Zobrazeno 1 - 10
of 273
pro vyhledávání: '"A V, Somlyo"'
Publikováno v:
Hypertension. 79
Hypertension (HTN) is highly prevalent and is a significant risk factor for CVD. Excessive vasoconstriction contributes to HTN. Recently, p90 ribosomal S6 kinase, isoform 2 (RSK2) signaling has been shown to play a significant role in the regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf78674e43b812fa3ae6677ac120356
https://doi.org/10.1161/hyp.79.suppl_1.p333
https://doi.org/10.1161/hyp.79.suppl_1.p333
Autor:
Darkhan Utepbergenov, Paulina M Hennig, Urszula Derewenda, Mykhaylo V Artamonov, Avril V Somlyo, Zygmunt S Derewenda
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164343 (2016)
Ribosomal S6 kinases (RSK) play important roles in cell signaling through the mitogen-activated protein kinase (MAPK) pathway. Each of the four RSK isoforms (RSK1-4) is a single polypeptide chain containing two kinase domains connected by a linker se
Externí odkaz:
https://doaj.org/article/d40be82a84454e1082d3881bafeba8be
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134876 (2015)
Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-contracted with KCl or carbachol (CCh), and the pho
Externí odkaz:
https://doaj.org/article/e9ae67a176544eafafdd252da55bb03e
Autor:
Mykhaylo Artamonov, Ko Momotani, Darkhan Utepbergenov, Aaron Franke, Alexander Khromov, Zygmunt S Derewenda, Avril V Somlyo
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58703 (2013)
In the canonical model of smooth muscle (SM) contraction, the contractile force is generated by phosphorylation of the myosin regulatory light chain (RLC20) by the myosin light chain kinase (MLCK). Moreover, phosphorylation of the myosin targeting su
Externí odkaz:
https://doaj.org/article/53ca93556db540b2b84354b9dc296335
The actin associated protein palladin is important for the early smooth muscle cell differentiation.
Autor:
Li Jin, Qiong Gan, Bartosz J Zieba, Silvia M Goicoechea, Gary K Owens, Carol A Otey, Avril V Somlyo
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12823 (2010)
Palladin, an actin associated protein, plays a significant role in regulating cell adhesion and cell motility. Palladin is important for development, as knockdown in mice is embryonic lethal, yet its role in the development of the vasculature is unkn
Externí odkaz:
https://doaj.org/article/e1398857d3cf4bd9a06bec59d3b8fdef
Autor:
Katja T. Koessmeier, Radovan Dvorsky, Mamta Jaiswal, Pontus Aspenström, Urszula Derewenda, Kazem Nouri, Ehsan Amin, Katarina Reis, Mohammad Reza Ahmadian, Avril V. Somlyo
Publikováno v:
Journal of Biological Chemistry. 291:20353-20371
RHO GTPase-activating proteins (RHOGAPs) are one of the major classes of regulators of the RHO-related protein family that are crucial in many cellular processes, motility, contractility, growth, differentiation, and development. Using database searc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::337db1aeac9af0d17f38c5d294da83db
https://doi.org/10.1074/jbc.m116.736967
https://doi.org/10.1074/jbc.m116.736967
Autor:
Swapnil K. Sonkusare, Masumi Eto, Mykhaylo V. Artamonov, Thu H. Le, Urszula Derewenda, Avril V. Somlyo, Zygmunt S. Derewenda, Eric L. Cope, Brant E. Isakson, Ko Momotani, Miranda E. Good
Publikováno v:
Science Signaling. 11
Smooth muscle contraction is triggered when Ca(2+)/calmodulin-dependent myosin light chain kinase (MLCK) phosphorylates the regulatory light chain of myosin (RLC(20)). However, blood vessels from Mlck-deficient mouse embryos retain the ability to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f484af9aba77e94068e69f576ca9c3
https://doi.org/10.1126/scisignal.aar3924
https://doi.org/10.1126/scisignal.aar3924
Autor:
Jiwang Chen, Leigh Anne Swayne, Rachel B. Weaver, Iain A. Greenwood, Mykhaylo V. Artamonov, Miranda E. Good, Alexander S. Keller, Sara A. Murphy, Silvia Penuela, Avril V. Somlyo, Henry R. Askew-Page, Angela K. Best, Ellen L. Mintz, Scott R. Johnstone, Andrew K. J. Boyce, Brant E. Isakson, Roberto F. Machado, Richard D. Minshall, T.C. Stevenson Keller, Leon J. DeLalio
Publikováno v:
Anatomy and Cell Biology Publications
Objective— Sympathetic nerve innervation of vascular smooth muscle cells (VSMCs) is a major regulator of arteriolar vasoconstriction, vascular resistance, and blood pressure. Importantly, α–adrenergic receptor stimulation, which uniquely couples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a0ac8e471e795dcd81ecdfd6d72e51
https://openaccess.sgul.ac.uk/id/eprint/112718/1/nihms979945-1.pdf
https://openaccess.sgul.ac.uk/id/eprint/112718/1/nihms979945-1.pdf
Autor:
Mark W. Majesky, Ko Momotani, Xiu Rong Dong, Li Jin, Mykhaylo V. Artamonov, Avril V. Somlyo, Aaron S. Franke, Ruoya Ho
Publikováno v:
Journal of Biological Chemistry. 290:10353-10367
This study identifies signaling pathways that play key roles in the formation and maintenance of epicardial cells, a source of progenitors for coronary smooth muscle cells (SMCs). After epithelial to mesenchymal transition (EMT), mesenchymal cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497f4ab3fa4991f2fb7b281810d20c06
https://doi.org/10.1074/jbc.m114.613190
https://doi.org/10.1074/jbc.m114.613190
Autor:
Brant E. Isakson, Adam C. Straub, Stephanie M. Mutchler, Mykhaylo V. Artamonov, Thu H. Le, Marie Billaud, Linda Columbus, Joshua T. Butcher, Lisa A. Palmer, Avril V. Somlyo, Anh T. Nguyen, Tyler Johnson, Megan P. Miller, Angela K. Best
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:2594-2600
Objective— Hemoglobin α (Hb α) and endothelial nitric oxide synthase (eNOS) form a macromolecular complex at myoendothelial junctions; the functional role of this interaction remains undefined. To test if coupling of eNOS and Hb α regulates nitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4184432234785e2f4c60025336de7e6
https://doi.org/10.1161/atvbaha.114.303974
https://doi.org/10.1161/atvbaha.114.303974