Zobrazeno 1 - 10
of 1 306
pro vyhledávání: '"A W Wilkinson"'
Autor:
Brajesh P. Kaistha, Gozde Kar, Andreas Dannhorn, Amanda Watkins, Grace Opoku-Ansah, Kristina Ilieva, Stefanie Mullins, Judith Anderton, Elena Galvani, Fabien Garcon, Jean-Martin Lapointe, Lee Brown, James Hair, Tim Slidel, Nadia Luheshi, Kelli Ryan, Elizabeth Hardaker, Simon Dovedi, Rakesh Kumar, Robert W. Wilkinson, Scott A. Hammond, Jim Eyles
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
CD73 is a cell surface 5’nucleotidase (NT5E) and key node in the catabolic process generating immunosuppressive adenosine in cancer. Using a murine monoclonal antibody surrogate of Oleclumab, we investigated the effect of CD73 inhibition in concert
Externí odkaz:
https://doaj.org/article/77e22888da5c497ca0ad20c12534fc99
Autor:
R. Martin, K. E. Mullin, N. F. D. White, N. Grimason, R. Jehle, J. W. Wilkinson, P. Orozco‐terWengel, A. A. Cunningham, S. T. Maddock
Publikováno v:
Ecology and Evolution, Vol 14, Iss 9, Pp n/a-n/a (2024)
Abstract Studies in evolution, ecology and conservation are increasingly based on genetic and genomic data. With increased focus on molecular approaches, ethical concerns about destructive or more invasive techniques need to be considered, with a pus
Externí odkaz:
https://doaj.org/article/d07d74a69ae447bb827f9156d54a3dba
Autor:
Suzanne I. Sitnikova, Jennifer A. Walker, Laura B. Prickett, Michelle Morrow, Viia E. Valge-Archer, Matthew J. Robinson, Robert W. Wilkinson, Simon J. Dovedi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionImmuno-oncology (IO) research relies heavily on murine syngeneic tumor models. However, whilst the average age for a cancer diagnosis is 60 years or older, for practical purposes the majority of preclinical studies are conducted in young
Externí odkaz:
https://doaj.org/article/1b4f24a133924f28b0538a31b1ac7be8
Publikováno v:
SLAS Discovery, Vol 27, Iss 2, Pp 95-106 (2022)
The field of Immuno-Oncology (IO) is evolving to utilise novel antibody backbones that can co-target multiple cell-surface stimulatory and inhibitory co-receptors (SICR). This approach necessitates a better understanding of SICR co-expression at the
Externí odkaz:
https://doaj.org/article/9087a34ea27f4b3ea19c5bd2348d173a
Autor:
Ashley Wennerstrom, Catherine G. Haywood, Denise O. Smith, Dakshu Jindal, Carl Rush, Geoffrey W. Wilkinson
Publikováno v:
Frontiers in Public Health, Vol 10 (2023)
IntroductionCommunity health workers (CHWs) have historically worked in community-based settings. Medicaid managed care organizations (MCOs) are integrating CHWs into their teams, largely to support social determinants of health. Little is known abou
Externí odkaz:
https://doaj.org/article/9fbb91eaa7bd48b0a5ed006960605872
Autor:
Marta Lopez-Pelaez, Lucy Young, Mercedes Vazquez-Chantada, Nadine Nelson, Steve Durant, Robert W. Wilkinson, Edmund Poon, Miguel Gaspar, Viia Valge-Archer, Paul Smith, Simon J. Dovedi
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The concept of exploiting tumor intrinsic deficiencies in DNA damage repair mechanisms by inhibiting compensatory DNA repair pathways is well established. For example, ATM-deficient cells show increased sensitivity to the ATR inhibitor ceralasertib.
Externí odkaz:
https://doaj.org/article/9d2d450388024f9abe63eda60fc9f35d
Autor:
Etienne J de Jongh, Sherilee L Harper, Shelby S Yamamoto, Carlee J Wright, Craig W Wilkinson, Soumyaditya Ghosh, Simon J G Otto
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0242393 (2022)
Anthropogenic climate change and increasing antimicrobial resistance (AMR) together threaten the last 50 years of public health gains. Honey bees are a model One Health organism to investigate interactions between climate change and AMR. The objectiv
Externí odkaz:
https://doaj.org/article/c4d1f6486c7b4e998fb300e2940c4fb2
Autor:
Stefanie R. Mullins, John P. Vasilakos, Katharina Deschler, Iwen Grigsby, Pete Gillis, Julius John, Matthew J. Elder, John Swales, Elina Timosenko, Zachary Cooper, Simon J. Dovedi, Andrew J. Leishman, Nadia Luheshi, James Elvecrog, Ashenafi Tilahun, Richard Goodwin, Ronald Herbst, Mark A. Tomai, Robert W. Wilkinson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Background Immune checkpoint blockade (ICB) promotes adaptive immunity and tumor regression in some cancer patients. However, in patients with immunologically “cold” tumors, tumor-resident innate immune cell activation may be required to
Externí odkaz:
https://doaj.org/article/664a845e229648008b22d687ebf6b261
Autor:
Shaobo Dai, John R. Horton, Clayton B. Woodcock, Alex W. Wilkinson, Xing Zhang, Or Gozani, Xiaodong Cheng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
SETD3 is the first known metazoan protein histidine methyltransferase but the molecular basis for its target specificity is unclear. Here, the authors elucidate the structural and molecular determinants for the histidine specificity of SETD3.
Externí odkaz:
https://doaj.org/article/f2129526184a4597af28ea92c757a4b4
Autor:
Nadine Nelson, Marta Lopez-Pelaez, Asis Palazon, Edmund Poon, Maike De La Roche, Simon Barry, Viia Valge-Archer, Robert W. Wilkinson, Simon J. Dovedi, Paul D. Smith
Publikováno v:
OncoImmunology, Vol 8, Iss 8, Pp 1-10 (2019)
In vitro assays that evaluate CD8+ T cell-mediated cytotoxicity are important to aid in the development of novel therapeutic approaches to enhance anti-tumor immune responses. Here, we describe a novel cytotoxicity co-culture assay that circumvents t
Externí odkaz:
https://doaj.org/article/bef43dac3ea74350878e6dc63b21d270