Zobrazeno 1 - 10
of 26
pro vyhledávání: '"A V, Karpushev"'
Autor:
A. V. Karpushev, M. V. Krasnova, D. Yu. Ivkin, V. B. Mikhailova, E. S. Klimenko, S. V. Okovityi, A. N. Kulikov
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 0 (2023)
Introduction. The development of heart failure is closely associated with the appearance of life threatening arrhythmias, which are often a terminal event for these patients. An analysis of randomized clinical trials of inhibitors of sodium-glucose c
Externí odkaz:
https://doaj.org/article/31504dff9e624ef18f8c1658f9753536
Autor:
Alexey V. Karpushev, Valeria B. Mikhailova, Ekaterina S. Klimenko, Alexander N. Kulikov, Dmitry Yu. Ivkin, Elena Kaschina, Sergey V. Okovityi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9559 (2022)
Empagliflozin, an inhibitor of sodium-glucose co-transporter 2 (iSGLT2), improves cardiovascular outcomes in patients with and without diabetes and possesses an antiarrhythmic activity. However, the mechanisms of these protective effects have not bee
Externí odkaz:
https://doaj.org/article/8841b182946a43768f4eadd8946bcf67
Autor:
L. B. Mitrofanova, D. E. Bobkov, M. G. Oganesyan, A. V. Karpushev, E. G. Koshevaya, А. N. Gorshkov, P. A. Fedotov, M. A. Bortsova, V. K. Grebennik
Publikováno v:
Российский кардиологический журнал, Vol 25, Iss 12 (2020)
Little is known about the electrophysiological characteristics of telocytes found in the working myocardium and sinoatrial node (SAN). Telocyte expres -sion of HCN4 suggests the ability to generate pacemaker potentials. To prove the impulse conductio
Externí odkaz:
https://doaj.org/article/137c2404bc954002a2504ff2e2f67405
Autor:
Tatiana S. Filatova, Denis V. Abramochkin, Alexey V. Karpushev, K. B. Pustovit, Irina Dzhumaniiazova
Publikováno v:
Journal of Physiology and Biochemistry. 77:13-23
Small G-proteins of Rho family modulate the activity of several classes of ion channels, including K+ channels Kv1.2, Kir2.1, and ERG; Ca2+ channels; and epithelial Na+ channels. The present study was aimed to check the RhoA potential regulatory effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b32e1b23a48ccb2c1af0d96de3ab7fd6
https://doi.org/10.1007/s13105-020-00774-w
https://doi.org/10.1007/s13105-020-00774-w
Publikováno v:
Bulletin of Experimental Biology and Medicine. 169:729-733
The effect of small G-proteins of the Rho family on sodium current conducted by cardiac isoform NaV1.5 of voltage-gated sodium channels was studied in heterologous expression system, CHO-K1 cell line transfected with a plasmid containing the NaV1.5 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5fb1ece25ae6930a441e10941b52484
https://doi.org/10.1007/s10517-020-04966-8
https://doi.org/10.1007/s10517-020-04966-8
Autor:
Alexey V. Karpushev, Anna Kostareva, Evgeny N. Mikhaylov, Anastasia K Zaytseva, Dmitry S. Lebedev, Artem Kiselev, Boris S. Zhorov
Publikováno v:
Biochemical and Biophysical Research Communications. 516:777-783
Mutations in gene SCN5A, which encodes cardiac voltage-gated sodium channel Nav1.5, are associated with multiple clinical phenotypes. Here we describe a novel A1294G genetic variant detected in a male patient with combined clinical phenotype includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e608439e01605e7bd18f16b34395a6
https://doi.org/10.1016/j.bbrc.2019.06.080
https://doi.org/10.1016/j.bbrc.2019.06.080
Autor:
Ekaterina S Klimenko, Valeria B Mikhailova, Anna Kostareva, Tatyana Tulintseva, Viola D Vavilova, Elena Vasichkina, Yulia S Yudina, Boris S. Zhorov, Alexey V. Karpushev
Publikováno v:
Cardiology. 147(1)
Background: Brugada syndrome (BrS) is a rare inherited cardiac arrhythmia with increased risk of sudden cardiac death. Mutations in gene SCN5A, which encodes the α-subunit of cardiac voltage-gated sodium channel NaV1.5, have been identified in over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f44aec1d1e276854a63df4d67af2ca
https://pubmed.ncbi.nlm.nih.gov/34628415
https://pubmed.ncbi.nlm.nih.gov/34628415
Autor:
Denis V, Abramochkin, Tatiana S, Filatova, Ksenia B, Pustovit, Irina, Dzhumaniiazova, Alexey V, Karpushev
Publikováno v:
Journal of physiology and biochemistry. 77(1)
Small G-proteins of Rho family modulate the activity of several classes of ion channels, including K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b589ebd668c47e6b504dc3a6e583b7f4
https://pubmed.ncbi.nlm.nih.gov/33145656
https://pubmed.ncbi.nlm.nih.gov/33145656
Publikováno v:
Bulletin of experimental biology and medicine. 169(6)
The effect of small G-proteins of the Rho family on sodium current conducted by cardiac isoform Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e23f4626cd1149602ea88d16a0f36b3d
https://pubmed.ncbi.nlm.nih.gov/33098508
https://pubmed.ncbi.nlm.nih.gov/33098508
Autor:
Alexey V Karpushev, Daria V Ilatovskaya, Tengis S Pavlov, Yuri A Negulyaev, Alexander Staruschenko
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8827 (2010)
BACKGROUND: The Epithelial Na(+) Channel (ENaC) plays a central role in control of epithelial surface hydration and vascular volume. Similar to other ion channels, ENaC activity is regulated, in part, by cortical cytoskeleton. Besides, the cytoskelet
Externí odkaz:
https://doaj.org/article/a53bbc2e64ad42aebabf350ac65dd5a2