Zobrazeno 1 - 10
of 608
pro vyhledávání: '"A Y, Ip"'
Autor:
Genevieve I. Cezard, Rachel E. Denholm, Rochelle Knight, Yinghui Wei, Lucy Teece, Renin Toms, Harriet J. Forbes, Alex J. Walker, Louis Fisher, Jon Massey, Lisa E. M. Hopcroft, Elsie M. F. Horne, Kurt Taylor, Tom Palmer, Marwa Al Arab, Jose Ignacio Cuitun Coronado, Samantha H. Y. Ip, Simon Davy, Iain Dillingham, Sebastian Bacon, Amir Mehrkar, Caroline E. Morton, Felix Greaves, Catherine Hyams, George Davey Smith, John Macleod, Nishi Chaturvedi, Ben Goldacre, William N. Whiteley, Angela M. Wood, Jonathan A. C. Sterne, Venexia Walker, On behalf of the Longitudinal Health and Wellbeing and Data and Connectivity UK COVID-19 National Core Studies, CONVALESCENCE study and the OpenSAFELY collaborative
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Infection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased risk are uncertain. With the approval of NHS England, we quantified associations
Externí odkaz:
https://doaj.org/article/8a4818423eb6468f9ff2d299b40e1da8
Autor:
Xiao Wang, Chun-fung Sin, Kay-Cheong Teo, William C. Y. Leung, Yuen-Kwun Wong, Roxanna K. C. Liu, Joshua W. Fok, Bonaventure Y. Ip, Hon Hang Kwan, Tsz Ching Lee, Bun Sheng, Edwin Kin-Keung Yip, Desmond Y. H. Yap, Hao Luo, Kui-Kai Lau
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundAlthough renal dysfunction is associated with adverse clinical outcomes in patients with atrial fibrillation (AF) following stroke, the impact of renal function variability is unclear.AimThis study aimed to assess the association between re
Externí odkaz:
https://doaj.org/article/e19339dc63494ca480aa138da2bd6909
Autor:
Xiaopu Zhou, Yu Chen, Fanny C. F. Ip, Yuanbing Jiang, Han Cao, Ge Lv, Huan Zhong, Jiahang Chen, Tao Ye, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M. N. Lo, Estella P. S. Tong, Alzheimer’s Disease Neuroimaging Initiative, Vincent C. T. Mok, Timothy C. Y. Kwok, Qihao Guo, Kin Y. Mok, Maryam Shoai, John Hardy, Lei Chen, Amy K. Y. Fu, Nancy Y. Ip
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-20 (2023)
Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.
Externí odkaz:
https://doaj.org/article/1179b0a6657942b580123646d3f1699e
Autor:
Sarah E. Morgan, Kelly Diederen, Petra E. Vértes, Samantha H. Y. Ip, Bo Wang, Bethany Thompson, Arsime Demjaha, Andrea De Micheli, Dominic Oliver, Maria Liakata, Paolo Fusar-Poli, Tom J. Spencer, Philip McGuire
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Recent work has suggested that disorganised speech might be a powerful predictor of later psychotic illness in clinical high risk subjects. To that end, several automated measures to quantify disorganisation of transcribed speech have been p
Externí odkaz:
https://doaj.org/article/144b58ca9ad7474c97100a6f5e06959e
Autor:
Jong‐Chan Park, Natalia Barahona‐Torres, So‐Yeong Jang, Kin Y. Mok, Haeng Jun Kim, Sun‐Ho Han, Kwang‐Hyun Cho, Xiaopu Zhou, Amy K. Y. Fu, Nancy Y. Ip, Jieun Seo, Murim Choi, Hyobin Jeong, Daehee Hwang, Dong Young Lee, Min Soo Byun, Dahyun Yi, Jong Won Han, Inhee Mook‐Jung, John Hardy
Publikováno v:
Advanced Science, Vol 9, Iss 23, Pp n/a-n/a (2022)
Abstract Recent multi‐omics analyses paved the way for a comprehensive understanding of pathological processes. However, only few studies have explored Alzheimer’s disease (AD) despite the possibility of biological subtypes within these patients.
Externí odkaz:
https://doaj.org/article/34ef263cdb004c159da392487b587d25
Autor:
Tao Ye, Yangyang Duan, Hayley W. S. Tsang, He Xu, Yuewen Chen, Han Cao, Yu Chen, Amy K. Y. Fu, Nancy Y. Ip
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Ye et al demonstrate a simple and precise method to simultaneously generate iPSC lines with different gene dosages using paired Cas9 nickases. As proof-of-concept they apply this method to examining amyloid precursor protein gene dosage effects in an
Externí odkaz:
https://doaj.org/article/70fb7c21e42e47428a1ea40e2a8b140e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no disease-modifying treatment. AD progression is characterized by cognitive decline, neuroinflammation, and accumulation of amyloid-beta (Aβ) and neurofibrillary t
Externí odkaz:
https://doaj.org/article/5e145d10ba444c13a408a1dd72b67715
Autor:
Xiaopu Zhou, Yu Chen, Kin Y. Mok, Timothy C. Y. Kwok, Vincent C. T. Mok, Qihao Guo, Fanny C. Ip, Yuewen Chen, Nandita Mullapudi, Alzheimer’s Disease Neuroimaging Initiative, Paola Giusti-Rodríguez, Patrick F. Sullivan, John Hardy, Amy K. Y. Fu, Yun Li, Nancy Y. Ip
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that
Externí odkaz:
https://doaj.org/article/daea0c2091424966946bd2ca4738d8a4
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100265- (2021)
Summary: Alzheimer’s disease is characterized by the deposition of extracellular amyloid-beta (Aβ) plaques. While microglial phagocytosis is a major mechanism through which Aβ is cleared, there is no method for quantitatively assessing Aβ phagoc
Externí odkaz:
https://doaj.org/article/514f5532dde84821974f2de429157a39
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health. Recent epidemiological and genetics studies have revealed the polygenic nature of
Externí odkaz:
https://doaj.org/article/49529fe61adf44eb80ba224f1f28c0ff