Zobrazeno 1 - 10
of 408
pro vyhledávání: '"A W, Leach"'
Autor:
Penelope A. Hancock, Ace North, Adrian W. Leach, Peter Winskill, Azra C. Ghani, H. Charles J. Godfray, Austin Burt, John D. Mumford
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Gene drives are a promising means of malaria control with the potential to cause sustained reductions in transmission. In real environments, however, their impacts will depend on local ecological and epidemiological factors. We develop a dat
Externí odkaz:
https://doaj.org/article/f8b71441a75f4d63a9fe59a6ccea67b7
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Material quality plays a critical role in the performance of nanometer-scale plasmonic structures and represents a significant hurdle to large-scale device integration. Progress has been hindered by the challenges of realizing scalable, high
Externí odkaz:
https://doaj.org/article/2125fd9373ed4d83bfa1f91d8b082f91
Autor:
Laurie E. Steffen McLouth, Fengmin Zhao, Taofeek K. Owonikoko, Josephine L. Feliciano, Nisha A. Mohindra, Suzanne E. Dahlberg, James L. Wade III, Gordan Srkalovic, Bradley W. Lash, Joseph W. Leach, Ticiana A. Leal, Charu Aggarwal, David Cella, Suresh S. Ramalingam, Lynne I. Wagner
Publikováno v:
Cancer Medicine, Vol 9, Iss 20, Pp 7511-7523 (2020)
Abstract Objectives The ECOG‐ACRIN Cancer Research Group trial E2511 recently demonstrated a potential benefit for the addition of veliparib to cisplatin‐etoposide (CE) in patients with extensive stage small cell lung cancer (ES‐SCLC) in a phas
Externí odkaz:
https://doaj.org/article/50292329a4084b0f8f95400fae2f2d06
Autor:
P. Daniela Garcia, Robert W. Leach, Gable M. Wadsworth, Krishna Choudhary, Hua Li, Sharon Aviran, Harold D. Kim, Virginia A. Zakian
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Pop1 and 6 are subunits of RNase P and RNase MRP, which process ribosomal and tRNAs. The authors show that when Pop1 and 6 are impaired, the telomerase subunit Est1 binds telomerase RNA at normal levels, but the binding is unstable. As a result, nucl
Externí odkaz:
https://doaj.org/article/60a84cb1852b4201965cf90b77707313
Autor:
Zishuo Ian Hu, Johanna C. Bendell, Andrea Bullock, Noelle K. LoConte, Hassan Hatoum, Paul Ritch, Hugo Hool, Joseph W. Leach, James Sanchez, Davendra P. S. Sohal, John Strickler, Ravindranath Patel, Andrea Wang‐Gillam, Irfan Firdaus, Kenneth H. Yu, Ann M. Kapoun, Eric Holmgren, Lei Zhou, Jakob Dupont, Vincent Picozzi, Vaibhav Sahai, Eileen M. O'Reilly
Publikováno v:
Cancer Medicine, Vol 8, Iss 11, Pp 5148-5157 (2019)
Abstract Purpose Notch signaling dysregulation is implicated in the development of pancreatic adenocarcinoma (PDAC). Tarextumab is a fully human IgG2 antibody that inhibits Notch2/3 receptors. Patients and Methods Aphase 2, randomized, placebo‐cont
Externí odkaz:
https://doaj.org/article/65d331d0de7c4b2799fe21f23c85e265
Autor:
Michael W. Leach, Katherine Hammerman
Publikováno v:
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2 : Safety Assessment Environmental Toxicologic Pathology ISBN: 9780128210475
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c181d8ac96ac8537561dc598359449be
https://doi.org/10.1016/b978-0-12-821047-5.00024-5
https://doi.org/10.1016/b978-0-12-821047-5.00024-5
Autor:
Basel T. Assaf, Adam D. Aulbach, Virunya Bhat, Brad Bolon, William M. Bracken, Alys E. Bradley, Glenn H. Cantor, Kevin B. Donnelly, Elodie Drevon-Gaillot, Stephen K. Durham, Jeffery A. Engelhardt, Daniela Ennulat, James Fikes, John Reginald Foster, Kathleen Funk, Sibylle Gröters, Magali R. Guffroy, Silvia Guionaud, Katherine Hammerman, Carole Harbison, Claudia Harper, Christopher Hurst, Evan B. Janovitz, Kevin Keane, Stephanie Klein, Rebecca Kohnken, Michael W. Leach, Xiantang Li, René Meisner, Keith Nelson, Thomas Nolte, Arun R. Pandiri, Jonathan A. Phillips, Colin G. Rousseaux, Daniel G. Rudmann, Keegan C. Rudmann, Aaron M. Sargeant, JoAnn C.L. Schuh, A. Eric Schultze, Rani S. Sellers, James A. Swenberg, Eric Tien, John L. Vahle, Lyn M. Wancket, Charles E. Wood
Publikováno v:
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2 : Safety Assessment Environmental Toxicologic Pathology ISBN: 9780128210475
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31409643d62572b0c03a3aa33f1f4680
https://doi.org/10.1016/b978-0-12-821047-5.01002-2
https://doi.org/10.1016/b978-0-12-821047-5.01002-2
Autor:
Hsiao-Tzu Chien, Helen Prior, Laura Andrews, Leon van Aerts, Annick Cauvin, David O. Clarke, Kaushik Datta, Maggie Dempster, Noel Dybdal, Wendy Freebern, Lolke de Haan, Danuta Herzyk, Adam Hey, Thomas Kissner, Sven Kronenberg, Michael W. Leach, Donna Lee, Katrin Schutte, Fiona Sewell, Kevin Trouba, Peter Ulrich, Lucinda Weir, Peter van Meer
Publikováno v:
Regulatory Toxicology and Pharmacology, 138
Contains fulltext : 290916.pdf (Publisher’s version ) (Open Access) To support registration of monoclonal antibodies (mAbs) for chronic indications, 6-month toxicity studies have historically been conducted. Experience with mAb development has show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a712af51bb6e1da72593e0cdaedcd2e2
http://hdl.handle.net/2066/290916
http://hdl.handle.net/2066/290916
Publikováno v:
Nature Chemical Biology. 17:1178-1187
Epitranscriptomic RNA modifications can regulate RNA activity; however, there remains a major gap in our understanding of the RNA chemistry present in biological systems. Here we develop RNA-mediated activity-based protein profiling (RNABPP), a chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20cebcc75c88c48392f582c55256311
https://doi.org/10.1038/s41589-021-00874-8
https://doi.org/10.1038/s41589-021-00874-8
Autor:
Stephanie Meredith, Scotti Brackett, Keith M. Diaz, Kathleen G. Freeman, Erin Huggins, Hadia Khan, Mark W. Leach, Mitchell Levitz, Marsha Michie, Janet Onufer, Brian G. Skotko, Leah Smith, A. Nicole White, Tracy Waller, Kara Ayers
Publikováno v:
Disability and Health Journal. 16:101401
While prenatal screening and testing have expanded substantially over the past decade and provide access to more genetic information, expectant parents are more likely to describe the diagnosis experience as negative than positive. In addition, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728c561ab3324c729834eb4d60ab0463
https://doi.org/10.1016/j.dhjo.2022.101401
https://doi.org/10.1016/j.dhjo.2022.101401