Výsledky vyhledávání - "A. A. Alshevskaya"

Akademický článek

Features of changes in the expression level of TNFα receptors and the functional response of cell lines upon stimulation with various doses of cytokine

Autor: Yu. A. Lopatnikova, Yu. V. Zhukova, A. A. Alshevskaya, I. A. Obleukhova, F. D. Kireev, I. A. Belomestnova, S. V. Sennikov

Publikováno v: Медицинская иммунология, Vol 25, Iss 3, Pp 459-464 (2023)

TNFa is a pro-inflammatory cytokine that is signaled through type 1 (TNFR1) and type 2 (TNFR2) receptors. TNFR1 normally mediates apoptosis, cell survival, and cytokine secretion, while TNFR2 selectively mediates cell survival and cytokine secretion.

Externí odkaz: https://doaj.org/article/90c612f004394c449523be0cc6a339af

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Akademický článek

Effect of different types of immunosuppressive therapy on the parameters of TNF receptor expression in patients with rheumatoid arthritis

Autor: A. A. Alshevskaya, J. V. Zhukova, J. A. Lopatnikova, F. D. Kireev, N. S. Shkaruba, O. A. Chumasova, J. A. Shevchenko, N. A. Ilina, A. E. Sizikov, S. V. Sennikov

Publikováno v: Acta Biomedica Scientifica, Vol 7, Iss 5-1, Pp 154-166 (2022)

Background. The balance of TNF receptor expression on immune cells is a key factor determining cytokine-induced activation of proapoptotic or proliferative signaling pathways. As a result, the changes in cytokine level and in expression of its recept

Externí odkaz: https://doaj.org/article/d7eeb1dcfce947a7b563a8cd06be6f4b

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Akademický článek

CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMA

Autor: Yu. V. Zhukova, A. A. Alshevskaya, F. D. Kireev, O. A. Chumasova, N. S. Shkaruba, A. E. Sizikov, Yu. A. Lopatnikova, D. V. Demina, A. V. Karaulov, A. N. Silkov, S. V. Sennikov

Publikováno v: Медицинская иммунология, Vol 23, Iss 4, Pp 903-908 (2021)

A pleiotropic cytokine TNFα is an important inflammatory mediator of a number of diseases; its biological functions are fulfilled through two different receptors, TNFR1 and TNFR2. Changes in the ratio between these types of receptors shifting the ba

Externí odkaz: https://doaj.org/article/482fd1a256c14ef8b21598e321ea6907

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Akademický článek

Efficiency of endovascular embolization and predictors of postoperative complications in patients with different types of brain arteriovenous malformations

Autor: A. S. Brusyanskaya, A. L. Krivoshapkin, K. Yu. Orlov, A. A. Alshevskaya, A. V. Moskalev, G. S. Sergeev, A. S. Gaytan, A. E. Simonovich

Publikováno v: Патология кровообращения и кардиохирургия, Vol 23, Iss 1, Pp 54-60 (2019)

Aim. (1) To evaluate the efficiency of endovascular embolization of brain arteriovenous malformations (AVMs) with seizure or hemorrhage in relation to radicalness and postoperative complication development and (2) to determine the predictors of posto

Externí odkaz: https://doaj.org/article/4707708620fb48ed844883466df46862

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Akademický článek

EXPRESSION DENSITY OF RECEPTORS FOR IMMUNOREGULATORY MEDIATORS AS A MODULATORY COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS UPON CELLS (PART 2)

Autor: S. V. Sennikov, A. A. Alshevskaya, Yu. V. Zhukova, I. A. Belomestnova, A. V. Karaulov, Yu. A. Lopatnikova

Publikováno v: Медицинская иммунология, Vol 21, Iss 3, Pp 379-396 (2019)

The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors a

Externí odkaz: https://doaj.org/article/18bc7b422fa24f5ab96ba8bd5a96743e

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Akademický článek

EXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 1

Autor: S. V. Sennikov, A. A. Alshevskaya, J. V. Zhukova, I. A. Belomestnova, A. V. Karaulov, J. A. Lopatnikova

Publikováno v: Медицинская иммунология, Vol 21, Iss 2, Pp 209-220 (2019)

Externí odkaz: https://doaj.org/article/9bb68a7e582048aba4f968c3bae3ff8e

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Akademický článek

ROLE OF TNFα/TNF-R1-SIGNALING PATHWAY IN CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST GLIOBLASTOMA CELL LINES

Autor: T. V. Tyrinova, S. V. Mishinov, O. Yu. Leplina, A. A. Alshevskaya, Yu. D. Kurochkina, E. A. Oleynik, А. V. Kalinovskiy, Yu. A. Lopatnikova, S. V. Chernov, V. V. Stupak, S. V. Sennikov, A. A. Ostanin, E. R. Chernykh

Publikováno v: Медицинская иммунология, Vol 20, Iss 3, Pp 353-364 (2018)

Dendritic cells (DCs) of patients with high-grade brain glioma exhibit impaired expression of membrane TNFα associated with low DC cytotoxicity against TNF-R1-expressing tumor cell line HEp-2. To assess the significance of these findings, we investi

Externí odkaz: https://doaj.org/article/55d82abeb5a845fca8999827edb477a9

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Akademický článek

TUMOR NECROSIS FACTOR-α MEMBRANE-BOUND AND SOLUBLE RECEPTORS IN NORM AND IN RHEUMATOID ARTHRITIS

Autor: A. A. Alshevskaya, F. F. Vasiliev, J. A. Lopatnikova, S. V. Sennikov

Publikováno v: Acta Biomedica Scientifica, Vol 0, Iss 3(2), Pp 23-28 (2012)

TNFα — a multifunctional pleiotropic cytokine, considered to have a special significance in the immunopathogenesis of rheumatoid arthritis. Herewith the effectiveness of immunomodulatory cytokine and its role in the development of pathological sta

Externí odkaz: https://doaj.org/article/0d9495723b1d4de8a34f6e6fa6e0a7e8

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