Zobrazeno 1 - 10
of 41
pro vyhledávání: '"A W, Dunah"'
Autor:
Ruth Luthi-Carter, Barbara L Apostol, Anthone W Dunah, Molly M DeJohn, Laurie A Farrell, Gillian P Bates, Anne B Young, David G Standaert, Leslie M Thompson, Jang-Ho J Cha
Publikováno v:
Neurobiology of Disease, Vol 14, Iss 3, Pp 624-636 (2003)
We analyzed NMDA receptor subunit mRNAs, proteins, and anchoring proteins in mice transgenic for exon 1 of the HD gene. R6/2 mice had decreased levels of mRNAs encoding ε1 and ε2 NMDA receptor subunits (mouse orthologs of rat NR2A and NR2B subunits
Externí odkaz:
https://doaj.org/article/4e6b60ce52e44b97b00d9332a0e9f1f1
Autor:
Darren P. Baker, Laura Silvian, Edward Lin, Chris Bergeron, Robert M. Arduini, Craig P. Wildes, Catherine Hession, Kevin Guckian, Jean-Christophe Hus, Anthone W. Dunah, Charles C. Banos, Douglas Marcotte
Publikováno v:
Protein Science. 27:672-680
The membrane protein interacting with kinase C1 (PICK1) plays a trafficking role in the internalization of neuron receptors such as the amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor. Reduction of surface AMPA type receptors on neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::212ac2b24f808f8365e37735c02e02cb
https://doi.org/10.1002/pro.3361
https://doi.org/10.1002/pro.3361
Autor:
Anthone W. Dunah, Thierry Bussiere, Kenneth J. Rhodes, Hairuo Peng, Lin Xu, Mahin Arastu, Gnanasambandam Kumaravel, Joy Wang, Melanie S. Brennan, Pamela A. Snodgrass-Belt, Arthur G. Taveras, Mi-young Jung, Tina Talreja, Sowmya Chollate, Zhili Xin, Diana Fahrer, Robert Dunstan, Robert H. Scannevin, Ellen Rohde, H. Moore Arnold
Publikováno v:
Neuropharmacology. 103:57-68
Reducing the production of larger aggregation-prone amyloid β-peptides (Aβ) remains an untested therapeutic approach for reducing the appearance and growth of Aβ plaques in the brain, which are a hallmark pathological feature of Alzheimer's diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c58874b2fa09f0f97a25626acfb40
https://doi.org/10.1016/j.neuropharm.2015.12.006
https://doi.org/10.1016/j.neuropharm.2015.12.006
Autor:
Flora Jow, Istvan J. Enyedy, Darren P. Baker, Catherine Hession, Chris Bergeron, Kenneth J. Rhodes, Robert H. Scannevin, Cassandra F. Borenstein, Gnanasambandam Kumaravel, Edward Yin-Shiang Lin, Timothy R. Chan, Anthone W. Dunah, Richard L. Huganir, Laura Silvian, Jinming Zou, Robert M. Arduini, Fang Qian, Ellen Rohde, Kevin Guckian, Marion Wittmann, Douglas Marcotte, Charles C. Banos
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Protein interacting with C kinase (PICK1) is a scaffolding protein that is present in dendritic spines and interacts with a wide array of proteins through its PDZ domain. The best understood function of PICK1 is regulation of trafficking of AMPA rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809e124eb19a18665035c8a00f6cabaf
http://europepmc.org/articles/PMC6128908
http://europepmc.org/articles/PMC6128908
Autor:
Douglas J, Marcotte, Jean-Christophe, Hus, Charles C, Banos, Craig, Wildes, Robert, Arduini, Chris, Bergeron, Catherine A, Hession, Darren P, Baker, Edward, Lin, Kevin M, Guckian, Anthone W, Dunah, Laura F, Silvian
Publikováno v:
Protein Science : A Publication of the Protein Society
The membrane protein interacting with kinase C1 (PICK1) plays a trafficking role in the internalization of neuron receptors such as the amino‐3‐hydroxyl‐5‐methyl‐4‐isoxazole‐propionate (AMPA) receptor. Reduction of surface AMPA type rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bedd5ddc5302836513b41b7e2443266
https://pubmed.ncbi.nlm.nih.gov/29280296
https://pubmed.ncbi.nlm.nih.gov/29280296
Autor:
Shuko Takeda, Susanne Wegmann, Benjamin D. Moore, Anthone W. Dunah, Rose Pitstick, Chloe K. Nobuhara, Caitlin Commins, Allyson D. Roe, Bradley T. Hyman, Paul H. Weinreb, George A. Carlson, Thierry Bussiere, Sarah L. DeVos, Christoph Hock, Anne Cheung, Jan Grimm, Fabio Montrasio, Marion Wittmann, Matthew P. Frosch, Roger M. Nitsch, Isabel Costantino
The clinical progression of Alzheimer disease (AD) is associated with the accumulation of tau neurofibrillary tangles, which may spread throughout the cortex by interneuronal tau transfer. If so, targeting extracellular tau species may slow the sprea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1219d1f2726721caa936d6e629fe50
https://europepmc.org/articles/PMC5455060/
https://europepmc.org/articles/PMC5455060/
Autor:
Roberto Malinow, Anthone W. Dunah, Charles C. Banos, Richard L. Huganir, Kenneth J. Rhodes, Timothy R. Chan, Helmut W. Kessels, Gnanasambandam Kumaravel, Stephanie Alfonso, Edward Lin, Kevin Guckian, Robert H. Scannevin
Publikováno v:
The European journal of neuroscience, 39(7), 1225-33. Wiley-Blackwell
Amyloid beta (Aβ), a key component in the pathophysiology of Alzheimer's disease, is thought to target excitatory synapses early in the disease. However, the mechanism by which Aβ weakens synapses is not well understood. Here we showed that the PDZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822fd5e041b6d490a3407fc7e3a8bf26
https://hdl.handle.net/20.500.11755/afccf325-bbf2-4f33-a1c8-16e0e0416470
https://hdl.handle.net/20.500.11755/afccf325-bbf2-4f33-a1c8-16e0e0416470
Autor:
Victor Hong, Andres McKenzie, Jianhua Chao, Erin K Harning, Ping Li, Francis Burrows, Jiandong Shi, Rachel Lough, Theodore J. Yun, Marcus F. Boehm, Gerardo Ibanez, Ryan Lamer, Kenneth W Weichert, Christina Boykin, Anthone W. Dunah, Istvan J. Enyedy, Christine Ambrose, Noelito Timple, Ryan Van de Water, Marilyn R. Kehry, Marco A. Biamonte, Joseph Arndt, Jeffrey Thompson, Srinivas Rao Kasibhatla, Cristina M Sandoval, Karen Lundgren, Kevin Hong, Pamela A. Snodgrass-Belt, Sarah A. Bixler
Publikováno v:
Journal of Medicinal Chemistry. 55:7786-7795
Alkyne 40, 5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol (EC144), is a second generation inhibitor of heat shock protein 90 (Hsp90) and is substantially more potent in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fc27a2a6949bbbf83404c803f06d5a
https://doi.org/10.1021/jm300810x
https://doi.org/10.1021/jm300810x
Autor:
Robert H. Scannevin, Tina Talreja, Lin Xu, Gnanasambandam Kumaravel, David Kocisko, Arthur G. Taveras, Anthone W. Dunah, Hairuo Peng, Kenneth J. Rhodes, Ellen Rohde, H. Moore Arnold, Sowmya Chollate, Pamela A. Snodgrass-Belt, Mi-yong Jung, Andrew Zhang, Zhili Xin, Melanie N. Shackett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7277-7280
Starting from literature examples of nonsteroidal anti-inflammatory drugs (NSAIDs)-type carboxylic acid γ-secretase modulators (GSMs) and using a scaffold design approach, we identified 4-aminomethylphenylacetic acid 4 with a desirable γ-secretase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff16ea306e260e39cfe769d34265e32
https://doi.org/10.1016/j.bmcl.2011.10.047
https://doi.org/10.1016/j.bmcl.2011.10.047
Autor:
Tina Talreja, Arthur G. Taveras, Michael Humora, Lawrence Gan, J. Hernan Cuervo, Kenneth J. Rhodes, Hairuo Peng, Lin Xu, Anthone W. Dunah, Gnanasambandam Kumaravel, Pamela A. Snodgrass-Belt, Mi-young Jung, Zhili Xin, Sowmya Chollate, Melanie N. Shackett, Ellen Rohde, H. Moore Arnold, Robert H. Scannevin
Publikováno v:
ACS Medicinal Chemistry Letters. 2:786-791
We have investigated a novel series of acid-derived γ-secretase modulators as a potential treatment of Alzheimer's disease. Optimization based on cellular potency and brain pharmacodynamics after oral dosing led to the discovery of 10a (BIIB042). Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f8cd4a82fc2be0e7dceb3dc620003c
https://doi.org/10.1021/ml200175q
https://doi.org/10.1021/ml200175q