Zobrazeno 1 - 10
of 372
pro vyhledávání: '"A W Segal"'
Autor:
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman Van Vleck, Girish Nadkarni, Lee A. Denson, Harry Ostrer, Adam P. Levine, Elena R. Schiff, Anthony W. Segal, Subra Kugathasan, Peter D. Stenson, David N. Cooper, L. Philip Schumm, Scott Snapper, Mark J. Daly, Talin Haritunians, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Steven R. Brant, Dermot P. B. McGovern, Judy H. Cho, Yuval Itan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Inflammatory bowel disease (IBD) is a group of chronic digestive tract inflammatory conditions whose genetic etiology is still poorly understood. The incidence of IBD is particularly high among Ashkenazi Jews. Here, we identify 8 novel and p
Externí odkaz:
https://doaj.org/article/9b4ce2bc11f1400dba2682d34318447c
Autor:
Manuel A Rivas, Brandon E Avila, Jukka Koskela, Hailiang Huang, Christine Stevens, Matti Pirinen, Talin Haritunians, Benjamin M Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Monkol Lek, Konrad J Karczewski, Jonathan Bloom, Eric V Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Aarno Palotie, Steven R Brant, Richard H Duerr, Mark S Silverberg, John D Rioux, Rinse K Weersma, Andre Franke, Luke Jostins, Carl A Anderson, Jeffrey C Barrett, Daniel G MacArthur, Chaim Jalas, Harry Sokol, Ramnik J Xavier, Ann Pulver, Judy H Cho, Dermot P B McGovern, Mark J Daly
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008190 (2019)
[This corrects the article DOI: 10.1371/journal.pgen.1007329.].
Externí odkaz:
https://doaj.org/article/3ae352ebf0834370b7f64609330444d8
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The phagosome microenvironment maintains enzyme activity and function. Here we compared the phagosomal pH of human neutrophils, monocytes, dendritic cells (DC), and monocyte-derived cells. An unexpected observation was the striking difference in phag
Externí odkaz:
https://doaj.org/article/07d694d74ac24902beca50a34a73a080
Autor:
Manuel A Rivas, Brandon E Avila, Jukka Koskela, Hailiang Huang, Christine Stevens, Matti Pirinen, Talin Haritunians, Benjamin M Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Monkol Lek, Konrad J Karczewski, Jonathan Bloom, Eric V Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Aarno Palotie, Steven R Brant, Richard H Duerr, Mark S Silverberg, John D Rioux, Rinse K Weersma, Andre Franke, Luke Jostins, Carl A Anderson, Jeffrey C Barrett, Daniel G MacArthur, Chaim Jalas, Harry Sokol, Ramnik J Xavier, Ann Pulver, Judy H Cho, Dermot P B McGovern, Mark J Daly
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007329 (2018)
As part of a broader collaborative network of exome sequencing studies, we developed a jointly called data set of 5,685 Ashkenazi Jewish exomes. We make publicly available a resource of site and allele frequencies, which should serve as a reference f
Externí odkaz:
https://doaj.org/article/36415c854cfc4f458bf1a4f15bcfe6f2
Autor:
Thean S. Chew, Nuala R. O'Shea, Gavin W. Sewell, Stefan H. Oehlers, Claire M. Mulvey, Philip S. Crosier, Jasminka Godovac-Zimmermann, Stuart L. Bloom, Andrew M. Smith, Anthony W. Segal
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 8, Pp 817-829 (2015)
Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretio
Externí odkaz:
https://doaj.org/article/76a40966cdef441c9f341dd421b8e284
Autor:
Liam Shaw, Andre L. R. Ribeiro, Adam P. Levine, Nikolas Pontikos, Francois Balloux, Anthony W. Segal, Adam P. Roberts, Andrew M. Smith
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT The human microbiome is affected by multiple factors, including the environment and host genetics. In this study, we analyzed the salivary microbiomes of an extended family of Ashkenazi Jewish individuals living in several cities and investi
Externí odkaz:
https://doaj.org/article/c7f5b16c28f749aca4fdc8637d8c3156
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Externí odkaz:
https://doaj.org/article/0a85d11121364fe08257f2f0672f4383
Autor:
Philippe Behe, Juliet R. Foote, Adam P. Levine, Craig D. Platt, Janet Chou, Fernando Benavides, Raif S. Geha, Anthony W. Segal
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl-) current that appeared to be primarily regulated by cytoplasmic ionic strength. The characteristics of
Externí odkaz:
https://doaj.org/article/972cee5756514318a14e2e5693e21b11
Autor:
Saleh Daher, Matthew Frampton, Elena R. Schiff, Anthony W. Segal, Eran Israeli, Noam Ben-Yosef, Adam P. Levine, Fadi Abu Baker, Rifaat Safadi
Publikováno v:
Gastroenterology Report
Background Family studies support a genetic predisposition to inflammatory bowel diseases (IBD), but known genetic variants only partially explain the disease heritability. Families with multiple affected individuals potentially harbour rare and high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31dd0734ffe78cd1de2bca9085e3378
https://doi.org/10.1093/gastro/goab007
https://doi.org/10.1093/gastro/goab007
Autor:
Anthony W. Segal
Publikováno v:
F1000Research, Vol 5 (2016)
The cause of Crohn’s disease (CD) has posed a conundrum for at least a century. A large body of work coupled with recent technological advances in genome research have at last started to provide some of the answers. Initially this review seeks to e
Externí odkaz:
https://doaj.org/article/8538b0e1404b4a8a9620c9698d48204c