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The sequential multiple assignment randomized trial (SMART) is the ideal study design for the evaluation of multistage treatment regimes, which comprise sequential decision rules that recommend treatments for a patient at each of a series of decision
Externí odkaz:
http://arxiv.org/abs/2403.16813
The primary analysis in two-arm clinical trials usually involves inference on a scalar treatment effect parameter; e.g., depending on the outcome, the difference of treatment-specific means, risk difference, risk ratio, or odds ratio. Most clinical t
Externí odkaz:
http://arxiv.org/abs/2204.10739
In many randomized clinical trials of therapeutics for COVID-19, the primary outcome is an ordinal categorical variable, and interest focuses on the odds ratio (active agent vs. control) under the assumption of a proportional odds model. Although at
Externí odkaz:
http://arxiv.org/abs/2106.15559
The COVID-19 pandemic due to the novel coronavirus SARS CoV-2 has inspired remarkable breakthroughs in development of vaccines against the virus and the launch of several phase 3 vaccine trials in Summer 2020 to evaluate vaccine efficacy (VE). Trials
Externí odkaz:
http://arxiv.org/abs/2102.13103
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Akademický článek
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Autor:
Rose, Eric J., Laber, Eric B., Davidian, Marie, Tsiatis, Anastasios A., Zhao, Ying-Qi, Kosorok, Michael R.
Sequential Multiple Assignment Randomized Trials (SMARTs) are considered the gold standard for estimation and evaluation of treatment regimes. SMARTs are typically sized to ensure sufficient power for a simple comparison, e.g., the comparison of two
Externí odkaz:
http://arxiv.org/abs/1906.06646
Autor:
Tsiatis, Anastasios A.1 (AUTHOR), Davidian, Marie1 (AUTHOR) davidian@ncsu.edu, Holloway, Shannon T.1 (AUTHOR)
Publikováno v:
Biometrics. Jun2023, Vol. 79 Issue 2, p975-987. 13p.
Autor:
Cools, Frank *, Johnson, Dana, Camm, Alan J., Bassand, Jean‐Pierre, Verheugt, Freek W.A., Yang, Shu, Tsiatis, Anastasios, Fitzmaurice, David A., Goldhaber, Samuel Z., Kayani, Gloria, Goto, Shinya, Haas, Sylvia, Misselwitz, Frank, Turpie, Alexander G.G., Fox, Keith A.A., Pieper, Karen S., Kakkar, Ajay K.
Publikováno v:
In Journal of Thrombosis and Haemostasis September 2021 19(9):2322-2334
Precision medicine is currently a topic of great interest in clinical and intervention science. One way to formalize precision medicine is through a treatment regime, which is a sequence of decision rules, one per stage of clinical intervention, that
Externí odkaz:
http://arxiv.org/abs/1606.01472