Zobrazeno 1 - 10
of 444
pro vyhledávání: '"A V, BROOKS"'
Autor:
Jesus A Castor-Macias, Jacqueline A Larouche, Emily C Wallace, Bonnie D Spence, Alec Eames, Pamela Duran, Benjamin A Yang, Paula M Fraczek, Carol A Davis, Susan V Brooks, Krishna Rao Maddipati, James F Markworth, Carlos A Aguilar
Publikováno v:
eLife, Vol 12 (2023)
The acute traumatic or surgical loss of skeletal muscle, known as volumetric muscle loss (VML), is a devastating type of injury that results in exacerbated and persistent inflammation followed by fibrosis. The mechanisms that mediate the magnitude an
Externí odkaz:
https://doaj.org/article/31581a1de5ad4f9382524e610ca6c880
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The development and maintenance of neuromuscular junctions (NMJ) are supported by a specialized population of myonuclei that are referred to as the subsynaptic myonuclei (SSM). The relationship between the number of SSM and the integrity of the NMJ a
Externí odkaz:
https://doaj.org/article/b02baecc79984a92a43acbef10d038d1
Akademický článek
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Autor:
Alan J. Russell, Mike DuVall, Ben Barthel, Ying Qian, Angela K. Peter, Breanne L. Newell-Stamper, Kevin Hunt, Sarah Lehman, Molly Madden, Stephen Schlachter, Ben Robertson, Ashleigh Van Deusen, Hector M. Rodriguez, Carlos Vera, Yu Su, Dennis R. Claflin, Susan V. Brooks, Peter Nghiem, Alexis Rutledge, Twlya I. Juehne, Jinsheng Yu, Elisabeth R. Barton, Yangyi E. Luo, Andreas Patsalos, Laszlo Nagy, H. Lee Sweeney, Leslie A. Leinwand, Kevin Koch
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by absence of the protein dystrophin, which acts as a structural link between the basal lamina and contractile machinery to stabilize muscle membranes in response to mechanical stres
Externí odkaz:
https://doaj.org/article/e747694ac75a437988e03985ae826a25
Autor:
Myungjin Kim, Alyson Sujkowski, Sim Namkoong, Bondong Gu, Tyler Cobb, Boyoung Kim, Allison H. Kowalsky, Chun-Seok Cho, Ian Semple, Seung-Hyun Ro, Carol Davis, Susan V. Brooks, Michael Karin, Robert J. Wessells, Jun Hee Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and in
Externí odkaz:
https://doaj.org/article/126b3fa1af5449268749287ab60d04c0
Autor:
Steve D. Guzman, Jennifer Judge, Shahjahan M. Shigdar, Thomas A. Paul, Carol S. Davis, Peter C. Macpherson, James F. Markworth, Holly Van Remmen, Arlan Richardson, Anne McArdle, Susan V. Brooks
Publikováno v:
Frontiers in Aging, Vol 2 (2022)
Aging results in the progressive accumulation of senescent cells in tissues that display loss of proliferative capacity and acquire a senescence-associated secretory phenotype (SASP). The tumor suppressor, p16INK4A, which slows the progression of the
Externí odkaz:
https://doaj.org/article/624eb338e7c1447186d014f1dd94f006
Autor:
Jacqueline A Larouche, Mahir Mohiuddin, Jeongmoon J Choi, Peter J Ulintz, Paula Fraczek, Kaitlyn Sabin, Sethuramasundaram Pitchiaya, Sarah J Kurpiers, Jesus Castor-Macias, Wenxuan Liu, Robert Louis Hastings, Lemuel A Brown, James F Markworth, Kanishka De Silva, Benjamin Levi, Sofia D Merajver, Gregorio Valdez, Joe V Chakkalakal, Young C Jang, Susan V Brooks, Carlos A Aguilar
Publikováno v:
eLife, Vol 10 (2021)
During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume and function impacting mobility and quality of life. Muscle loss is often associated with denervation and a loss of resident muscle stem cells (satellite c
Externí odkaz:
https://doaj.org/article/1102e70e73174fe0b033c99e67010a4a
Autor:
Bumsoo Ahn, Rojina Ranjit, Pavithra Premkumar, Gavin Pharaoh, Katarzyna M. Piekarz, Satoshi Matsuzaki, Dennis R. Claflin, Kaitlyn Riddle, Jennifer Judge, Shylesh Bhaskaran, Kavithalakshmi Satara Natarajan, Erika Barboza, Benjamin Wronowski, Michael Kinter, Kenneth M. Humphries, Timothy M. Griffin, Willard M. Freeman, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 411-428 (2019)
Abstract Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology an
Externí odkaz:
https://doaj.org/article/bf068644f5f343948ea2be767d068283
Autor:
James F. Markworth, Lemuel A. Brown, Eunice Lim, Carolyn Floyd, Jacqueline Larouche, Jesus A. Castor-Macias, Kristoffer B. Sugg, Dylan C. Sarver, Peter C.D. Macpherson, Carol Davis, Carlos A. Aguilar, Krishna Rao Maddipati, Susan V. Brooks
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Specialized proresolving mediators (SPMs) actively limit inflammation and expedite its resolution by modulating leukocyte recruitment and function. Here we profiled intramuscular lipid mediators via liquid chromatography-tandem mass spectrometry–ba
Externí odkaz:
https://doaj.org/article/0c793e0487a74a72877e5b31113c104c
Autor:
Anna Shcherbina, Jacqueline Larouche, Paula Fraczek, Benjamin A. Yang, Lemuel A. Brown, James F. Markworth, Carolina H. Chung, Mehwish Khaliq, Kanishka de Silva, Jeongmoon J. Choi, Mohammad Fallahi-Sichani, Sriram Chandrasekaran, Young C. Jang, Susan V. Brooks, Carlos A. Aguilar
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107964- (2020)
Summary: During aging, there is a progressive loss of volume and function in skeletal muscle that impacts mobility and quality of life. The repair of skeletal muscle is regulated by tissue-resident stem cells called satellite cells (or muscle stem ce
Externí odkaz:
https://doaj.org/article/4c25cc2531574597b3eba84ef930cfd5