Zobrazeno 1 - 10
of 23
pro vyhledávání: '"A V, Goonawardena"'
Autor:
Anushka V. Goonawardena, Stephen R. Morairty, Gabriel A. Orellana, Adrian R. Willoughby, Tanya L. Wallace, Thomas S. Kilduff
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 6, Iss , Pp 9-23 (2019)
Most preclinical sleep studies are conducted in nocturnal rodents that have fragmented sleep in comparison to humans who are primarily diurnal, typically with a consolidated sleep period. Consequently, we sought to define basal sleep characteristics,
Externí odkaz:
https://doaj.org/article/3e56bbdf27944d99ae34da074d16aa8e
Autor:
Andrew B. Tobin, Gerard R. Dawson, Patrick M. Sexton, Nathan Robertson, Sophie J. Bradley, Francesca Perini, Arthur Christopoulos, James C. Errey, Barry John Teobald, John Francis William Deakin, Lisa M. Broad, Jan Liptrot, Christopher J. Langmead, K.A. Bennett, Mary Vinson, Pradeep J. Nathan, Colin Molloy, Robert M. Cooke, Edward Hurrell, Michael Browning, Krzysztof Okrasa, Jason M Brown, Giulio Mattedi, Alastair J. H. Brown, David M. Cross, Greg J. Osborne, Julie E. Cansfield, Ali Jazayeri, Christoffer Bundgaard, Stephen R. Morairty, J.C. Patel, Fiona H. Marshall, Brian D. Hudson, Prakash Rucktooa, Robert T. Smith, Keith G. Phillips, Louis Dwomoh, Chris de Graaf, Malcolm Peter Weir, Julie Warneck, Giles A. Brown, Mark Pickworth, Benjamin G. Tehan, Tim Tasker, Anushka V. Goonawardena, Miles Congreve, João M. Dias, Shahram Shahabi
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b008b7a3c01abe25b8e63fdab465cc4
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
Autor:
Anushka V. Goonawardena, Thomas S. Kilduff, Gabriel A. Orellana, Ryan Dell, Marius C. Hoener, Stephen R. Morairty, Tanya L. Wallace
Publikováno v:
Neuropsychopharmacology
Trace amine-associated receptor 1 (TAAR1) is a G-protein coupled receptor with affinity for the trace amines. TAAR1 agonists have pro-cognitive, antidepressant-, and antipsychotic-like properties in both rodents and non-human primates (NHPs). TAAR1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fe572c0920497845fee13551f9f41f
https://doi.org/10.1038/s41386-019-0386-8
https://doi.org/10.1038/s41386-019-0386-8
Autor:
Alastair J H, Brown, Sophie J, Bradley, Fiona H, Marshall, Giles A, Brown, Kirstie A, Bennett, Jason, Brown, Julie E, Cansfield, David M, Cross, Chris, de Graaf, Brian D, Hudson, Louis, Dwomoh, João M, Dias, James C, Errey, Edward, Hurrell, Jan, Liptrot, Giulio, Mattedi, Colin, Molloy, Pradeep J, Nathan, Krzysztof, Okrasa, Greg, Osborne, Jayesh C, Patel, Mark, Pickworth, Nathan, Robertson, Shahram, Shahabi, Christoffer, Bundgaard, Keith, Phillips, Lisa M, Broad, Anushka V, Goonawardena, Stephen R, Morairty, Michael, Browning, Francesca, Perini, Gerard R, Dawson, John F W, Deakin, Robert T, Smith, Patrick M, Sexton, Julie, Warneck, Mary, Vinson, Tim, Tasker, Benjamin G, Tehan, Barry, Teobald, Arthur, Christopoulos, Christopher J, Langmead, Ali, Jazayeri, Robert M, Cooke, Prakash, Rucktooa, Miles S, Congreve, Malcolm, Weir, Andrew B, Tobin
Publikováno v:
Trends Pharmacol Sci
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7763e10dd2dc92975133618856c2920a
https://pubmed.ncbi.nlm.nih.gov/35101279
https://pubmed.ncbi.nlm.nih.gov/35101279
Autor:
Thomas S. Kilduff, Stephen R. Morairty, Anushka V. Goonawardena, Adrian R. Willoughby, Tanya L. Wallace, Gabriel A. Orellana
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 6, Iss, Pp 9-23 (2019)
Neurobiology of Sleep and Circadian Rhythms
Neurobiology of Sleep and Circadian Rhythms
Most preclinical sleep studies are conducted in nocturnal rodents that have fragmented sleep in comparison to humans who are primarily diurnal, typically with a consolidated sleep period. Consequently, we sought to define basal sleep characteristics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80557ff5407f6fe6eaa0caab2f645152
http://www.sciencedirect.com/science/article/pii/S2451994418300063
http://www.sciencedirect.com/science/article/pii/S2451994418300063
Autor:
Alastair J. H. Brown, Sophie J. Bradley, Giles A. Brown, Kirstie A. Bennett, Jason Brown, Julie E. Cansfield, David M. Cross, João M. Dias, James C. Errey, Edward Hurrell, Jan Liptrot, Colin Molloy, Pradeep J. Nathan, Krzysztof Okrasa, Greg Osbourne, Jayesh C. Patel, Mark Pickworth, Nathan Robertson, Shahram Shahabi, Christoffer Bundgaard, Keith Phillips, Lisa M. Broad, Anushka V. Goonawardena, Stephen R. Morairty, Michael Browning, Francesca Perini, Gerard R. Dawson, John F. W. Deakin, Robert T. Smith, Patrick M. Sexton, Julie Warneck, Mary Vinson, Tim Tasker, Benjamin G. Tehan, Barry Teobald, Arthur Christopoulos, Christopher J. Langmead, Ali Jazayeri, Robert M. Cooke, Fiona H. Marshall, Prakash Rucktooa, Miles S. Congreve, Malcolm Weir, Andrew Tobin
Publikováno v:
SSRN Electronic Journal.
Current therapies for improving memory in Alzheimer’s disease are focused on correcting for defective cholinergic transmission by increasing acetylcholine levels through inhibition of acetylcholinesterase enzymes. These treatments are however assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9223ad5ca22fdc8ece3f25838d310314
https://doi.org/10.2139/ssrn.3641933
https://doi.org/10.2139/ssrn.3641933
Autor:
Kofi-Kermit A Horton, Anushka V. Goonawardena, John Sesay, Allyn C. Howlett, Robert E. Hampson
Chronic and acute agonism as well as acute antagonism of CB(1) receptors reveal modulation of learning and memory during stable performance of a delayed-nonmatch-to-sample (DNMS) memory task. However, it remains unclear how chronic blockade of the CB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562fff7fce7173b2062c380fae2e07ad
https://europepmc.org/articles/PMC6484354/
https://europepmc.org/articles/PMC6484354/
Autor:
Theodore W. Berger, Rosa H. M. Chan, Anushka V. Goonawardena, Robert E. Hampson, Vasilis Z. Marmarelis, Andrew J. Sweatt, Sam A. Deadwyler, Dong Song
Publikováno v:
Behavioural Pharmacology. 22:335-346
It has previously been demonstrated that the detrimental effect on the performance of a delayed nonmatch to sample (DNMS) memory task by exogenously administered cannabinoid (CB1) receptor agonist, WIN 55212-2 (WIN), is reversed by the receptor antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193dd741c354d276457a1840f394a3ae
https://doi.org/10.1097/fbp.0b013e3283473bfd
https://doi.org/10.1097/fbp.0b013e3283473bfd
Publikováno v:
Learning & Memory. 17:502-511
Cannabinoids acting on CB(1) receptors induce learning and memory impairments. However, the identification of novel non-CB(1) receptors which are insensitive to the psychoactive ingredient of marijuana, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58580b1dd8ce3057baa02046854d2416
https://doi.org/10.1101/lm.1893710
https://doi.org/10.1101/lm.1893710
Publikováno v:
Hippocampus. 20:1083-1094
Successful performance by rats of a delayed-nonmatch-to-sample (DNMS) task is hippocampal dependent. We have shown that neurons in hippocampus differentially encode task-relevant events. These responses are critical for correct DNMS performance and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6a5127b30d2092f802e1e493bde63e
https://doi.org/10.1002/hipo.20706
https://doi.org/10.1002/hipo.20706