Zobrazeno 1 - 10
of 36
pro vyhledávání: '"A William, Tank"'
Publikováno v:
Journal of Neurochemistry. 109:1272-1284
Repeated nicotine administration induces tyrosine hydroxylase (TH) mRNA in rat midbrain. In this study we investigate the mechanisms responsible for this response using two models of midbrain dopamine neurons, rat ventral midbrain slice explant cultu
Publikováno v:
Molecular Pharmacology. 73:1816-1828
During prolonged stress or chronic treatment with neurotoxins, robust compensatory mechanisms occur that maintain sufficient levels of catecholamine neurotransmitters in terminal regions. One of these mechanisms is the up-regulation of tyrosine hydro
Autor:
Ross J. Bland, Margarita Rzhetskaya, A. William Tank, Nikolai Kholodilov, Xiqun Chen, Robert E. Burke, Matthew J. During, Tatyana Kareva
Publikováno v:
The Journal of Neuroscience. 28:672-680
There is extensive evidence that the mitogen-activated protein kinase (MAPK) signaling cascade mediates programmed cell death in neurons. However, current evidence that the mixed linage kinases (MLKs), upstream in this cascade, mediate cell death is
Autor:
Dona L. Wong, A. William Tank
Publikováno v:
Comprehensive Physiology
Physical challenges, emotional arousal, increased physical activity, or changes in the environment can evoke stress, requiring altered activity of visceral organs, glands, and smooth muscles. These alterations are necessary for the organism to functi
Publikováno v:
Journal of Neurochemistry. 94:731-741
Prolonged stress or chronic nicotine administration leads to induction of tyrosine hydroxylase (TH) in adrenal medulla and locus coeruleus (LC) of the rat. In this study we use mice that express a transgene encoding 4.5 kb of TH gene 5'-flanking regi
Autor:
Baoyong Sun, A. William Tank
Publikováno v:
Journal of Neurochemistry. 85:1421-1430
Tyrosine hydroxylase (TH) gene transcription rate increases in response to numerous pharmacological and physiological stimuli. The AP1 site within the TH gene proximal promoter is thought to play an important role in mediating many of these responses
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 304:575-588
Nicotine is a powerful stimulant of the sympathoadrenal system, causing the release of peripheral catecholamines and activation of catecholamine biosynthesis. In previous reports, we have studied the mechanisms by which short-term nicotine treatment
Autor:
Baoyong Sun, A. William Tank
Publikováno v:
Journal of Neurochemistry. 80:295-306
The AP1 site within the tyrosine hydroxylase gene proximal promoter is essential for the response of the gene to numerous stimuli. Stimulation of this gene is often associated with induction of the AP1 transcription factor, c-Fos. However, many stimu
Autor:
Cheryl A. Osterhout, Yang Chen, Joseph A Best, A. William Tank, Kristen M. Piech-Dumas, Kumi Nagamoto-Combs
Publikováno v:
Journal of Neurochemistry. 76:1376-1385
Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). Mutagenesis of either the cAMP responsive element (CRE) or the activator protein-1 elemen