn, R. L., Hallin, A. L., Hallman, E. D., Harvey, P. J., Hazama, R., Heintzelman, W. J., Heise, J., Helmer, R. L., Hime, A., Howard, C., Huang, M., Jagam, P., Jamieson, B., Jelley, N. A., Jerkins, M., Keeter, K. J., Klein, J. R., Kormos, L. L., Kos, M., Kraus, C., Krauss, C. B., Krüger, A., Kutter, T., Kyba, C. C. M., Labe, K., Land, B. J., Lange, R., LaTorre, A., Law, J., Lawson, I. T., Lesko, K. T., Leslie, J. R., Levine, I., Loach, J. C., MacLellan, R., Majerus, S., Mak, H. B., Maneira, J., Martin, R. D., Mastbaum, A., McCauley, N., McDonald, A. B., McGee, S. R., Miller, M. L., Monreal, B., Monroe, J., Nickel, B. G., Noble, A. J., O'Keeffe, H. M., Oblath, N. S., Okada, C. E., Ollerhead, R. W., Gann, G. D. Orebi, Oser, S. M., Ott, R. A., Peeters, S. J. M., Poon, A. W. P., Prior, G., Reitzner, S. D., Rielage, K., Robertson, B. C., Robertson, R. G. H., Schwendener, M. H., Secrest, J. A., Seibert, S. R., Simard, O., Sinclair, D., Skensved, P., Sonley, T. J., Stonehill, L. C., Tešić, G., Tolich, N., Tsui, T., Van Berg, R., VanDevender, B. A., Virtue, C. J., Wall, B. L., Waller, D., Tseung, H. Wan Chan, Wark, D. L., Wendland, J., West, N., Wilkerson, J. F., Wilson, J. R., Winchester, T., Wright, A., Yeh, M., Zhang, F., Zuber, K.
Publikováno v:
Phys. Rev. D 102, 062006 (2020)
A search has been performed for neutrinos from two sources, the $hep$ reaction in the solar $pp$ fusion chain and the $\nu_e$ component of the diffuse supernova neutrino background (DSNB), using the full dataset of the Sudbury Neutrino Observatory wi
Externí odkaz:
http://arxiv.org/abs/2007.08018
Autor:
Barentine, John C., Kundracik, František, Kocifaj, Miroslav, Sanders, Jessie C., Esquerdo, Gilbert A., Dalton, Adam M., Foott, Bettymaya, Grauer, Albert, Tucker, Scott, Kyba, Christopher C. M.
Anthropogenic skyglow dominates views of the natural night sky in most urban settings, and the associated emission of artificial light at night (ALAN) into the environment of cities involves a number of known and suspected negative externalities. One
Externí odkaz:
http://arxiv.org/abs/2005.12357
Autor:
Andrea Gokus, Andreas Hänel, Andreas Ruby, Arne Dröge-Rothaar, Brita Küchly, Christopher C. M. Kyba, Daniel Fischer, David Gruber, Eva C. Weiß, Friederike Klan, Georg Sulzer, Georgia T. MacMillan, Helga Küchly, Henning von Brandis, Isabell C. Wuthenow, Jacob Koglin, Janina Mattern, Johannes A. Schultz, Johannes Veh, Katharina Leiter, Marcus Langejahn, Maria Zschorn, Marijana Pavi´c, Maximilian Blaschke, Melanie Brauchler, Michaela Leipold, Nathalie Küppers, Nona Schulte-Römer, Normän Naboulsi, Petra Bilela, Reinhart Binder, René Curwy, Sabine Frank, Sebastian Falkner, Sicco Bauer, Steffen Liese, Swantje Maurer, Tamara Rom, Thomas Kunzemann, Vita Tičinović, Yiğit Öner Altıntaş, Loeka L. Jongejans
Publikováno v:
International Journal of Sustainable Lighting, Vol 25, Iss 1 (2023)
The relationship between satellite based measurements of city radiance at night and the numbers and types of physical lights installed on the ground is not well understood. Here we present the “Nachtlichter app”, which was developed to enable cit
Externí odkaz:
https://doaj.org/article/2a181713ae4e4d0b90e6af9a1a1f73d8