Involvement of ceramide biosynthesis in increased extracellular vesicle release in Pkd1 knock out cells

Autor: Valentina Carotti, Jenny van der Wijst, Eric H. J. Verschuren, Luco Rutten, Nico Sommerdijk, Charlotte Kaffa, Vera Sommers, Juan P. Rigalli, Joost G. J. Hoenderop

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited disorder characterized by the development of renal cysts, which frequently leads to renal failure. Hypertension and other cardiovascular symptoms contribute to the high morbidity an

Externí odkaz: https://doaj.org/article/5502d777b83a4e51954e3c5d9191c76c

Protein Intake Falls below 0.6 g·kg-1·d-1 in Healthy, Older Patients Admitted for Elective Hip or Knee Arthroplasty

Autor: Imre W. K. Kouw, Jan Geurts, R. Muyters, A. A. J. Verschuren, Michelle E G Weijzen, P. Geerlings, Lex B. Verdijk, Pieter J. Emans, L.J.C. van Loon

Publikováno v: The Journal of Nutrition, Health & Aging
Journal of Nutrition Health & Aging, 23(3), 299-305. Springer

Objective Hospitalization is generally accompanied by changes in food intake. Patients typically receive hospital meals upon personal preference within the framework of the food administration services of the hospital. In the present study, we assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64eb807b9f3f73e9dbb398be140b7e96
http://europepmc.org/articles/PMC6399806

Sensing of tubular flow and renal electrolyte transport

Autor: Eric H J, Verschuren, Charlotte, Castenmiller, Dorien J M, Peters, Francisco J, Arjona, René J M, Bindels, Joost G J, Hoenderop

Publikováno v: Nature reviews. Nephrology. 16(6)

The kidney is a remarkable organ that accomplishes the challenge of removing waste from the body and simultaneously regulating electrolyte and water balance. Pro-urine flows through the nephron in a highly dynamic manner and adjustment of the reabsor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c37af11400953fdaa10105742106aff
https://pubmed.ncbi.nlm.nih.gov/32127698

Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD

Autor: Wouter N. Leonhard, Dorien J.M. Peters, Caro Overmars-Bos, Sami G. Mohammed, Kimberly A.M. Veraar, Eric H. J. Verschuren, Francisco J. Arjona, René J. M. Bindels, Joost G. J. Hoenderop

Publikováno v: American Journal of Physiology : Renal Physiology, 315, F537-F546
American Journal of Physiology : Renal Physiology, 315, 3, pp. F537-F546
American Journal of Physiology-Renal Physiology, 315(3), F537-F546

The PKD1 gene encodes polycystin-1 (PC1), a mechanosensor triggering intracellular responses upon urinary flow sensing in kidney tubular cells. Mutations in PKD1 lead to autosomal dominant polycystic kidney disease (ADPKD). The involvement of PC1 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e6e712e5dfde65ed83ca7e61cc471b
https://pubmed.ncbi.nlm.nih.gov/29767557

Quantitative analysis of HIV-1 protease inhibitors in cell lysates using MALDI-FTICR mass spectrometry

Autor: Jeroen J. A. van Kampen, Esther J. Verschuren, Theo M. Luider, Mariska L. Reedijk, Rob A. Gruters, Albert D. M. E. Osterhaus, Peter C. Burgers, Ronald de Groot

Publikováno v: Analytica Chimica Acta, 80, 10, pp. 3751-6
Analytica Chimica Acta, 80, 3751-6
Analytical Chemistry, 80(10), 3751-3756. American Chemical Society

Contains fulltext : 71284.pdf (Publisher’s version ) (Open Access) In this report we explore the use of MALDI-FTICR mass spectrometry for the quantitative analysis of five HIV-1 protease inhibitors in cell lysates. 2,5-Dihydroxybenzoic acid (DHB) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a0798c75930a051341877b180f3dcc
https://doi.org/10.1021/ac702072c