Výsledky vyhledávání

The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413

Autor: Yvonne Connolly Martin

Publikováno v: International Journal of Medicinal Chemistry
International Journal of Medicinal Chemistry, Vol 2011 (2011)

The novel selective D1 dopaminergic full agonists A-68930, A-77636 were discovered by the synthesis of molecules to probe the bioactive conformation of the partial agonist SKF-38393, by the use of this information to add D1 affinity and selectivity t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5390b5e826fb12ec3d616bd090c6bf15
https://doi.org/10.1155/2011/424535

Zobrazit plný text záznamu

The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats

Autor: Steven J. Cooper, Peter G. Clifton, Hessah A. Al-Naser

Publikováno v: European Journal of Pharmacology. 532:253-257

Free-feeding rats meet much of their daily energy requirements by consuming food in meals during the nocturnal phase of the night/day cycle. Meal pattern analysis methodology has been developed to record the patterns of meal taken over a 24-h period,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c724fccea83fab9949bb31bf552439b6
https://doi.org/10.1016/j.ejphar.2005.11.046

Zobrazit plný text záznamu

Comparison of interactions of D1-like agonists, SKF 81297, SKF 82958 and A-77636, with cocaine: locomotor activity and drug discrimination studies in rodents

Autor: Allison L. Chausmer, Jonathan L. Katz

Publikováno v: Psychopharmacology. 159:145-153

Rationale: Recent data suggest that dopamine (DA) D1-like receptor full agonists may be potential pharmacotherapeutic agents for treating cocaine abuse. The structurally novel isochroman D1-like agonist, A-77636, has not been well characterized and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d17df1b6e78b5bf6a31b481eb0b6175
https://doi.org/10.1007/s002130100896

Zobrazit plný text záznamu

Dopamine D1 receptor desensitization profile in MPTP-lesioned primates

Autor: Pierre Blanchet, Paul J. Bédard, Donald R. Britton, Kazumi Shiosaki, Richard Grondin

Publikováno v: European Journal of Pharmacology. 309:13-20

The motor effects of dopamine D1 receptor activation and the optimal way to stimulate these receptors were studied in a primate model of parkinsonism induced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), using 2 selective ful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5481ef5486da21e18b1b170c20f0fe9
https://doi.org/10.1016/0014-2999(96)00309-3

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Actions of the D1 agonists A-77636 and A-86929 on locomotion and dyskinesia in MPTP-treated L-dopa-primed common marmosets

Autor: C. D. Marsden, Donald R. Britton, Peter Jenner, R. K. B. Pearce, Michael J. Jackson, K. Shiosaki

Publikováno v: Psychopharmacology. 142(1)

Common marmosets show parkinsonian motor deficits following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration and develop dyskinesias during chronic L-dopa exposure. The D1 agonists A-77636 [(1R, 3S) 3-(1'-adamantyl)-1-aminomethyl-3,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd329667c67e84fbe3826949effa0d1
https://pubmed.ncbi.nlm.nih.gov/10102782

Zobrazit plný text záznamu

D1 dopamine receptors mediate neuroleptic-induced Fos expression in the islands of Calleja

Autor: David Wirtshafter

Publikováno v: Synapse (New York, N.Y.). 28(2)

Systemic injections of the selective, full, D1 agonists A-77636 and SKF-82958 induced pronounced Fos-like immunoreactivity in the islands of Calleja in the olfactory tubercle of intact rats. Fos expression in this region could also be induced by inje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7dabb134ee07ecd93900b5707b8c72
https://pubmed.ncbi.nlm.nih.gov/9450515

Zobrazit plný text záznamu

Compartmentally specific effects of quinpirole on the striatal Fos expression induced by stimulation of D1-dopamine receptors in intact rats

Autor: Greg Schardt, Karen E. Asin, David Wirtshafter

Publikováno v: Brain research. 771(2)

Injections of the full D1-agonist A-77636 (1.45 mg/kg) were found to induce clear Fos-like immunoreactivity (FLI) in the striatum of neurologically intact rats. Pretreatment with the D2-like agonist quinpirole (3 mg/kg) potentiated staining in the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c31e4d88ca98f15a4871252ad907ae3
https://pubmed.ncbi.nlm.nih.gov/9401747

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Effects of YM 435 and A 77636 on dopamine D-1 receptors in bovine retina in vitro

Autor: Olivier Bugnon, Saskia de Raad, Senyo Ofori, Michel Schorderet

Publikováno v: General pharmacology. 26(1)

1. 1. Homogenates of bovine retinas were used to study the capacities of two new dopamine (DA) receptor agonists, e.g. YM 435 and A 77636, to interact with D1 receptors. 2. 2. Adenylate cyclase experiments. YM 435 and A 77636 enhanced cAMP accumulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6c7326d66d2e04e1f7cdd757f78246
https://pubmed.ncbi.nlm.nih.gov/7713366

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání