Zobrazeno 1 - 10
of 128
pro vyhledávání: '"A disintegrin and metalloprotease 17"'
Autor:
Stephanie A. Azzopardi, Hsiu-Yi Lu, Sebastien Monette, Ariana I. Rabinowitsch, Jane E. Salmon, Hiroaki Matsunami, Carl P. Blobel
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6079 (2024)
The cell surface metalloprotease ADAM17 (a disintegrin and metalloprotease 17) and its binding partners iRhom2 and iRhom1 (inactive Rhomboid-like proteins 1 and 2) modulate cell–cell interactions by mediating the release of membrane proteins such a
Externí odkaz:
https://doaj.org/article/7db20e5d0d3245cf9142d4fc216faa8e
Autor:
Garima Dixit, Jesus Gonzalez‐Bosquet, Joseph Skurski, Eric J. Devor, Erin B. Dickerson, Warren B. Nothnick, Priya D. Issuree, Kimberly K. Leslie, Thorsten Maretzky
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Abstract Background Mutations in the receptor tyrosine kinase gene fibroblast growth factor receptor 2 (FGFR2) occur at a high frequency in endometrial cancer (EC) and have been linked to advanced and recurrent disease. However, little is known about
Externí odkaz:
https://doaj.org/article/e1ddfbedbc6649e691ed24abee9aaa3f
Publikováno v:
Cells, Vol 12, Iss 18, p 2227 (2023)
Functional analysis of somatic mutations in tumorigenesis facilitates the development and optimization of personalized therapy for cancer patients. The fibroblast growth factor receptor 2 (FGFR2) gene is frequently mutated in endometrial cancer (EC),
Externí odkaz:
https://doaj.org/article/74b0a621ffb04cfa8e64e15f545f4c39
Akademický článek
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Autor:
Wagdi Almishri, Liam A. Swain, Charlotte D’Mello, Tyson S. Le, Stefan J. Urbanski, Henry H. Nguyen
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) is a ubiquitously expressed membrane-bound enzyme that mediates shedding of a wide variety of important regulators in inflammation including cytokines and adhesion molecules. Hep
Externí odkaz:
https://doaj.org/article/baa61ac6f41f44bd872a34e0752f00ef
Autor:
Yi Zhao, Eliud Morales Dávila, Xue Li, Beiyu Tang, Ariana I. Rabinowitsch, Jose Manuel Perez-Aguilar, Carl P. Blobel
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12796 (2022)
The metalloprotease ADAM17 is a key regulator of the TNFα, IL-6R and EGFR signaling pathways. The maturation and function of ADAM17 is controlled by the seven-membrane-spanning proteins iRhoms1 and 2. The functional properties of the ADAM17/iRhom1 a
Externí odkaz:
https://doaj.org/article/df8df69f016e4ae18d9d78c59a6d1132
Autor:
Hemant K. Mishra, Kate J. Dixon, Nabendu Pore, Martin Felices, Jeffrey S. Miller, Bruce Walcheck
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer (NK) cells are innate cytotoxic lymphocytes that can recognize assorted determinants on tumor cells and rapidly kill these cells. Due to their anti-tumor effector functions and potential for allogeneic use, various NK cell platforms ar
Externí odkaz:
https://doaj.org/article/27002e9de420433699fba065559dac2a
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 109, Iss , Pp 1907-1914 (2019)
NADPH oxidases (Noxs) 1/4 dual inhibitor GKT137831 prevents hypertensive cardiac remodelling in angiotensin II-infused transgenic mice with cardiomyocyte-specific human Nox4 (c-hNo x 4 Tg); however, further research is still required to determine the
Externí odkaz:
https://doaj.org/article/dd609a6b35544ac59682b637da7fee37
Akademický článek
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Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 4, Pp 1632-1644 (2018)
Background/Aims: High-mobility group box 1 (HMGB1) elicits inflammatory responses through interactions with the receptor for advanced glycation end products (RAGE) and toll-like receptor 4 (TLR4). We investigated how RAGE and TLR4 expressions are reg
Externí odkaz:
https://doaj.org/article/79c2c8573ba245859529a94746639f7d