Zobrazeno 1 - 8
of 8
pro vyhledávání: '"A W, Machl"'
Autor:
Eddine Saiah, George P. Vlasuk, Seong A. Kang, Stephanie N. Galda, Shomit Sengupta, Jessica J. Howell, Lisa Molz, David John O'neill, Sarah J. Mahoney, Andreas W. Machl, Seung Hahm, Casey J. Lumpkin
Publikováno v:
Cell Chemical Biology. 26:1203-1213.e13
Summary The mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolic processes. Dysregulation of this kinase complex can result in a variety of human diseases. Rapamycin and its analogs target mTORC1 directly; however, chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e4e82f2a630644712668cbd876df78
https://doi.org/10.1016/j.chembiol.2019.05.009
https://doi.org/10.1016/j.chembiol.2019.05.009
Publikováno v:
Cytometry. 29:371-374
Control of successful genetic complementation of cellular defects in heterogenous cell populations requires biochemical selection markers or cell analytical specifiers. With available gene therapy technologies, only a fraction of a cell population is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9760880fcf6be8f1bd896cc8440e79db
https://doi.org/10.1002/(sici)1097-0320(19971201)29:4<371::aid-cyto14>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19971201)29:4<371::aid-cyto14>3.0.co
Publikováno v:
Electrophoresis. 18:2865-2870
Conventional subtraction library techniques or DNA-transfection studies are standard techniques applied for identification and isolation of genes relevant in monogenetic diseases like Fanconi anemia (FA). The differential display technique (DDT) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf3bf576b537b1fa9fab61598ecfbe8
https://doi.org/10.1002/elps.1150181525
https://doi.org/10.1002/elps.1150181525
Gene expression studies using cDNA arrays require robust and sensitive detection methods. Being extremely sensitive, radioactive detection suffers from the influence of signals positioned in each other’s vicinity, the ‘neighbourhood’ effect. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a142b9e01c6c56e34467fb20f9f3eb
https://europepmc.org/articles/PMC137184/
https://europepmc.org/articles/PMC137184/
Publikováno v:
Molecular and cellular probes. 12(1)
The differential display technique (DDT) was used to compare Fanconi anaemia (FA) fibroblasts with those of normal controls in a screen for genes involved in DNA repair, recognizing and handling damage or indicating cell cycle abnormalities as a resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9671bc80ab14a5f2a409e558e5e68655
https://pubmed.ncbi.nlm.nih.gov/9584076
https://pubmed.ncbi.nlm.nih.gov/9584076
Publikováno v:
Gene. 210(2)
We applied the cDNA differential display technique (DDT) in a DNA-repair deficient cell model to isolate genes involved in dysregulation of cell proliferation and development of cancer. The comparative analysis of mRNA expression patterns of human di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09efa654bb4f6977294fbad1b0a8cfc0
https://pubmed.ncbi.nlm.nih.gov/9573387
https://pubmed.ncbi.nlm.nih.gov/9573387
Publikováno v:
Cytometry. 29(4)
Control of successful genetic complementation of cellular defects in heterogenous cell populations requires biochemical selection markers or cell analytical specifiers. With available gene therapy technologies, only a fraction of a cell population is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28d4bf1c2e5da0c9aa2c955be2b47c50
https://pubmed.ncbi.nlm.nih.gov/9415420
https://pubmed.ncbi.nlm.nih.gov/9415420
Publikováno v:
Gene therapy. 4(4)
Retroviral vectors are effective shuttle systems by introducing therapeutically relevant genes stably into the genome of proliferating cells. The majority of vectors applied for research or clinical applications use neomycin for cell selection and id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d70a07775450115f5d603e682227c6
https://pubmed.ncbi.nlm.nih.gov/9176520
https://pubmed.ncbi.nlm.nih.gov/9176520