Zobrazeno 1 - 10
of 132
pro vyhledávání: '"A Yaël, Nossent"'
Autor:
Korina Karagianni, Alessia Bibi, Alisia Madé, Shubhra Acharya, Mikko Parkkonen, Teodora Barbalata, Prashant K. Srivastava, David de Gonzalo-Calvo, Constanza Emanueli, Fabio Martelli, Yvan Devaux, Dimitra Dafou, A. Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102085- (2024)
RNA editing, a common and potentially highly functional form of RNA modification, encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. As inosines are interpreted as guanosines by
Externí odkaz:
https://doaj.org/article/02ae5e2b9de447f4986105af97021dfe
Autor:
Gaia Spinetti, Martina Mutoli, Simona Greco, Federica Riccio, Soumaya Ben-Aicha, Franziska Kenneweg, Amela Jusic, David de Gonzalo-Calvo, Anne Yaël Nossent, Susana Novella, Georgios Kararigas, Thomas Thum, Costanza Emanueli, Yvan Devaux, Fabio Martelli
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-28 (2023)
Abstract Diabetes mellitus, a group of metabolic disorders characterized by high levels of blood glucose caused by insulin defect or impairment, is a major risk factor for cardiovascular diseases and related mortality. Patients with diabetes experien
Externí odkaz:
https://doaj.org/article/86536cc3ef5341cd87a82ec63426c4bd
Autor:
Florijn, Barend W., Leontien van der Bent, M., Nguyen, Truc My T., Quax, Paul H.A., Wermer, Marieke J.H., Yaël Nossent, A., Kruyt, Nyika D.
Publikováno v:
In Journal of Stroke and Cerebrovascular Diseases November 2023 32(11)
Autor:
Mamta Jain, Greeshma Manjaly, Kathrin Maly, Margreet R. de Vries, Michael Janisiw, Lisa König, Anne Yaël Nossent, Michael F. Jantsch
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 522-534 (2022)
Adenosine to inosine (A to I) editing is mediated by adenosine deaminases acting on RNA (ADAR) enzymes. Inosines are interpreted as guanosines by the translational machinery. Consequently, A to I editing in mRNAs can lead to their recoding and the fo
Externí odkaz:
https://doaj.org/article/2af89efb42d1445db50a12175ae6966e
Autor:
Eva van Ingen, Pleun A.M. Engbers, Tamar Woudenberg, M. Leontien van der Bent, Hailiang Mei, Johann Wojta, Paul H.A. Quax, A. Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 162-172 (2022)
C/D box small nucleolar RNAs (snoRNAs) of the DLK1-DIO3 locus are associated with vascular remodeling and cardiovascular disease. None of these snoRNAs has any known targets yet except for one, AF357425/SNORD113-6. We previously showed that this snoR
Externí odkaz:
https://doaj.org/article/611b5447849f4d83868b5251b99cc594
Autor:
Veerle Kremer, Diewertje I. Bink, Laura Stanicek, Eva van Ingen, Theresa Gimbel, Sarah Hilderink, Stefan Günther, Anne Yaël Nossent, Reinier A. Boon
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract A large portion of the genome is transcribed into non-coding RNA, which does not encode protein. Many long non-coding RNAs (lncRNAs) have been shown to be involved in important regulatory processes such as genomic imprinting and chromatin mo
Externí odkaz:
https://doaj.org/article/3bc5639ebbcb4d0fa042463c3214f86d
Autor:
Eva van Ingen, Amanda C. Foks, Tamar Woudenberg, M. Leontien van der Bent, Alwin de Jong, Philipp J. Hohensinner, Johann Wojta, Ilze Bot, Paul.H.A. Quax, Anne Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1228-1239 (2021)
We have previously shown that treatment with third-generation antisense oligonucleotides against miR-494-3p (3GA-494) reduces atherosclerotic plaque progression and stabilizes lesions, both in early and established plaques, with reduced macrophage co
Externí odkaz:
https://doaj.org/article/3c732ba897314891bf7651163691b08a
Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia
Autor:
Reginald V.C.T. van der Kwast, Laura Parma, M. Leontien van der Bent, Eva van Ingen, Fabiana Baganha, Hendrika A.B. Peters, Eveline A.C. Goossens, Karin H. Simons, Meindert Palmen, Margreet R. de Vries, Paul H.A. Quax, A. Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 932-953 (2020)
Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs’ targetomes and thus their function. Using public RNA-sequencing data, we identified 35 vasoactive microRNAs that are A-to-I edited. We quantified A-to-
Externí odkaz:
https://doaj.org/article/2209272f4f534aa0b0f07a3770ab3c50
Autor:
Eva van Ingen, Amanda C. Foks, Mara J. Kröner, Johan Kuiper, Paul H.A. Quax, Ilze Bot, Anne Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 638-649 (2019)
We have previously shown that third-generation antisense (3GA) inhibition of 14q32 microRNA (miRNA)-494 reduced early development of atherosclerosis. However, patients at risk of atherosclerotic complications generally present with advanced and unsta
Externí odkaz:
https://doaj.org/article/c0ecfbcecf4a4e57b8835ececd858d65
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