Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

Autor: Dr. Safaa M. Kishk, Dr. Kirsty J. McLean, Dr. Sakshi Sood, Darren Smith, Jack W.D. Evans, Prof. Mohamed A. Helal, Prof. Mohamed S. Gomaa, Prof. Ismail Salama, Prof. Samia M. Mostafa, Dr. Luiz Pedro S. de Carvalho, Colin W. Levy, Prof. Andrew W. Munro, Dr. Claire Simons

Publikováno v: ChemistryOpen, Vol 8, Iss 7, Pp 995-1011 (2019)

Abstract The emergence of untreatable drug‐resistant strains of Mycobacterium tuberculosis is a major public health problem worldwide, and the identification of new efficient treatments is urgently needed. Mycobacterium tuberculosis cytochrome P450

Externí odkaz: https://doaj.org/article/3aae741715394bd2a5f6041ac6a202cf

A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism

Autor: Sian Thistlethwaite, Laura N. Jeffreys, Hazel M. Girvan, Kirsty J. McLean, Andrew W. Munro

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 21, p 11380 (2021)

CYP102A1 (BM3) is a catalytically self-sufficient flavocytochrome fusion protein isolated from Bacillus megaterium, which displays similar metabolic capabilities to many drug-metabolizing human P450 isoforms. BM3′s high catalytic efficiency, ease o

Externí odkaz: https://doaj.org/article/5d9b5c24683a4f389d4469fba5f9a5c4

The Evolution of the Musculoskeletal Trauma Section of the Orthopaedic In-Training Examination

Autor: M. Kareem Shaath, Christopher H. Garrett, Jianna Lin, Frank R. Avilucea, Mark W. Munro, Joshua R. Langford, George J. Haidukewych

Publikováno v: JAAOS: Global Research and Reviews. 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::474b4abb4a8798bfbb5ccf0808e85faa
https://doi.org/10.5435/jaaosglobal-d-22-00184

Resonator Embedded Photonic Crystal Surface Emitting Lasers

Autor: Zijun Bian, Xingyu Zhao, Katherine J. Rae, Aye S. M. Kyaw, Daehyun Kim, Adam F. McKenzie, Ben C. King, Jingzhao Liu, Stephen Thoms, Paul Reynolds, Neil D. Gerrard, James Grant, Jonathan R. Orchard, Calum H. Hill, Connor W. Munro, Pavlo Ivanov, David T. D. Childs, Richard J. E. Taylor, Richard A. Hogg

Publikováno v: 2022 28th International Semiconductor Laser Conference (ISLC).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd2b306ed0490b3100a4e8c836bdb434
https://doi.org/10.23919/islc52947.2022.9943455

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)

Autor: Martyn Frederickson, Irwin R. Selvam, Dimitrios Evangelopoulos, Kirsty J. McLean, Mona M. Katariya, Richard B. Tunnicliffe, Bethany Campbell, Madeline E. Kavanagh, Sitthivut Charoensutthivarakul, Richard T. Blankley, Colin W. Levy, Luiz Pedro S. de Carvalho, David Leys, Andrew W. Munro, Anthony G. Coyne, Chris Abell

Publikováno v: Frederickson, M, Selvam, I R, Evangelopoulos, D, McLean, K J, Katariya, M M, Tunnicliffe, R B, Campbell, B, Kavanagh, M E, Charoensutthivarakul, S, Blankley, R T, Levy, C W, de Carvalho, L P S, Leys, D, Munro, A W, Coyne, A G & Abell, C 2022, ' A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) ', European Journal of Medicinal Chemistry, vol. 230, 114105 . https://doi.org/10.1016/j.ejmech.2022.114105

There is a pressing need for new drugs against tuberculosis (TB) to combat the growing resistance to current antituberculars. Herein a novel strategy is described for hit generation against promising TB targets involving X-ray crystallographic screen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d9c2705833bafc4766f5cadaceb345