Zobrazeno 1 - 10
of 340
pro vyhledávání: '"A Y Warren"'
Autor:
Nikita Sushentsev, Gregory Hamm, Lucy Flint, Daniel Birtles, Aleksandr Zakirov, Jack Richings, Stephanie Ling, Jennifer Y. Tan, Mary A. McLean, Vinay Ayyappan, Ines Horvat Menih, Cara Brodie, Jodi L. Miller, Ian G. Mills, Vincent J. Gnanapragasam, Anne Y. Warren, Simon T. Barry, Richard J. A. Goodwin, Tristan Barrett, Ferdia A. Gallagher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Hyperpolarised magnetic resonance imaging (HP-13C-MRI) has shown promise as a clinical tool for detecting and characterising prostate cancer. Here we use a range of spatially resolved histological techniques to identify the biological mechan
Externí odkaz:
https://doaj.org/article/5d269719830146bfb19310f180c8fbe9
Autor:
Ines Horvat-Menih, Hao Li, Andrew N. Priest, Shaohang Li, Andrew B. Gill, Iosif A. Mendichovszky, Susan T. Francis, Anne Y. Warren, Brent O’Carrigan, Sarah J. Welsh, James O. Jones, Antony C. P. Riddick, James N. Armitage, Thomas J. Mitchell, Grant D. Stewart, Ferdia A. Gallagher
Publikováno v:
European Radiology Experimental, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract Background Clinical imaging tools to probe aggressiveness of renal masses are lacking, and T2-weighted imaging as an integral part of magnetic resonance imaging protocol only provides qualitative information. We developed high-resolution and
Externí odkaz:
https://doaj.org/article/b6c4ff0758a645e8b1e1748405028287
Autor:
Thomas J Mitchell, Hao Li, Grant D Stewart, Anne Y Warren, James N Armitage, Ferdia A Gallagher, Mary A McLean, Andrew N Priest, Andrew B Gill, Iosif Mendichovszky, João Duarte, Ines Horvat-Menih, Maria Jesus Zamora-Morales, Marta Wylot, Joshua Kaggie, Alixander S Khan, Matthew J Locke, Sarah J Welsh, James O Jones
Publikováno v:
BMJ Open, Vol 14, Iss 10 (2024)
Introduction Localised renal masses are an increasing burden on healthcare due to the rising number of cases. However, conventional imaging cannot reliably distinguish between benign and malignant renal masses, and renal mass biopsies are unable to c
Externí odkaz:
https://doaj.org/article/90752ec8113d439d8fdb872d49956c6c
Autor:
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S. H. Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R. Zecchini, Sabrina H. Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y. Warren, Grant D. Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Primary and metastatic tumours have different metabolic phenotypes due to changes in nutrient availability. Here the authors perform multi-omic analyses of primary and metastatic renal cancer cells grown in a physiological medium and show that the re
Externí odkaz:
https://doaj.org/article/5e44e98a96b7403ead5d644996d99bb6
Autor:
Ludovic Wesolowski, Jianfeng Ge, Leticia Castillon, Debora Sesia, Anna Dyas, Shoko Hirosue, Veronica Caraffini, Anne Y. Warren, Paulo Rodrigues, Giovanni Ciriello, Saroor A. Patel, Sakari Vanharanta
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107360- (2023)
Summary: Lineage switching can induce therapy resistance in cancer. Yet, how lineage fidelity is maintained and how it can be lost remain poorly understood. Here, we have used CRISPR-Cas9-based genetic screening to demonstrate that loss of SMARCB1, a
Externí odkaz:
https://doaj.org/article/629e571c05cc491594e2cb0fca3f5f9e
Autor:
Claudia Buhigas, Anne Y. Warren, Wing-Kit Leung, Hayley C. Whitaker, Hayley J. Luxton, Steve Hawkins, Jonathan Kay, Adam Butler, Yaobo Xu, Dan J. Woodcock, Sue Merson, Fiona M. Frame, Atef Sahli, Federico Abascal, CRUK-ICGC Prostate Cancer Group, Iñigo Martincorena, G. Steven Bova, Christopher S. Foster, Peter Campbell, Norman J. Maitland, David E. Neal, Charlie E. Massie, Andy G. Lynch, Rosalind A. Eeles, Colin S. Cooper, David C. Wedge, Daniel S. Brewer
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied W
Externí odkaz:
https://doaj.org/article/ab88a2ce376d486096a3008701e9592f
Autor:
Thomas R. W. Oliver, Lia Chappell, Rashesh Sanghvi, Lauren Deighton, Naser Ansari-Pour, Stefan C. Dentro, Matthew D. Young, Tim H. H. Coorens, Hyunchul Jung, Tim Butler, Matthew D. C. Neville, Daniel Leongamornlert, Mathijs A. Sanders, Yvette Hooks, Alex Cagan, Thomas J. Mitchell, Isidro Cortes-Ciriano, Anne Y. Warren, David C. Wedge, Rakesh Heer, Nicholas Coleman, Matthew J. Murray, Peter J. Campbell, Raheleh Rahbari, Sam Behjati
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The molecular characterisation of germ cell tumours (GCT) is necessary to understand their development and histological diversification. Here, the authors use whole-genome and transcriptome sequencing of GCTs across distinct histologies to reveal the
Externí odkaz:
https://doaj.org/article/a04dee3f9628403093fe2d0a118a0411
Autor:
Nikita Sushentsev, Mary A. McLean, Anne Y. Warren, Arnold J. V. Benjamin, Cara Brodie, Amy Frary, Andrew B. Gill, Julia Jones, Joshua D. Kaggie, Benjamin W. Lamb, Matthew J. Locke, Jodi L. Miller, Ian G. Mills, Andrew N. Priest, Fraser J. L. Robb, Nimish Shah, Rolf S. Schulte, Martin J. Graves, Vincent J. Gnanapragasam, Kevin M. Brindle, Tristan Barrett, Ferdia A. Gallagher
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Your paper will be accompanied by the following editor’s summary. Please let us know if there are any inaccuracies: ‘Hyperpolarised ¹³C-MRI is used to image cancer metabolism. Here the authors use this technique in prostate cancer and show that
Externí odkaz:
https://doaj.org/article/e123d7318aa540b1a93cc058ead13ca5
Autor:
Stephan Ursprung, Helen Mossop, Ferdia A. Gallagher, Evis Sala, Richard Skells, Jamal A. N. Sipple, Thomas J. Mitchell, Anita Chhabra, Kate Fife, Athena Matakidou, Gemma Young, Amanda Walker, Martin G. Thomas, Mireia Crispin Ortuzar, Mark Sullivan, Andrew Protheroe, Grenville Oades, Balaji Venugopal, Anne Y. Warren, John Stone, Tim Eisen, James Wason, Sarah J. Welsh, Grant D. Stewart
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Window-of-opportunity trials, evaluating the engagement of drugs with their biological target in the time period between diagnosis and standard-of-care treatment, can help prioritise promising new systemic treatments for later-pha
Externí odkaz:
https://doaj.org/article/c51c1579691f49dabf5c4459307d8325
Autor:
Maxine G. B. Tran, Becky A. S. Bibby, Lingjian Yang, Franklin Lo, Anne Y. Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine M. L. West, Ian G. Mills, David E. Neal
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progression to castrate-resi
Externí odkaz:
https://doaj.org/article/a61b7426f5e348d59ed0525382172b14