A genome-wide association meta-analysis identifies new childhood obesity loci

Autor: Craig E. Pennell, Chris Power, Johannes Hebebrand, David Meyre, Jean Dallongeville, Pma Sleiman, Mark I. McCarthy, Joel N. Hirschhorn, Nicholas J. Timpson, Nicole M. Warrington, Rjp van der Valk, Karani Santhanakrishnan Vimaleswaran, A Pouta, Mònica Guxens, Mariona Bustamante, Luis A. Moreno, M-R Jarvelin, Fredrick R. Schumacher, Aline Meirhaeghe, Charlotte E. Neville, Beatriz Valcarcel, Eleanor Wheeler, Hakon Hakonarson, Stephen O'Rahilly, D. S. Postma, Albert Hofman, Fernando Rivadeneira, Johan G. Eriksson, Hans Bisgaard, George McMahon, Vwv Jaddoe, I. S. Farooqi, Shikta Das, Diane J. Berry, Eskil Kreiner-Møller, Mohamed T. Hassanein, J. C. de Jongste, Joachim Heinrich, Olli T. Raitakari, Jessica L. Buxton, Aarno Palotie, W. J. Gauderman, Paul Elliott, C. Lecoeur, Reedik Mägi, Elina Hyppönen, C M van Duijn, B. St Pourcain, Frank D. Gilliland, Susan M. Ring, John P. Kemp, Rany M. Salem, Lyle J. Palmer, Terho Lehtimäki, Philippe Froguel, Ivonne Jarick, Cag Boreham, Elisabeth Thiering, Dorret I. Boomsma, Sfa Grant, A.-L. Hartikainen, André Scherag, Panagiotis Deloukas, Claus Holst, Jianhua Zhao, André G. Uitterlinden, Robert I. Berkowitz, Cecilia M. Lindgren, Tia Sorensen, Aif Blakemore, Mingyao Li, George Davey Smith, Dennis O. Mook-Kanamori, H R Taal, David M. Evans, Diana L. Cousminer, Matthew W. Gillman, Jonathan P. Bradfield, E. Widen, Anke Hinney, Inês Barroso

Publikováno v: Nature Genetics, 44(5), 526-531e1. Nature Publishing Group
Nature genetics, vol 44, iss 5
Nature Genetics, 44(5), 526-+. Nature Publishing Group
Nature Genetics; Vol 44
Nature genetics
Nature Genetics, 44(5), 526-532. Nature Publishing Group
Ожирение и метаболизм, Vol 9, Iss 1 (2012)
Bradfield, J P, Taal, H R, Timpson, N J, Scherag, A, Lecoeur, C, Warrington, N M, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, R M, Schumacher, F R, Cousminer, D L, Sleiman, P M A, Zhao, J, Berkowitz, R I, Vimaleswaran, K S, Jarick, I, Pennell, C E, Evans, D M, St Pourcain, B, Berry, D J, Mook-Kanamori, D O, Hofman, A, Rivadeneira, F, Uitterlinden, A G, van Duijn, C M, van der Valk, R J P, de Jongste, J C, Postma, D S, Boomsma, D I, Gauderman, W J, Hassanein, M T, Lindgren, C M, Mägi, R, Boreham, C A G, Neville, C E, Moreno, L A, Elliott, P, Pouta, A, Hartikainen, A-L, Li, M, Raitakari, O, Lehtimäki, T, Eriksson, J G, Palotie, A, Dallongeville, J, Das, S, Deloukas, P, McMahon, G, Ring, S M, Kemp, J P, Buxton, J L, Blakemore, A I F, Bustamante, M, Guxens, M, Hirschhorn, J N, Gillman, M W, Kreiner-Møller, E, Bisgaard, H, Gilliland, F D, Heinrich, J, Wheeler, E, Barroso, I, O'Rahilly, S, Meirhaeghe, A, Sørensen, T I A, Power, C, Palmer, L J, Hinney, A, Widen, E, Farooqi, I S, McCarthy, M I, Froguel, P, Meyre, D, Hebebrand, J, Järvelin, M J, Jaddoe, V W V, Smith, G D, Hakonarson, H & Grant, S F A 2012, ' A genome-wide association meta-analysis identifies new childhood obesity loci ', Nature Genetics, vol. 44, no. 5, pp. 526-532 . https://doi.org/10.1038/ng.2247
Nature Genetics

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Austra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f880f61d6afe73241feeb22a7a0f214a
https://ora.ox.ac.uk/objects/uuid:96f4bbd6-9965-4488-bd10-c99d0e45ba6b

Menstrual disorders in adolescence: a marker for hyperandrogenaemia and increased metabolic risks in later life? Finnish general population-based birth cohort study

Autor: P. Pinola, Katri Puukka, Hany Lashen, Hannu Martikainen, Anneli Pouta, Aimo Ruokonen, Steve Franks, A.-L. Hartikainen, Aini Bloigu, M. Ulmanen, Marjo-Riitta Järvelin, Laure Morin-Papunen

Publikováno v: Human Reproduction. 27:3279-3286

STUDY QUESTION Are self-reported menstrual disorders associated with hyperandrogenaemia and metabolic disturbances as early as in adolescence? SUMMARY ANSWER Menstrual disorders at the age 16 are a good marker of hyperandrogenaemia, and an adverse li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40f62098167d396fdd82995726685fb
https://doi.org/10.1093/humrep/des309

The association of body mass index, waist and hip circumference, and waist–hip ratio with Chlamydia pneumoniae IgG antibodies and high-sensitive C-reactive protein at 31 years of age in Northern Finland Birth Cohort 1966

Autor: A.-L. Hartikainen, Markku J. Savolainen, Jaana Laitinen, Aimo Ruokonen, Aini Bloigu, Anneli Pouta, Pekka Saikku, Maija Leinonen, Mika Paldanius, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Taina K. Lajunen

Publikováno v: International Journal of Obesity. 35:1470-1478

Viruses and bacteria like Chlamydia pneumoniae and Helicobacter pylori have been suggested to have a role in pathogenesis of overweight and obesity.We studied whether C. pneumoniae-specific IgG antibodies are associated with elevated body mass index

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31234d0ee9169691eb2802da46fca44a
https://doi.org/10.1038/ijo.2011.21

Treating miscarriages: a randomised study of cost-effectiveness in medical or surgical choice

Autor: Maarit Niinimäki, A.-L. Hartikainen, Pouta A, P. Karinen

Publikováno v: BJOG: An International Journal of Obstetrics & Gynaecology. 116:984-990

Objective The aim was to carry out a cost effectiveness analysis (CEA) of medical and surgical treatment of miscarriage using quantitative and qualitative indicators. Design A prospective study where the data of the clinical course of the treatment a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0161ffc32eca90759204afa8e0f163f
https://doi.org/10.1111/j.1471-0528.2009.02161.x

Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF

Autor: Sari Koivurova, A.-L. Hartikainen, Ulla Sovio, Marjo-Riitta Järvelin, Mika Gissler, Elina Hemminki

Publikováno v: Human Reproduction. 18:2328-2336

BACKGROUND: To examine the long-term child outcome after IVF until the age of 3 years in Northern Finland, we conducted a population-based cohort study. METHODS: First, a cohort of 299 IVF children born in 1990-1995 was compared with a cohort of 558

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fcc5f59f585261ad45a54a777e6a28
https://doi.org/10.1093/humrep/deg445