Zobrazeno 1 - 10
of 723
pro vyhledávání: '"A V S Hill"'
Autor:
Eriko Padron-Regalado, Marta Ulaszewska, Alexander D. Douglas, Adrian V. S. Hill, Alexandra J. Spencer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Traditional chemical adjuvants remain a practical means of enhancing the immunogenicity of vaccines. Nevertheless, it is recognized that increasing the immunogenicity of viral vectors is challenging. Recently, STING ligands have been shown t
Externí odkaz:
https://doaj.org/article/f70814aab6204968bd1ba61c5d667587
Autor:
Alexander J. Mentzer, Nicole Brenner, Naomi Allen, Thomas J. Littlejohns, Amanda Y. Chong, Adrian Cortes, Rachael Almond, Michael Hill, Simon Sheard, Gil McVean, UKB Infection Advisory Board, Rory Collins, Adrian V. S. Hill, Tim Waterboer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Here, the authors design a multiplex serology platform to quantitatively measure antibodies against 20 infectious agents in UK Biobank participants and confirm associations of antibody responses with sociodemographic characteristics, HLA genetic vari
Externí odkaz:
https://doaj.org/article/086909a39d6a4b8bbe11b080ee7709f7
Autor:
Kan Li, Michael Dodds, Rachel L. Spreng, Milite Abraha, Richard H. C. Huntwork, Lindsay C. Dahora, Tinashe Nyanhete, Sheetij Dutta, Ulrike Wille-Reece, Erik Jongert, Katie J. Ewer, Adrian V. S. Hill, Celina Jin, Jennifer Hill, Andrew J. Pollard, S. Munir Alam, Georgia D. Tomaras, S. Moses Dennison
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Diversity in specificity of polyclonal antibody (pAb) responses is extensively investigated in vaccine efficacy or immunological evaluations, but the heterogeneity in antibody avidity is rarely probed as convenient tools are lacking. Here we have dev
Externí odkaz:
https://doaj.org/article/daa2eeeb0ae945ebaa3a3cfd1fe010ec
Autor:
Richard Morter, Alfred B. Tiono, Issa Nébié, Oliver Hague, Alphonse Ouedraogo, Amidou Diarra, Nicola K. Viebig, Adrian V. S. Hill, Katie J. Ewer, Sodiomon B. Sirima
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The experimental malaria vaccine ChAd63 MVA ME-TRAP previously showed protective efficacy against Plasmodium falciparum infection in Phase IIa sporozoite challenge studies in adults in the United Kingdom and in a Phase IIb field efficacy trial in Ken
Externí odkaz:
https://doaj.org/article/240454429ddc4eb1b8fa001f9cb31eba
Autor:
Pawan Dulal, Robabeh Gharaei, Adam J. Berg, Adam A. Walters, Nicholas Hawkins, Tim D. W. Claridge, Katarzyna Kowal, Steven Neill, Adam J. Ritchie, Rebecca Ashfield, Adrian V. S. Hill, Giuseppe Tronci, Stephen J. Russell, Alexander D. Douglas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Adenovirus vectors offer a platform technology for vaccine development. The value of the platform has been proven during the COVID-19 pandemic. Although good stability at 2–8 °C is an advantage of the platform, non-cold-chain distribution
Externí odkaz:
https://doaj.org/article/9a17d15607764d48a6123bce56f342f2
Autor:
James J Gilchrist, Kathryn Auckland, Tom Parks, Alexander J Mentzer, Lily Goldblatt, Vivek Naranbhai, Gavin Band, Kirk A Rockett, Ousmane B Toure, Salimata Konate, Sibiri Sissoko, Abdoulaye A Djimdé, Mahamadou A Thera, Ogobara K Doumbo, Samba Sow, Sian Floyd, Jörg M Pönnighaus, David K Warndorff, Amelia C Crampin, Paul E M Fine, Benjamin P Fairfax, Adrian V S Hill
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010312 (2022)
Leprosy is a chronic infection of the skin and peripheral nerves caused by Mycobacterium leprae. Despite recent improvements in disease control, leprosy remains an important cause of infectious disability globally. Large-scale genetic association stu
Externí odkaz:
https://doaj.org/article/1b686b47b5c44125a70cea80ed468575
Autor:
Katharine A. Collins, Florian Brod, Rebecca Snaith, Marta Ulaszewska, Rhea J. Longley, Ahmed M. Salman, Sarah C. Gilbert, Alexandra J. Spencer, David Franco, W. Ripley Ballou, Adrian V. S. Hill
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract An effective vaccine would be a valuable tool for malaria control and elimination; however, the leading malaria vaccine in development, RTS,S/AS01, provided only partial protection in a Phase 3 trial. R21 is a next-generation RTS,S-like vacc
Externí odkaz:
https://doaj.org/article/2049d091dd6f4297bcb5fc1522ae3a45
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Malaria continues to be a pressing global health issue, causing nearly half a million deaths per year. An effective malaria vaccine could radically improve our ability to control and eliminate this pathogen. The most advanced malaria vaccine
Externí odkaz:
https://doaj.org/article/8ced57f921af48a3b8a7e7217fdf7c7d
Autor:
Katja Müller, Matthew P Gibbins, Mark Roberts, Arturo Reyes‐Sandoval, Adrian V S Hill, Simon J Draper, Kai Matuschewski, Olivier Silvie, Julius Clemence R Hafalla
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-15 (2021)
Abstract Immunogenicity is considered one important criterion for progression of candidate vaccines to further clinical evaluation. We tested this assumption in an infection and vaccination model for malaria pre‐erythrocytic stages. We engineered P
Externí odkaz:
https://doaj.org/article/ea7d1952472d4ad6bd50a7cba4c4f6a0
Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency
Autor:
James J. Gilchrist, Sophie Uyoga, Matti Pirinen, Anna Rautanen, Salim Mwarumba, Patricia Njuguna, Neema Mturi, The Kenyan Bacteraemia Study Group, Adrian V. S. Hill, J. Anthony G. Scott, Thomas N. Williams
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-10 (2020)
Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency state in humans. The clinical phenotype is variable and includes asymptomatic individuals, episodic hemolysis induced by oxidative stress, an
Externí odkaz:
https://doaj.org/article/887a5939abb14b14ac4d69169c66abd7