Zobrazeno 1 - 10
of 3 170
pro vyhledávání: '"A V, Turnbull"'
Autor:
Gudrun Schober, Myrtha Arnold, Susan Birtles, Linda K. Buckett, Gustavo Pacheco-López, Andrew V. Turnbull, Wolfgang Langhans, Abdelhak Mansouri
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1369-1384 (2013)
Acyl CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final step in triacylglycerol (TAG) synthesis and is highly expressed in the small intestine. Because DGAT-1 knockout mice are resistant to diet-induced obesity, we investigated the acu
Externí odkaz:
https://doaj.org/article/594a4e189aff489092aac246d741530b
Autor:
Gene P. Ables, Kryscilla Jian Zhang Yang, Silke Vogel, Antonio Hernandez-Ono, Shuiqing Yu, Jason J. Yuen, Susan Birtles, Linda K. Buckett, Andrew V. Turnbull, Ira J. Goldberg, William S. Blaner, Li-Shin Huang, Henry N. Ginsberg
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2364-2379 (2012)
Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 catalyzes the final step of triglyceride (TG) synthesis. We show that acute administration of a DGAT1 inhibitor (DGAT1i) by oral gavage or genetic deletion of intestinal Dgat1 (intestine-Dgat1−/−)
Externí odkaz:
https://doaj.org/article/ef0ae0cad15247f89a3efeb1b1b8818c
Autor:
Li Liu, Shuiqing Yu, Raffay S. Khan, Gene P. Ables, Kalyani G. Bharadwaj, Yunying Hu, Lesley A. Huggins, Jan W. Eriksson, Linda K. Buckett, Andrew V. Turnbull, Henry N. Ginsberg, William S. Blaner, Li-Shin Huang, Ira J. Goldberg
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 732-744 (2011)
Diacylglycerol (DAG) acyl transferase 1 (Dgat1) knockout (−/−) mice are resistant to high-fat-induced obesity and insulin resistance, but the reasons are unclear. Dgat1−/− mice had reduced mRNA levels of all three Ppar genes and genes involve
Externí odkaz:
https://doaj.org/article/28b9b4fb4e8e4a7880d03b89710adc64
Publikováno v:
Mediators of Inflammation, Vol 3, Iss 5, Pp 353-357 (1994)
Modification of endogenous eicosanoid synthesis by dietary n-3 fatty acid supplementation reduces febrile responses, but the mechanisms underlying these effects in vivo have not been determined. In the present study, local inflammation was induced by
Externí odkaz:
https://doaj.org/article/ea702d3a3d804aa79811a101f145657f
Autor:
Peter Gennemark, Daniel Lindén, Andrew V. Turnbull, Anders Johansson, Madeleine Antonsson, Magnus Trägårdh, Björn Carlsson, Karolina Ploj
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 6:458-468
In this study, we present the translational modeling used in the discovery of AZD1979, a melanin-concentrating hormone receptor 1 (MCHr1) antagonist aimed for treatment of obesity. The model quantitatively connects the relevant biomarkers and thereby
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e476bdd4c95365d507448fa69829be9
https://doi.org/10.1002/psp4.12199
https://doi.org/10.1002/psp4.12199
Autor:
Lillevi Kärrberg, Suzanne L. Iverson, Andrew V. Turnbull, Lambertus Benthem, Jenny Börjesson, Björn Carlsson, Marianne Månsson, Madeleine Antonsson, Peter Gennemark, Mikael Bjursell, Daniel Lindén, Liselotte Andersson, Anders Johansson, Karolina Ploj, Dorota Kakol-Palm
Publikováno v:
British Journal of Pharmacology. 173:2739-2751
Background and Purpose Melanin-concentrating hormone (MCH) is an orexigen, and while rodents express one MCH receptor (MCH1 receptor), humans, non-human primates and dogs express two MCH receptors (MCH1 and MCH2). MCH1 receptor antagonists have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1111448ed34e41270c25e4f507ed448a
https://doi.org/10.1111/bph.13548
https://doi.org/10.1111/bph.13548
Publikováno v:
Minnesota Lawyer (Minneapolis, MN). 06/08/2009.
Autor:
Frederick W. Goldberg, Andrew V. Turnbull, Joanne deSchoolmeester, Martin Wild, Graeme R. Robb, Paul D. Kemmitt, James S. Scott, Scott Boyd, John G. Swales, Tove Sjögren, Pablo Morentin Gutierrez, Sam D. Groombridge, Alexander G. Dossetter
Publikováno v:
Journal of Medicinal Chemistry. 57:970-986
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been widely considered by the pharmaceutical industry as a target to treat metabolic syndrome in type II diabetics. We hypothesized that central nervous system (CNS) penetration might be requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3685bf6571883221c3da774cf39012
https://doi.org/10.1021/jm4016729
https://doi.org/10.1021/jm4016729
Autor:
Vinay Sachdev, Christina Leopold, Raimund Bauer, Jay V. Patankar, Jahangir Iqbal, Sasha Obrowsky, Renze Boverhof, Marcela Doktorova, Bernhard Scheicher, Dagmar Kolb, Andrew V. Turnbull, Andreas Zimmer, Gerald Hoefler, Mahmood M. Hussain, Albert K. Groen, Dagmar Kratky
Publikováno v:
ATHEROSCLEROSIS, 275, E10-E11. ELSEVIER IRELAND LTD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386b400b86351c57c91023b6728c7f3f
https://doi.org/10.1016/j.atherosclerosis.2018.06.915
https://doi.org/10.1016/j.atherosclerosis.2018.06.915
Autor:
Andrew V. Turnbull, Joanne deSchoolmeester, Pablo Morentin Gutierrez, Alice Yu, Elizabeth Cottrell, Martin Wild, Anne White, Erika Harno, Mark Denn, Frederick W. Goldberg, John G. Swales, Harriet Andersén, Brendan Leighton, Mohammad Bohlooly-Y
Publikováno v:
Endocrinology
The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a target for novel type 2 diabetes and obesity therapies based on the premise that lowering of tissue glucocorticoids will have positive effects on body weight, glycemic control, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf634861acf23eb4990d21e71a5351e
http://europepmc.org/articles/PMC4192288
http://europepmc.org/articles/PMC4192288