Zobrazeno 1 - 10
of 1 495
pro vyhledávání: '"A. A. J. van de Loo"'
Autor:
Onno J. Arntz, Rogier M. Thurlings, Esmeralda N. Blaney Davidson, Pascal W. T. C. Jansen, Michiel Vermeulen, Marije I. Koenders, Peter M. van der Kraan, Fons A. J. van de Loo
Publikováno v:
Frontiers in Medicine, Vol 10 (2024)
BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovial inflammation and cartilage/bone damage. Intercellular messengers such as IL-1 and TNF play a crucial role in the pathophysiology of RA but have limited dia
Externí odkaz:
https://doaj.org/article/0fdda973c7cd427699c6d95bfaeef970
Autor:
Maarten P. T. de Wit, M. I. Koenders, Y. Neijland, F. H. J. van den Hoogen, P. M. van der Kraan, F. A. J. van de Loo, H. Berkers, M. Lieon, A. van Caam, C. van den Ende
Publikováno v:
BMC Rheumatology, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract Background Empirical evidence for effective patient-researcher collaboration in basic research is lacking. This study aims to explore good working models and impact of patient involvement in basic rheumatology research and to identify barrie
Externí odkaz:
https://doaj.org/article/3651b2259dac4643a7c46697d05bcdbd
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Peng Wang, Onno J Arntz, Johanna F A Husch, Van der Kraan P M, Jeroen J J P van den Beucken, Fons A J van de Loo
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295076 (2023)
Mesenchymal stromal/stem cell derived-extracellular vesicles (MSC-EVs) have gained interest as drug delivery nanoparticles, having immunoregulatory and potentiating tissue repair property. To maintain growth of MSCs and obtain pure MSC-derived EVs, t
Externí odkaz:
https://doaj.org/article/f46dd13bbfb94307a9af8e9bac4042a0
Autor:
Natália Valdrighi, Arjen B. Blom, Juliana P. Vago, Henk M. van Beuningen, Elly L. Vitters, Monique M. Helsen, Birgitte Walgreen, Onno J. Arntz, Marije I. Koenders, Peter M. van der Kraan, Esmeralda N. Blaney Davidson, Fons A. J. van de Loo
Publikováno v:
Cells, Vol 12, Iss 14, p 1913 (2023)
Joint pain severity in arthritic diseases differs between sexes and is often more pronounced in women. This disparity is thought to stem from biological mechanisms, particularly innate immunity, yet the understanding of sex-specific differences in ar
Externí odkaz:
https://doaj.org/article/c4935f31599a45a9bccf4b49b14a63a7
Autor:
Juliana P. Vago, Natália Valdrighi, Esmeralda N. Blaney-Davidson, Daniel L. A. H. Hornikx, Margot Neefjes, María E. Barba-Sarasua, Nathalie G. M. Thielen, Martijn H. J. van den Bosch, Peter M. van der Kraan, Marije I. Koenders, Flávio A. Amaral, Fons A. J. van de Loo
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 703 (2023)
Osteoarthritis (OA) is the most prevalent joint disease, and it is characterized by cartilage degeneration, synovitis, and bone sclerosis, resulting in swelling, stiffness, and joint pain. TAM receptors (Tyro3, Axl, and Mer) play an important role in
Externí odkaz:
https://doaj.org/article/047bc96dcbe34cb9b01ef0b135fe48be
Autor:
Juan Fafián-Labora, Miriam Morente-López, María José Sánchez-Dopico, Onno J. Arntz, Fons A. J. van de Loo, Javier De Toro, María C. Arufe
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2020)
Abstract Introduction This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced ageing and pluripotency markers in cell cultures where they are added. Methods MSC-derived extracellular vesicles from old and you
Externí odkaz:
https://doaj.org/article/39565356b48f49d88502227fa058383f
Autor:
Joyce Aarts, Annemarie Boleij, Bartijn C. H. Pieters, Anouk L. Feitsma, R. J. Joost van Neerven, Jean Paul ten Klooster, Laura M’Rabet, Onno J. Arntz, Marije I. Koenders, Fons A. J. van de Loo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Many studies provided compelling evidence that extracellular vesicles (EVs) are involved in the regulation of the immune response, acting as both enhancers and dampeners of the immune system, depending on the source and type of vesicle. Research, inc
Externí odkaz:
https://doaj.org/article/7206aa4f590f40579215db13f8663deb
Autor:
Nathalie G. M. Thielen, Margot Neefjes, Elly L. Vitters, Henk M. van Beuningen, Arjen B. Blom, Marije I. Koenders, Peter L. E. M. van Lent, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Arjan P. M. van Caam, Peter M. van der Kraan
Publikováno v:
Cells, Vol 11, Iss 7, p 1232 (2022)
During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process. TGF-β’s signaling pathways can contribute to a hypertrophy(-like) phenotype in chondrocytes, especially at high doses of TGF-β. In this study, we examine
Externí odkaz:
https://doaj.org/article/a631d94a620f4eafa36cfb68ffd19d7e
Autor:
Howard W. Bruckner
Publikováno v:
Journal of cancer research and clinical oncology. 116(2)
Chemotherapy can achieve approximately 50% rates of response, survival advantage or both for every type of gastrointestinal tumor. Findings favor adjuvant therapy for all high-risk tumors. Test-worthy candidate regimens possibly increase safety and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e321202d895dfebf39f440fbefc009
https://pubmed.ncbi.nlm.nih.gov/2324167
https://pubmed.ncbi.nlm.nih.gov/2324167