Balsam fir (Abies balsamea) needles and their essential oil kill overwintering ticks (Ixodes scapularis) at cold temperatures

Autor: Shelley A. Adamo, Amal El Nabbout, Laura V. Ferguson, Jeffrey S. Zbarsky, Nicoletta Faraone

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract The blacklegged tick, Ixodes scapularis, vectors Borrelia burgdorferi, a bacterium that causes Lyme Disease. Although synthetic pesticides can reduce tick numbers, there are concerns about their potential effects on beneficial insects, such

Externí odkaz: https://doaj.org/article/bb3fe0f4cc744d7396c385b307b5b371

Changes in the microbiome and associated host tissue structure in the blue mussel (Mytilus edulis) following exposure to polystyrene microparticles

Autor: Laura V. Ferguson, Ben Hewins, Wesley Harding, Erin MacDonald, Glenys Gibson

Publikováno v: Canadian Journal of Zoology. 100:719-731

Marine life is increasingly exposed to microplastics, which can be ingested and disrupt the relationship between host tissues and their microbiomes. We investigated the effects of microplastics (5 µm polystyrene beads) on the microbial community and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4819dac1bb4bd771c8eb2b5a51e3463
https://doi.org/10.1139/cjz-2021-0104

From perplexing to predictive: are we ready to forecast insect disease susceptibility in a warming world?

Autor: Laura V. Ferguson, Shelley A. Adamo

Publikováno v: Journal of Experimental Biology. 226

Insects are critical to our ecosystems, but we do not fully understand their future in our warming world. Rising temperatures are affecting insect physiology in myriad ways, including changes to their immune systems and the ability to fight infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::756e465db16120447045f18c34e2bb77
https://doi.org/10.1242/jeb.244911

Female ticks (Ixodes scapularis) infected withBorrelia burgdorferihave increased overwintering survival, with implications for tick population growth

Autor: Amal El Nabbout, Laura V. Ferguson, Atsushi Miyashita, Shelley A. Adamo

The tick,Ixodes scapularis, vectors pathogens such asBorrelia burgdorferi, the bacterium that causes Lyme Disease. Over the last few decadesI. scapularishas expanded its range, introducing a novel health threat into these areas. Warming temperatures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35992d46e469793bd81ab055e098f339
https://doi.org/10.1101/2022.12.07.519462

Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer

Autor: R. C. Coombes, P. D. Badman, J. P. Lozano-Kuehne, X. Liu, I. R. Macpherson, I. Zubairi, R. D. Baird, N. Rosenfeld, J. Garcia-Corbacho, N. Cresti, R. Plummer, A. Armstrong, R. Allerton, D. Landers, H. Nicholas, L. McLellan, A. Lim, F. Mouliere, O. E. Pardo, V. Ferguson, M. J. Seckl

Publikováno v: Nature Communications, 13(1):3246. Nature Publishing Group UK
Coombes, R C, Badman, P D, Lozano-Kuehne, J P, Liu, X, Macpherson, I R, Zubairi, I, Baird, R D, Rosenfeld, N, Garcia-Corbacho, J, Cresti, N, Plummer, R, Armstrong, A, Allerton, R, Landers, D, Nicholas, H, McLellan, L, Lim, A, Mouliere, F, Pardo, O E & Seckl, M J 2022, ' Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer ', Nature Communications, vol. 13, no. 1, 3246 . https://doi.org/10.1038/s41467-022-30666-0, https://doi.org/10.1038/s41467-022-30666-0

We conducted a phase IIa, multi-centre, open label, single arm study (RADICAL; NCT01791985) of AZD4547 (a potent and selective inhibitor of Fibroblast Growth Factor Receptor (FGFR)-1, 2 and 3 receptor tyrosine kinases) administered with anastrozole o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf41360879c66a88fb3325689e8e6361